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tradd tnfrsf1a-associated via death domain [ Danio rerio (zebrafish) ]

Gene ID: 58130, updated on 27-Mar-2024

Summary

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Official Symbol
traddprovided by ZNC
Official Full Name
tnfrsf1a-associated via death domainprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000511-5
See related
Ensembl:ENSDARG00000036057 AllianceGenome:ZFIN:ZDB-GENE-000511-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zehn0873; wu:fc59e02; zgc:103556; hm:zehn0873
Summary
Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within positive regulation of apoptotic process. Predicted to be located in cytoplasm; cytoskeleton; and nucleus. Predicted to be part of tumor necrosis factor receptor superfamily complex. Orthologous to human TRADD (TNFRSF1A associated via death domain). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See tradd in Genome Data Viewer
Location:
chromosome: 7
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (29115930..29124578)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (28844780..28853428)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 1 Neighboring gene F-box and leucine-rich repeat protein 8 Neighboring gene guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b Neighboring gene metallothionein-B-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures. Luzio A, et al. Aquat Toxicol, 2016 Aug. PMID 27337697
  2. Localization of genes encoding metallothionein-like protein (mt2 and smtb) in the brain of zebrafish. Teoh SL, et al. J Chem Neuroanat, 2015 Dec. PMID 26571427
  3. The viral TRAF protein (ORF111L) from infectious spleen and kidney necrosis virus interacts with TRADD and induces caspase 8-mediated apoptosis. He BL, et al. PLoS One, 2012. PMID 22615868, Free PMC Article
  4. slc7a6os gene plays a critical role in defined areas of the developing CNS in zebrafish. Benini A, et al. PLoS One, 2015. PMID 25803583, Free PMC Article
  5. Zebrafish fin immune responses during high mortality infections with viral haemorrhagic septicemia rhabdovirus. A proteomic and transcriptomic approach. Encinas P, et al. BMC Genomics, 2010 Sep 27. PMID 20875106, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC103556

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of tumor necrosis factor receptor superfamily complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor type 1-associated DEATH domain protein
Names
TNFR1-associated DEATH domain protein
TNFRSF1A-associated via death domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131607.2 → NP_571682.1  tumor necrosis factor receptor type 1-associated DEATH domain protein

    See identical proteins and their annotated locations for NP_571682.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083425
    UniProtKB/Swiss-Prot
    Q9I9N5
    UniProtKB/TrEMBL
    B2GNQ4
    Related
    ENSDARP00000052344.4, ENSDART00000052345.6
    Conserved Domains (2) summary
    cd08780
    Location:200 → 289
    Death_TRADD; Death Domain of Tumor Necrosis Factor Receptor 1-Associated Death Domain protein
    pfam09034
    Location:59 → 169
    TRADD_N; TRADD, N-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    29115930..29124578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394694.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    507..9155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I9N5.1 GenPept UniProtKB/Swiss-Prot:Q9I9N5

Gene LinkOut

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