Taok2 TAO kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Taok2provided by RGD
Official Full Name: TAO kinase 2provided by RGD
Primary source: RGD:621590
See related: Ensembl:ENSRNOG00000019964 AllianceGenome:RGD:621590
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tao2
Summary: Enables ATP binding activity and MAP kinase kinase kinase activity. Involved in MAPK cascade; basal dendrite arborization; and regulation of synaptic membrane adhesion. Is active in glutamatergic synapse. Orthologous to human TAOK2 (TAO kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 228.4), Thymus (RPKM 161.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190906236..190925359, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181475708..181494738, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198301789..198354601, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAOK2 directly phosphorylates the cytoskeletal GTPase Septin7, at an evolutionary conserved residue. This phosphorylation induces translocation of Septin7 to the spine, where it associates with and stabilizes the scaffolding protein PSD95, promoting dendritic spine maturation.
Title: TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation.
this analysis of atomic details for TAO2-staurosporine interactions explains the relatively low potency of staurosporine against TAO2
Title: Crystal structure of the MAP3K TAO2 kinase domain bound by an inhibitor staurosporine.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137072 (e-PCR)
- UniSTS:219160

RH144068 (e-PCR)
- UniSTS:233314

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables mitogen-activated protein kinase kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables neuropilin binding	IEA Inferred from Electronic Annotation more info
enables neuropilin binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in basal dendrite arborization	IEA Inferred from Electronic Annotation more info
involved_in basal dendrite arborization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in basal dendrite arborization	ISO Inferred from Sequence Orthology more info
involved_in basal dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basal dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic membrane adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic growth cone	IEA Inferred from Electronic Annotation more info
located_in dendritic growth cone	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase TAO2

Names: serine-threonine kinase; thousand and one amino acid protein 2

NP_073193.1

EC 2.7.11.1

XP_006230391.1

EC 2.7.11.1

XP_006230393.1

EC 2.7.11.1

XP_017445166.1

EC 2.7.11.1

XP_063128858.1

EC 2.7.11.1

XP_063128860.1

EC 2.7.11.1

XP_063128865.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022702.1 → NP_073193.1 serine/threonine-protein kinase TAO2

See identical proteins and their annotated locations for NP_073193.1

Status: PROVISIONAL

Source sequence(s)

AF140556

UniProtKB/Swiss-Prot

A6BM05, Q9JLS3

UniProtKB/TrEMBL

A0A0G2K1M0

Related

ENSRNOP00000071896.2, ENSRNOT00000081291.2

Conserved Domains (2) summary

smart00220
Location:28 → 281

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06634
Location:12 → 319

STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

190906236..190925359 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017589677.3 → XP_017445166.1 serine/threonine-protein kinase TAO2 isoform X3

UniProtKB/TrEMBL

A6I9H7

Conserved Domains (2) summary

COG0419
Location:476 → 915

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06634
Location:12 → 319

STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
XM_063272788.1 → XP_063128858.1 serine/threonine-protein kinase TAO2 isoform X4
XM_006230331.5 → XP_006230393.1 serine/threonine-protein kinase TAO2 isoform X2

UniProtKB/TrEMBL

A6I9H7, F1LSD5

Related

ENSRNOP00000061854.2

Conserved Domains (2) summary

COG0419
Location:482 → 921

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06634
Location:12 → 319

STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
XM_063272790.1 → XP_063128860.1 serine/threonine-protein kinase TAO2 isoform X5
XM_063272795.1 → XP_063128865.1 serine/threonine-protein kinase TAO2 isoform X6
XM_006230329.5 → XP_006230391.1 serine/threonine-protein kinase TAO2 isoform X1

See identical proteins and their annotated locations for XP_006230391.1

UniProtKB/TrEMBL

A0A0G2K1M0, A6I9H9

Conserved Domains (2) summary

smart00220
Location:28 → 281

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06634
Location:12 → 319

STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2