mylka myosin, light chain kinase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mylkaprovided by ZNC
Official Full Name: myosin, light chain kinase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8207
See related: AllianceGenome:ZFIN:ZDB-GENE-030131-8207
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mylk; mlck1a; smMLCK; zmlck1; fj60a06; wu:fj60a06
Summary: Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and myosin light chain kinase activity. Acts upstream of or within blood coagulation and regulation of cell motility. Predicted to be active in synapse. Is expressed in eye and gut. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; asthma; and thoracic aortic aneurysm. Orthologous to human MYLK (myosin light chain kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (4024250..4145653, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (4055593..4177096, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conclude that Mlck1a is the subtype of MLCK that contributes to platelet shape change and thrombus formation.
Title: Mlck1a is expressed in zebrafish thrombocytes and is an essential component of thrombus formation.

Submit: New GeneRIF Correction

General gene information

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Markers

fj60a06.x1 (e-PCR)
- UniSTS:199645

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables myosin light chain kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle structure development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell motility	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: myosin light chain kinase, smooth muscle

Names: kinase related protein, telokin; myosin light chain kinase 1; smooth muscle MLCK

XP_009302720.1

EC 2.7.11.18

XP_009302721.1

EC 2.7.11.18

XP_017213228.1

EC 2.7.11.18

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

4024250..4145653 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017357739.1 → XP_017213228.1 myosin light chain kinase, smooth muscle isoform X3

UniProtKB/TrEMBL

A0A8M6Z0Z3
XM_009304446.1 → XP_009302721.1 myosin light chain kinase, smooth muscle isoform X2

UniProtKB/TrEMBL

A0A8M3AVR0

Conserved Domains (9) summary

cd00096
Location:678 → 747

Ig; Immunoglobulin domain

cd05762
Location:1199 → 1296

Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)

PHA03255
Location:283 → 461

PHA03255; BDLF3; Provisional

smart00408
Location:1768 → 1835

IGc2; Immunoglobulin C-2 Type

cd00063
Location:1292 → 1381

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1755 → 1845

I-set; Immunoglobulin I-set domain

cd14191
Location:1423 → 1681

STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1

pfam00069
Location:1426 → 1681

Pkinase; Protein kinase domain

cl11960
Location:91 → 165

Ig; Immunoglobulin domain
XM_009304445.1 → XP_009302720.1 myosin light chain kinase, smooth muscle isoform X1

UniProtKB/TrEMBL

A0A8M3BC88

Conserved Domains (9) summary

cd00096
Location:678 → 747

Ig; Immunoglobulin domain

cd05762
Location:1199 → 1296

Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)

PHA03255
Location:283 → 461

PHA03255; BDLF3; Provisional

smart00408
Location:1769 → 1836

IGc2; Immunoglobulin C-2 Type

cd00063
Location:1292 → 1381

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1756 → 1846

I-set; Immunoglobulin I-set domain

cd14191
Location:1423 → 1681

STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1

pfam00069
Location:1426 → 1681

Pkinase; Protein kinase domain

cl11960
Location:91 → 165

Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001105682.1: Suppressed sequence

Description

NM_001105682.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: MYLK (GeneID:396445).