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RMND5B required for meiotic nuclear division 5 homolog B [ Homo sapiens (human) ]

Gene ID: 64777, updated on 3-Apr-2024

Summary

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Official Symbol
RMND5Bprovided by HGNC
Official Full Name
required for meiotic nuclear division 5 homolog Bprovided by HGNC
Primary source
HGNC:HGNC:26181
See related
Ensembl:ENSG00000145916 AllianceGenome:HGNC:26181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GID2; GID2B
Summary
Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 28.7), esophagus (RPKM 18.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
5q35.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (178131014..178150568)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (178681247..178700827)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (177558015..177577569)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16711 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:177541661-177542174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177547789-177548591 Neighboring gene NEDD4 binding protein 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177550999-177551800 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177553540-177554200 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177554863-177555523 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177556537-177557188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177557189-177557840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:177559119-177559648 Neighboring gene Sharpr-MPRA regulatory region 11782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:177577953-177578454 Neighboring gene NHP2 ribonucleoprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:177590971-177591472 Neighboring gene NAD(P)HX epimerase pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:177607056-177607598 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177607599-177608139 Neighboring gene germ cell-less 2, spermatogenesis associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RMND5 from Xenopus laevis is an E3 ubiquitin-ligase and functions in early embryonic forebrain development. Pfirrmann T, et al. PLoS One, 2015. PMID 25793641, Free PMC Article
  2. Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. Pope SN, et al. J Steroid Biochem Mol Biol, 2005 Feb. PMID 15862967
  3. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. van Wijk SJ, et al. Mol Syst Biol, 2009. PMID 19690564, Free PMC Article
  4. Distinct nuclear and cytoplasmic assemblies and interactomes of the mammalian CTLH E3 ligase complex. Onea G, et al. J Cell Sci, 2022 Jul 15. PMID 35833506
  5. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. Lampert F, et al. Elife, 2018 Jun 18. PMID 29911972, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22318, DKFZp434K0926

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein transferase RMND5B
Names
GID complex subunit 2 homolog B
protein RMD5 homolog B
NP_001275723.1
NP_001275724.1
NP_073599.2
XP_005266026.1
XP_005266029.1
XP_016865217.1
XP_047273481.1
XP_047273482.1
XP_054209114.1
XP_054209115.1
XP_054209116.1
XP_054209117.1
XP_054209118.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288794.2 → NP_001275723.1  E3 ubiquitin-protein transferase RMND5B isoform a

    See identical proteins and their annotated locations for NP_001275723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC136632, AK093481, AK125337, CA440193
    Consensus CDS
    CCDS4431.1
    UniProtKB/Swiss-Prot
    Q1HE27, Q6UVY7, Q96G75, Q9H6F6
    UniProtKB/TrEMBL
    B3KSG5
    Related
    ENSP00000420875.1, ENST00000515098.5
    Conserved Domains (2) summary
    COG5109
    Location:60 → 393
    COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam10607
    Location:155 → 299
    CLTH; CTLH/CRA C-terminal to LisH motif domain

  2. NM_001288795.2 → NP_001275724.1  E3 ubiquitin-protein transferase RMND5B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to variant 1.
    Source sequence(s)
    AC136632, AK093481, AK125337, BC009911, CA440193
    Consensus CDS
    CCDS75382.1
    UniProtKB/TrEMBL
    B3KSG5, F5H6G4
    Related
    ENSP00000437630.1, ENST00000542098.2
    Conserved Domains (5) summary
    smart00667
    Location:103 → 135
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:143 → 199
    CTLH; C-terminal to LisH motif
    smart00757
    Location:198 → 291
    CRA; CT11-RanBPM
    pfam10607
    Location:142 → 286
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    pfam13445
    Location:325 → 364
    zf-RING_UBOX; RING-type zinc-finger

  3. NM_022762.5 → NP_073599.2  E3 ubiquitin-protein transferase RMND5B isoform a

    See identical proteins and their annotated locations for NP_073599.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC136632, BC009911, CA440193, DB053605
    Consensus CDS
    CCDS4431.1
    UniProtKB/Swiss-Prot
    Q1HE27, Q6UVY7, Q96G75, Q9H6F6
    UniProtKB/TrEMBL
    B3KSG5
    Related
    ENSP00000320623.4, ENST00000313386.9
    Conserved Domains (2) summary
    COG5109
    Location:60 → 393
    COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam10607
    Location:155 → 299
    CLTH; CTLH/CRA C-terminal to LisH motif domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    178131014..178150568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417525.1 → XP_047273481.1  E3 ubiquitin-protein transferase RMND5B isoform X1

    UniProtKB/Swiss-Prot
    Q1HE27, Q6UVY7, Q96G75, Q9H6F6

  2. XM_017009728.2 → XP_016865217.1  E3 ubiquitin-protein transferase RMND5B isoform X2

    UniProtKB/TrEMBL
    B3KSG5
    Conserved Domains (2) summary
    COG5109
    Location:2 → 333
    COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam10607
    Location:95 → 239
    CLTH; CTLH/CRA C-terminal to LisH motif domain

  3. XM_005265969.5 → XP_005266026.1  E3 ubiquitin-protein transferase RMND5B isoform X1

    See identical proteins and their annotated locations for XP_005266026.1

    UniProtKB/Swiss-Prot
    Q1HE27, Q6UVY7, Q96G75, Q9H6F6
    UniProtKB/TrEMBL
    B3KSG5
    Conserved Domains (2) summary
    COG5109
    Location:60 → 393
    COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam10607
    Location:155 → 299
    CLTH; CTLH/CRA C-terminal to LisH motif domain

  4. XM_047417526.1 → XP_047273482.1  E3 ubiquitin-protein transferase RMND5B isoform X1

    UniProtKB/Swiss-Prot
    Q1HE27, Q6UVY7, Q96G75, Q9H6F6

  5. XM_005265972.4 → XP_005266029.1  E3 ubiquitin-protein transferase RMND5B isoform X2

    See identical proteins and their annotated locations for XP_005266029.1

    UniProtKB/TrEMBL
    B3KSG5
    Conserved Domains (2) summary
    COG5109
    Location:2 → 333
    COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam10607
    Location:95 → 239
    CLTH; CTLH/CRA C-terminal to LisH motif domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    178681247..178700827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353141.1 → XP_054209116.1  E3 ubiquitin-protein transferase RMND5B isoform X1

    UniProtKB/Swiss-Prot
    Q1HE27, Q6UVY7, Q96G75, Q9H6F6

  2. XM_054353139.1 → XP_054209114.1  E3 ubiquitin-protein transferase RMND5B isoform X1

    UniProtKB/Swiss-Prot
    Q1HE27, Q6UVY7, Q96G75, Q9H6F6

  3. XM_054353142.1 → XP_054209117.1  E3 ubiquitin-protein transferase RMND5B isoform X2

  4. XM_054353140.1 → XP_054209115.1  E3 ubiquitin-protein transferase RMND5B isoform X1

    UniProtKB/Swiss-Prot
    Q1HE27, Q6UVY7, Q96G75, Q9H6F6

  5. XM_054353143.1 → XP_054209118.1  E3 ubiquitin-protein transferase RMND5B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96G75.1 GenPept UniProtKB/Swiss-Prot:Q96G75

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