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comtd1 catechol-O-methyltransferase domain containing 1 [ Danio rerio (zebrafish) ]

Gene ID: 568094, updated on 27-Mar-2024

Summary

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Official Symbol
comtd1provided by ZNC
Official Full Name
catechol-O-methyltransferase domain containing 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1072
See related
Ensembl:ENSDARG00000078918 AllianceGenome:ZFIN:ZDB-GENE-030131-1072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb58g04
Summary
Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to act upstream of or within methylation. Is expressed in liver. Orthologous to human COMTD1 (catechol-O-methyltransferase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 13
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (17672527..17685351)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (17541535..17554359)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene leucine rich melanocyte differentiation associated Neighboring gene uncharacterized LOC110440175 Neighboring gene zinc finger protein 503 Neighboring gene uncharacterized LOC103911992 Neighboring gene uncharacterized LOC103911994

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex. Meireles AM, et al. Dev Cell, 2018 Nov 5. PMID 30399334, Free PMC Article
  2. Phylogenetic and developmental analyses indicate complex functions of calcium-activated potassium channels in zebrafish embryonic development. Silic MR, et al. Dev Dyn, 2021 Oct. PMID 33728688, Free PMC Article
  3. Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae. Li ZH, et al. Mol Biosyst, 2011 Jul. PMID 21445457
  4. An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. Mohseny AB, et al. J Pathol, 2012 Jun. PMID 22297719
  5. Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Chestnut B, et al. Dev Dyn, 2020 Feb. PMID 31705559, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
catechol O-methyltransferase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163808.1 → NP_001157280.1  catechol O-methyltransferase domain-containing protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    BX470214, EH510505
    UniProtKB/TrEMBL
    A0A8M1NUZ9
    Related
    ENSDARP00000115880.1, ENSDART00000148269.3
    Conserved Domains (2) summary
    COG4122
    Location:27 → 238
    YrrM; Predicted O-methyltransferase YrrM [General function prediction only]
    cl17173
    Location:40 → 237
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    17672527..17685351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480631.1 → XP_021336306.1  catechol O-methyltransferase domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QJS0
    Conserved Domains (1) summary
    cl17173
    Location:30 → 175
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein Strain
Heading Accession and Version

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