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Lrr1 leucine rich repeat protein 1 [ Mus musculus (house mouse) ]

Gene ID: 69706, updated on 5-Mar-2024

Summary

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Official Symbol
Lrr1provided by MGI
Official Full Name
leucine rich repeat protein 1provided by MGI
Primary source
MGI:MGI:1916956
See related
Ensembl:ENSMUSG00000034883 AllianceGenome:MGI:1916956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LRR-1; Ppil5; 2410005L11Rik
Summary
Orthologous to human LRR1 (leucine rich repeat protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 5.9), liver E14.5 (RPKM 4.9) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C2; 12 28.73 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69215588..69225786)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69168814..69179012)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:70260497-70260606 Neighboring gene ribosomal protein S29 Neighboring gene 7S RNA 1 Neighboring gene STARR-seq mESC enhancer starr_32359 Neighboring gene STARR-positive B cell enhancer ABC_E8485 Neighboring gene STARR-positive B cell enhancer ABC_E5332 Neighboring gene ribosomal protein L36A-like Neighboring gene mannoside acetylglucosaminyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Kamura T, et al. Genes Dev, 2004 Dec 15. PMID 15601820, Free PMC Article
  2. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat protein 1
Names
peptidylprolyl isomerase (cyclophilin) like 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081406.2 → NP_001074875.1  leucine-rich repeat protein 1

    See identical proteins and their annotated locations for NP_001074875.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC099934
    Consensus CDS
    CCDS36462.1
    UniProtKB/Swiss-Prot
    D3YY91
    Related
    ENSMUSP00000106251.2, ENSMUST00000110621.3
    Conserved Domains (3) summary
    cd00116
    Location:184 → 269
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:164 → 186
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:185 → 246
    LRR_8; Leucine rich repeat

RNA

  1. NR_155206.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because it lacks a large part of the coding region found in variant 1.
    Source sequence(s)
    AC099934, AK010419, BG067404
    Related
    ENSMUST00000222520.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69215588..69225786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3YY91.1 GenPept UniProtKB/Swiss-Prot:D3YY91

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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