Akap6 A-kinase anchoring protein 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akap6provided by RGD
Official Full Name: A-kinase anchoring protein 6provided by RGD
Primary source: RGD:69412
See related: Ensembl:ENSRNOG00000004841 AllianceGenome:RGD:69412
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: mAkap
Summary: Enables several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of cellular protein metabolic process; regulation of intracellular signal transduction; and regulation of muscle system process. Located in several cellular components, including T-tubule; intercalated disc; and junctional sarcoplasmic reticulum membrane. Part of protein-containing complex. Colocalizes with nuclear envelope. Human ortholog(s) of this gene implicated in anorexia nervosa and ovary epithelial cancer. Orthologous to human AKAP6 (A-kinase anchoring protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 609.6), Brain (RPKM 313.5) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q23

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (75919350..76359667)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (70184101..70624369)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (73553111..73991992)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Signalosome-Regulated Serum Response Factor Phosphorylation Determining Myocyte Growth in Width Versus Length as a Therapeutic Target for Heart Failure.
Title: Signalosome-Regulated Serum Response Factor Phosphorylation Determining Myocyte Growth in Width Versus Length as a Therapeutic Target for Heart Failure.
In cardiac myocytes, PDE4 insulates a mAKAPbeta-targeted PKA pool at the nuclear envelope that prevents nuclear PKA activation upon beta2-AR stimulation.
Title: PDE4 and mAKAPβ are nodal organizers of β2-ARs nuclear PKA signalling in cardiac myocytes.
mAKAPbeta signalosomes serve to bidirectionally regulate the nuclear-cytoplasmic localization of class IIa HDACs.[
Title: Bidirectional regulation of HDAC5 by mAKAPβ signalosomes in cardiac myocytes.
these results highlight the importance of mAKAPbeta signalosomes for regulating MEF2D activity in striated muscle, affirming mAKAPbeta as a nodal regulator in the myocyte intracellular signaling network.
Title: Muscle A-kinase-anchoring protein-β-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D.
These results identify mAKAPalpha as a scaffold for signaling in the stressed neuron that is required for RGC neuroprotection after optic nerve injury.
Title: Muscle A-Kinase Anchoring Protein-α is an Injury-Specific Signaling Scaffold Required for Neurotrophic- and Cyclic Adenosine Monophosphate-Mediated Survival.
This study show genome-wide significant SNP-based associations within three genomic regions 6q16.1 (MIR2113), 14q12 (AKAP6/NPAS3 region) and 19q13.32 (TOMM40/APOE region) with cognition.
Title: Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).
Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes.
Title: Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes.
cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3
Title: cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3.
These results reveal the importance of regulated calcineurin binding to mAKAPbeta for the induction of cardiac myocyte hypertrophy.
Title: The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin.
The association of AC5 with the AKAP6 complex is required for the regulation of cAMP second messenger controlling cardiac myocyte hypertrophy.
Title: An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Got91 (e-PCR)
- UniSTS:113740

D6Wox36 (e-PCR)
- UniSTS:519021

D6Got90 (e-PCR)
- UniSTS:113027

BM384496 (e-PCR)
- UniSTS:261022

AU047448 (e-PCR)
- UniSTS:110499

RH132511 (e-PCR)
- UniSTS:215794

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adenylate cyclase binding	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase A regulatory subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase 2A binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-membrane adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cytokine stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to epinephrine stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth involved in cardiac muscle cell development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase A signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of relaxation of cardiac muscle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
part_of calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in junctional sarcoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
is_active_in sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-kinase anchor protein 6

Names: A kinase (PRKA) anchor protein 6; AKAP-6; PRKA6; protein kinase A-anchoring protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022618.2 → NP_072140.2 A-kinase anchor protein 6

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q9WVC7

UniProtKB/TrEMBL

A6HBI8

Conserved Domains (2) summary

cd00176
Location:960 → 1187

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:783 → 1056

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

75919350..76359667

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594343.3 → XP_017449832.1 A-kinase anchor protein 6 isoform X1

UniProtKB/Swiss-Prot

Q9WVC7

UniProtKB/TrEMBL

G3V6M0

Related

ENSRNOP00000006562.2
XM_039112889.2 → XP_038968817.1 A-kinase anchor protein 6 isoform X3

UniProtKB/TrEMBL

A0A8I6GIZ8

Related

ENSRNOP00000091441.1

Conserved Domains (2) summary

cd00176
Location:961 → 1188

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:783 → 887

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_017594342.3 → XP_017449831.1 A-kinase anchor protein 6 isoform X1

UniProtKB/Swiss-Prot

Q9WVC7

UniProtKB/TrEMBL

G3V6M0
XM_063262448.1 → XP_063118518.1 A-kinase anchor protein 6 isoform X2

UniProtKB/TrEMBL

A6HBI8
XM_063262449.1 → XP_063118519.1 A-kinase anchor protein 6 isoform X2

UniProtKB/TrEMBL

A6HBI8