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phkb phosphorylase kinase, beta [ Danio rerio (zebrafish) ]

Gene ID: 569706, updated on 27-Mar-2024

Summary

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Official Symbol
phkbprovided by ZNC
Official Full Name
phosphorylase kinase, betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110411-149
See related
Ensembl:ENSDARG00000078284 AllianceGenome:ZFIN:ZDB-GENE-110411-149
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-96k10.1
Summary
Predicted to enable calmodulin binding activity. Predicted to be involved in glycogen metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in plasma membrane. Predicted to be part of phosphorylase kinase complex. Human ortholog(s) of this gene implicated in glycogen storage disease IXb. Orthologous to human PHKB (phosphorylase kinase regulatory subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
33
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (42206811..42346045)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (41871445..42010678)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene neuropilin and tolloid like 2 Neighboring gene integrin alpha FG-GAP repeat containing 1 Neighboring gene uncharacterized LOC110439909 Neighboring gene uncharacterized LOC110439939

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Patterns of alternative splicing in response to cold acclimation in fish. Healy TM, et al. J Exp Biol, 2019 Mar 7. PMID 30692167
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of phosphorylase kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphorylase b kinase regulatory subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    42206811..42346045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166402.4 → XP_005166459.1  phosphorylase b kinase regulatory subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDW3, F1Q6F0
    Related
    ENSDARP00000103850.3, ENSDART00000112543.4
    Conserved Domains (1) summary
    pfam00723
    Location:44 → 465
    Glyco_hydro_15; Glycosyl hydrolases family 15

  2. XM_005166403.4 → XP_005166460.1  phosphorylase b kinase regulatory subunit beta isoform X2

    UniProtKB/TrEMBL
    A0A8M2BDU6
    Conserved Domains (1) summary
    pfam00723
    Location:44 → 465
    Glyco_hydro_15; Glycosyl hydrolases family 15

  3. XM_693105.8 → XP_698197.5  phosphorylase b kinase regulatory subunit beta isoform X3

    UniProtKB/TrEMBL
    A0A8N7UTG1, F8W2U7
    Related
    ENSDARP00000124602.2, ENSDART00000148643.4
    Conserved Domains (1) summary
    pfam00723
    Location:41 → 462
    Glyco_hydro_15; Glycosyl hydrolases family 15

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394705.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    207479..281939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021472012.1 → XP_021327687.1  phosphorylase b kinase regulatory subunit beta isoform X4

    UniProtKB/TrEMBL
    A0A8M9P9R7
    Conserved Domains (1) summary
    cl25463
    Location:44 → 465
    Glyco_hydro_15; Glycosyl hydrolases family 15

  2. XM_021472013.1 → XP_021327688.1  phosphorylase b kinase regulatory subunit beta isoform X5

    UniProtKB/TrEMBL
    A0A8M9PKZ8
    Conserved Domains (1) summary
    cl25463
    Location:41 → 462
    Glyco_hydro_15; Glycosyl hydrolases family 15
Nucleotide Protein
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