Cdc20 cell division cycle 20 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdc20provided by RGD
Official Full Name: cell division cycle 20provided by RGD
Primary source: RGD:620477
See related: Ensembl:ENSRNOG00000028415 AllianceGenome:RGD:620477
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p55cdc
Summary: Enables histone deacetylase binding activity. Involved in positive regulation of cell population proliferation and regulation of dendrite development. Located in centrosome and perinuclear region of cytoplasm. Part of protein-containing complex. Orthologous to human CDC20 (cell division cycle 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 195.4), Testes (RPKM 146.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (137251596..137255799, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (131966203..131970406, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (137260728..137264931, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of beta-catenin.
Title: CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of β-catenin.
Up-regulation of cell division cycle 20 expression alters the morphology of neuronal dendritic spines in the nucleus accumbens by promoting FMRP ubiquitination.
Title: Up-regulation of cell division cycle 20 expression alters the morphology of neuronal dendritic spines in the nucleus accumbens by promoting FMRP ubiquitination.
CDK2 blocks APC/CCdc20-mediated ubiquitylation of p21 at the N terminus, causing G2 arrest in mitogen-stimulated cardiomyocytes
Title: Degradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes.
The functional roles of Cdc20 protein is involved in the cell cycle, mitosis, and apoptosis in CBRH-7919 cells.
Title: Functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis.
findings define a Cdc20-APC(anaphase promoting complex) ubiquitin signaling pathway that governs presynaptic development, which holds important implications for neuronal connectivity and plasticity in the brain
Title: A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation.
The expression level and activities of PC-PLC changed in a cell-cycle-dependent manner and were inversely correlated with the expression of Cdc20
Title: Cell-cycle-dependent PC-PLC regulation by APC/C(Cdc20)-mediated ubiquitin-proteasome pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA963388 (e-PCR)
- UniSTS:250634

BF387216 (e-PCR)
- UniSTS:244257

UniSTS:496549 (e-PCR)
- UniSTS:496549

Cdc20 (e-PCR), detects polymorphism
- UniSTS:496549

D5Wox40 (e-PCR)
- UniSTS:518605

BB151133 (e-PCR)
- UniSTS:185598

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables anaphase-promoting complex binding	IEA Inferred from Electronic Annotation more info
enables anaphase-promoting complex binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin ligase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in anaphase-promoting complex-dependent catabolic process	IEA Inferred from Electronic Annotation more info
involved_in anaphase-promoting complex-dependent catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in metaphase/anaphase transition of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in metaphase/anaphase transition of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in metaphase/anaphase transition of meiosis I	IEA Inferred from Electronic Annotation more info
involved_in metaphase/anaphase transition of meiosis I	ISO Inferred from Sequence Orthology more info
involved_in metaphase/anaphase transition of meiosis I	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic metaphase/anaphase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic metaphase/anaphase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse maturation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of meiotic nuclear division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	IEA Inferred from Electronic Annotation more info
part_of anaphase-promoting complex	ISO Inferred from Sequence Orthology more info
part_of anaphase-promoting complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
part_of mitotic checkpoint complex	IEA Inferred from Electronic Annotation more info
part_of mitotic checkpoint complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell division cycle protein 20 homolog

Names: cell cycle protein p55CDC; cell division cycle 20 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_171993.2 → NP_741990.1 cell division cycle protein 20 homolog

See identical proteins and their annotated locations for NP_741990.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O70380, Q5U360, Q62623

UniProtKB/TrEMBL

A0A8L2UL78, A6JZI4

Related

ENSRNOP00000037772.4, ENSRNOT00000036151.5

Conserved Domains (4) summary

COG2319
Location:183 → 473

WD40; WD40 repeat [General function prediction only]

cd00200
Location:190 → 471

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam09751
Location:25 → 99

Es2; Nuclear protein Es2

sd00039
Location:229 → 266

7WD40; WD40 repeat [structural motif]