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Stambp STAM binding protein [ Mus musculus (house mouse) ]

Gene ID: 70527, updated on 11-Apr-2024

Summary

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Official Symbol
Stambpprovided by MGI
Official Full Name
STAM binding proteinprovided by MGI
Primary source
MGI:MGI:1917777
See related
Ensembl:ENSMUSG00000006906 AllianceGenome:MGI:1917777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Amsh; mKIAA4198; 5330424L14Rik; 5730422L11Rik
Summary
Predicted to enable Lys63-specific deubiquitinase activity; protein domain specific binding activity; and thiol-dependent deubiquitinase. Acts upstream of or within negative regulation of neuron apoptotic process and protein deubiquitination. Located in cleavage furrow. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human STAMBP (STAM binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 11.5), CNS E18 (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 C3; 6 35.94 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83520188..83552781, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83543206..83575826, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16466 Neighboring gene deoxyguanosine kinase Neighboring gene STARR-positive B cell enhancer ABC_E1066 Neighboring gene actin, gamma 2, smooth muscle, enteric Neighboring gene DENN/MADD domain containing 4C pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3660 Neighboring gene predicted gene, 21284 Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene predicted gene, 57760

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AMSH is required to degrade ubiquitinated proteins in the central nervous system. Suzuki S, et al. Biochem Biophys Res Commun, 2011 May 20. PMID 21531206
  2. Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice. Ishii N, et al. Mol Cell Biol, 2001 Dec. PMID 11713295, Free PMC Article
  3. Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis. Mukai A, et al. J Cell Sci, 2008 Apr 15. PMID 18388320
  4. A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling. Berry DM, et al. Curr Biol, 2002 Aug 6. PMID 12176364
  5. The complexity of antisense transcription revealed by the study of developing male germ cells. Chan WY, et al. Genomics, 2006 Jun. PMID 16458478

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4198

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal-dependent deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of hippocampal neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of hippocampal neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
STAM-binding protein
Names
associated molecule with the SH3 domain of STAM
NP_001349007.1
NP_001349008.1
NP_001349009.1
NP_077201.1
XP_006506646.1
XP_006506647.1
XP_030111450.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362078.1 → NP_001349007.1  STAM-binding protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AB010123, AK136961, CJ073582
    Consensus CDS
    CCDS20280.1
    UniProtKB/Swiss-Prot
    Q3UTI9, Q9CQ26
    UniProtKB/TrEMBL
    Q3TGB1
    Related
    ENSMUSP00000146294.2, ENSMUST00000206592.2
    Conserved Domains (2) summary
    cd08066
    Location:254 → 424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:8 → 114
    USP8_dimer; USP8 dimerization domain

  2. NM_001362079.1 → NP_001349008.1  STAM-binding protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB010123, AK019907, CJ073582
    Consensus CDS
    CCDS20280.1
    UniProtKB/Swiss-Prot
    Q3UTI9, Q9CQ26
    UniProtKB/TrEMBL
    Q3TGB1
    Conserved Domains (2) summary
    cd08066
    Location:254 → 424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:8 → 114
    USP8_dimer; USP8 dimerization domain

  3. NM_001362080.1 → NP_001349009.1  STAM-binding protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC090649
    Consensus CDS
    CCDS20280.1
    UniProtKB/Swiss-Prot
    Q3UTI9, Q9CQ26
    UniProtKB/TrEMBL
    Q3TGB1
    Related
    ENSMUSP00000145871.2, ENSMUST00000206400.2
    Conserved Domains (2) summary
    cd08066
    Location:254 → 424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:8 → 114
    USP8_dimer; USP8 dimerization domain

  4. NM_024239.2 → NP_077201.1  STAM-binding protein

    See identical proteins and their annotated locations for NP_077201.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB010123, AK139391, CJ074803
    Consensus CDS
    CCDS20280.1
    UniProtKB/Swiss-Prot
    Q3UTI9, Q9CQ26
    UniProtKB/TrEMBL
    Q3TGB1
    Related
    ENSMUSP00000070876.8, ENSMUST00000068054.9
    Conserved Domains (2) summary
    cd08066
    Location:254 → 424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:8 → 114
    USP8_dimer; USP8 dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83520188..83552781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255590.2 → XP_030111450.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q3UTI9, Q9CQ26
    UniProtKB/TrEMBL
    Q3TGB1
    Conserved Domains (2) summary
    cd08066
    Location:254 → 424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:8 → 114
    USP8_dimer; USP8 dimerization domain

  2. XM_006506584.4 → XP_006506647.1  STAM-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006506647.1

    UniProtKB/Swiss-Prot
    Q3UTI9, Q9CQ26
    UniProtKB/TrEMBL
    Q3TGB1
    Conserved Domains (2) summary
    cd08066
    Location:254 → 424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:8 → 114
    USP8_dimer; USP8 dimerization domain

  3. XM_006506583.4 → XP_006506646.1  STAM-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006506646.1

    UniProtKB/Swiss-Prot
    Q3UTI9, Q9CQ26
    UniProtKB/TrEMBL
    Q3TGB1
    Conserved Domains (2) summary
    cd08066
    Location:254 → 424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:8 → 114
    USP8_dimer; USP8 dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ26.1 GenPept UniProtKB/Swiss-Prot:Q9CQ26

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