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Hs1bp3 HCLS1 binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 58240, updated on 5-Mar-2024

Summary

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Official Symbol
Hs1bp3provided by MGI
Official Full Name
HCLS1 binding protein 3provided by MGI
Primary source
MGI:MGI:1913224
See related
Ensembl:ENSMUSG00000020605 AllianceGenome:MGI:1913224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in regulation of apoptotic process. Predicted to act upstream of or within T cell differentiation and cell surface receptor signaling pathway. Predicted to be located in endoplasmic reticulum and mitochondrion. Human ortholog(s) of this gene implicated in essential tremor 2. Orthologous to human HS1BP3 (HCLS1 binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 12.3), subcutaneous fat pad adult (RPKM 11.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A1.1; 12 3.85 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (8363389..8393824)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (8313433..8343824)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31489 Neighboring gene predicted gene, 33037 Neighboring gene STARR-seq mESC enhancer starr_31490 Neighboring gene STARR-seq mESC enhancer starr_31491 Neighboring gene STARR-seq mESC enhancer starr_31492 Neighboring gene STARR-positive B cell enhancer ABC_E8885 Neighboring gene lipid droplet associated hydrolase Neighboring gene STARR-seq mESC enhancer starr_31493 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:8320448-8320557 Neighboring gene STARR-positive B cell enhancer mm9_chr12:8333629-8333930 Neighboring gene growth differentiation factor 7 Neighboring gene STARR-seq mESC enhancer starr_31498 Neighboring gene predicted gene, 48071 Neighboring gene predicted gene, 33134 Neighboring gene STARR-seq mESC enhancer starr_31500 Neighboring gene STARR-seq mESC enhancer starr_31501 Neighboring gene STARR-seq mESC enhancer starr_31502 Neighboring gene predicted gene, 51967

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. Takemoto Y, et al. Int Immunol, 1999 Dec. PMID 10590261
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HCLS1-binding protein 3
Names
HS1 binding protein 3
HSP1BP-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021429.3 → NP_067404.2  HCLS1-binding protein 3

    See identical proteins and their annotated locations for NP_067404.2

    Status: VALIDATED

    Source sequence(s)
    AK040654, AK043263, AK084802, BC095977, BX630393
    Consensus CDS
    CCDS49024.1
    UniProtKB/Swiss-Prot
    E9QLQ4, Q3TC93, Q9Z1K1
    Related
    ENSMUSP00000020927.9, ENSMUST00000020927.10
    Conserved Domains (1) summary
    cd06868
    Location:19 → 138
    PX_HS1BP3; The phosphoinositide binding Phox Homology domain of HS1BP3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    8363389..8393824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157550.1 → XP_036013443.1  HCLS1-binding protein 3 isoform X1

    Conserved Domains (1) summary
    cd06868
    Location:19 → 138
    PX_HS1BP3; The phosphoinositide binding Phox Homology domain of HS1BP3

  2. XM_006515161.4 → XP_006515224.1  HCLS1-binding protein 3 isoform X3

    Conserved Domains (1) summary
    cl02563
    Location:1 → 28
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  3. XM_036157551.1 → XP_036013444.1  HCLS1-binding protein 3 isoform X2

    Conserved Domains (1) summary
    cd06868
    Location:1 → 105
    PX_HS1BP3; The phosphoinositide binding Phox Homology domain of HS1BP3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TC93.2 GenPept UniProtKB/Swiss-Prot:Q3TC93

Gene LinkOut

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