IL18 interleukin 18 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Gene symbol: IL18
Gene description: interleukin 18
See related: Ensembl:ENSMMUG00000064111
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	14	NC_041767.1 (105282858..105307586, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	14	NC_027906.1 (105019923..105045542, complement)

Chromosome 14 - NC_041767.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Urine IL-18 measurement, as an early prognostic indicator of survival, may facilitate rapid detection of lethal doses of radiation, based on the currently available data set.
Title: Urine Interleukin-18 (IL-18) as a Biomarker of Total-Body Irradiation: A Preliminary Study in Nonhuman Primates.
SIV infection of rhesus macaques results in the emergence of IL-17-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 expression.
Title: AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection.
The chronically elevated IL-18 levels seen in later stages of HIV infection may contribute significantly to accelerated atherogenesis in this population.
Title: Interleukin-18 predicts atherosclerosis progression in SIV-infected and uninfected rhesus monkeys (Macaca mulatta) on a high-fat/high-cholesterol diet.

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General gene information

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Markers

RH38662 (e-PCR)
- UniSTS:88341

IL18_1978 (e-PCR)
- UniSTS:280780

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-18

Names: interleukin 18 (interferon-gamma-inducing factor); interleukin-18 proprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001032834.2 → NP_001028006.1 interleukin-18

See identical proteins and their annotated locations for NP_001028006.1

Status: PROVISIONAL

Source sequence(s)

AF303732

UniProtKB/TrEMBL

H9EZV8, Q9BGI5

Related

ENSMMUP00000077555.1, ENSMMUT00000094858.1

Conserved Domains (1) summary

cl00094
Location:73 → 185

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041767.1 Reference Mmul_10 Primary Assembly

Range

105282858..105307586 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015115663.2 → XP_014971149.1 interleukin-18 isoform X2

UniProtKB/TrEMBL

A0A5F8AKY2

Conserved Domains (1) summary

cl00094
Location:69 → 181

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_015115661.2 → XP_014971147.1 interleukin-18 isoform X1

UniProtKB/TrEMBL

H9EZV8, Q9BGI5

Conserved Domains (1) summary

cl00094
Location:73 → 185

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_015115662.2 → XP_014971148.1 interleukin-18 isoform X1

UniProtKB/TrEMBL

H9EZV8, Q9BGI5

Conserved Domains (1) summary

cl00094
Location:73 → 185

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).