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Shisa5 shisa family member 5 [ Mus musculus (house mouse) ]

Gene ID: 66940, updated on 5-Mar-2024

Summary

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Official Symbol
Shisa5provided by MGI
Official Full Name
shisa family member 5provided by MGI
Primary source
MGI:MGI:1915044
See related
Ensembl:ENSMUSG00000025647 AllianceGenome:MGI:1915044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Scotin; mShisa5; 2310008D10Rik; 6430628I05Rik
Summary
Predicted to enable WW domain binding activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in endoplasmic reticulum and nuclear envelope. Is expressed in chorion; extraembryonic ectoderm; foregut diverticulum; and yolk sac. Orthologous to human SHISA5 (shisa family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 466.2), mammary gland adult (RPKM 229.2) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F2; 9 59.63 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108867635..108886860)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109038567..109057792)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E192 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Neighboring gene urocortin 2 Neighboring gene STARR-seq mESC enhancer starr_25229 Neighboring gene STARR-positive B cell enhancer ABC_E5105 Neighboring gene STARR-positive B cell enhancer ABC_E5106 Neighboring gene STARR-positive B cell enhancer ABC_E10586 Neighboring gene STARR-positive B cell enhancer ABC_E10587 Neighboring gene STARR-positive B cell enhancer ABC_E5107 Neighboring gene predicted gene, 53191 Neighboring gene three prime repair exonuclease 1 Neighboring gene ATR interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Scotin: A new p63 target gene expressed during epidermal differentiation. Zocchi L, et al. Biochem Biophys Res Commun, 2008 Mar 7. PMID 18164684, Free PMC Article
  2. The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane. Draeby I, et al. Arch Biochem Biophys, 2007 Nov 1. PMID 17889823, Free PMC Article
  3. Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. Bourdon JC, et al. J Cell Biol, 2002 Jul 22. PMID 12135983, Free PMC Article
  4. Cell cycle regulation by the pro-apoptotic gene Scotin. Gupta RK, et al. Cell Cycle, 2008 Aug. PMID 18677103
  5. Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Furushima K, et al. Dev Biol, 2007 Jun 15. PMID 17481602

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse Scotin induces apoptosis and developmental defects when overexpressed in Drosophila.
    Title: Cell cycle regulation by the pro-apoptotic gene Scotin.
  2. We conclude that Scotin is a new p63 target gene induced during epithelial differentiation, a complex process that also involves ER stress induction.
    Title: Scotin: A new p63 target gene expressed during epidermal differentiation.
  3. ALG-2 binding to Scotin is strictly calcium dependent, indicating a role of this interaction in calcium signaling pathways
    Title: The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane.
  4. Scotin plays a role in p53-dependent apoptosis
    Title: Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein shisa-5
Names
shisa homolog 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284332.1 → NP_001271261.1  protein shisa-5 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001271261.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest protein (isoform 3).
    Source sequence(s)
    AC140383, AK212074
    Consensus CDS
    CCDS72309.1
    UniProtKB/Swiss-Prot
    Q9D7I0
    Related
    ENSMUSP00000107690.6, ENSMUST00000112059.10
    Conserved Domains (1) summary
    pfam13908
    Location:26 → 192
    Shisa; Wnt and FGF inhibitory regulator

  2. NM_001357932.1 → NP_001344861.1  protein shisa-5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC140383
    Consensus CDS
    CCDS90665.1
    UniProtKB/TrEMBL
    A0A0G2JGP8, Q8BU09
    Related
    ENSMUSP00000143648.2, ENSMUST00000197099.5
    Conserved Domains (1) summary
    pfam13908
    Location:11 → 123
    Shisa; Wnt and FGF inhibitory regulator

  3. NM_001357933.1 → NP_001344862.1  protein shisa-5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC140383, AK090357
    Consensus CDS
    CCDS90666.1
    UniProtKB/TrEMBL
    Q8BU09
    Related
    ENSMUSP00000142835.2, ENSMUST00000200515.5
    Conserved Domains (1) summary
    pfam13908
    Location:15 → 127
    Shisa; Wnt and FGF inhibitory regulator

  4. NM_001357934.1 → NP_001344863.1  protein shisa-5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC140383
    UniProtKB/TrEMBL
    A0A0G2JER0
    Conserved Domains (1) summary
    pfam13908
    Location:17 → 103
    Shisa; Wnt and FGF inhibitory regulator

  5. NM_001357935.1 → NP_001344864.1  protein shisa-5 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 8-12, encodes isoform 7.
    Source sequence(s)
    AC140383
    Consensus CDS
    CCDS90667.1
    UniProtKB/TrEMBL
    A0A0G2JER0, A0A0G2JGK4
    Related
    ENSMUSP00000142978.2, ENSMUST00000198708.5
    Conserved Domains (1) summary
    pfam13908
    Location:1 → 89
    Shisa; Wnt and FGF inhibitory regulator

  6. NM_001357936.1 → NP_001344865.1  protein shisa-5 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 7 and 9-12, encodes isoform 7.
    Source sequence(s)
    AC140383
    Consensus CDS
    CCDS90667.1
    UniProtKB/TrEMBL
    A0A0G2JER0, A0A0G2JGK4
    Conserved Domains (1) summary
    pfam13908
    Location:1 → 89
    Shisa; Wnt and FGF inhibitory regulator

  7. NM_001357937.1 → NP_001344866.1  protein shisa-5 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 7, 8, and 10-12, encodes isoform 7.
    Source sequence(s)
    AC140383
    Consensus CDS
    CCDS90667.1
    UniProtKB/TrEMBL
    A0A0G2JER0, A0A0G2JGK4
    Conserved Domains (1) summary
    pfam13908
    Location:1 → 89
    Shisa; Wnt and FGF inhibitory regulator

  8. NM_001357939.1 → NP_001344868.1  protein shisa-5 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 7-9, 11, and 12, encodes isoform 7.
    Source sequence(s)
    AC140383
    Consensus CDS
    CCDS90667.1
    UniProtKB/TrEMBL
    A0A0G2JER0, A0A0G2JGK4
    Related
    ENSMUSP00000143613.2, ENSMUST00000197483.5
    Conserved Domains (1) summary
    pfam13908
    Location:1 → 89
    Shisa; Wnt and FGF inhibitory regulator

  9. NM_001357940.1 → NP_001344869.1  protein shisa-5 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 7-10 and 12, encodes isoform 7.
    Source sequence(s)
    AC140383, BF731565
    Consensus CDS
    CCDS90667.1
    UniProtKB/TrEMBL
    A0A0G2JER0, A0A0G2JGK4
    Conserved Domains (1) summary
    pfam13908
    Location:1 → 89
    Shisa; Wnt and FGF inhibitory regulator

  10. NM_001357941.1 → NP_001344870.1  protein shisa-5 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 7-11, encodes isoform 7.
    Source sequence(s)
    AA088083, AC140383
    Consensus CDS
    CCDS90667.1
    UniProtKB/TrEMBL
    A0A0G2JER0, A0A0G2JGK4
    Related
    ENSMUSP00000143599.2, ENSMUST00000196954.5
    Conserved Domains (1) summary
    pfam13908
    Location:1 → 89
    Shisa; Wnt and FGF inhibitory regulator

  11. NM_025858.3 → NP_080134.1  protein shisa-5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_080134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site in the coding region compared to variant 3. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 3.
    Source sequence(s)
    AC140383, AK033545
    Consensus CDS
    CCDS23543.1
    UniProtKB/Swiss-Prot
    Q8BJ86, Q8BJ87, Q8BLE9, Q8K4W3, Q91Z37, Q9CQP5, Q9D7I0
    Related
    ENSMUSP00000026737.8, ENSMUST00000026737.12
    Conserved Domains (1) summary
    pfam13908
    Location:26 → 191
    Shisa; Wnt and FGF inhibitory regulator

  12. NM_026381.5 → NP_080657.1  protein shisa-5 isoform 2

    See identical proteins and their annotated locations for NP_080657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon and initiates translation at an alternate start codon compared to variant 3. The resulting protein (isoform 2) has a distinct N-terminus and is shorter than isoform 3.
    Source sequence(s)
    AC140383, AK081060
    Consensus CDS
    CCDS40771.1
    UniProtKB/TrEMBL
    A0A0G2JER0
    Related
    ENSMUSP00000128901.2, ENSMUST00000154184.5
    Conserved Domains (1) summary
    pfam13908
    Location:2 → 88
    Shisa; Wnt and FGF inhibitory regulator

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108867635..108886860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244508.2 → XP_030100368.1  protein shisa-5 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JER0, A0A0G2JGK4
    Conserved Domains (1) summary
    pfam13908
    Location:1 → 89
    Shisa; Wnt and FGF inhibitory regulator

  2. XM_030244506.1 → XP_030100366.1  protein shisa-5 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JER0, A0A0G2JGK4
    Conserved Domains (1) summary
    pfam13908
    Location:1 → 89
    Shisa; Wnt and FGF inhibitory regulator

  3. XM_006512212.4 → XP_006512275.1  protein shisa-5 isoform X1

    See identical proteins and their annotated locations for XP_006512275.1

    Conserved Domains (1) summary
    pfam13908
    Location:39 → 127
    Shisa; Wnt and FGF inhibitory regulator
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7I0.1 GenPept UniProtKB/Swiss-Prot:Q9D7I0

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