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klhl42 kelch-like family, member 42 [ Danio rerio (zebrafish) ]

Gene ID: 567545, updated on 27-Mar-2024

Summary

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Official Symbol
klhl42provided by ZNC
Official Full Name
kelch-like family, member 42provided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-190
See related
Ensembl:ENSDARG00000006011 AllianceGenome:ZFIN:ZDB-GENE-041210-190
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
klhdc5; si:ch211-234f20.7
Summary
Acts upstream of or within endocrine pancreas development; glucose homeostasis; and pancreas regeneration. Orthologous to human KLHL42 (kelch like family member 42). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (17636058..17642192, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (17647082..17653216, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene CWF19 like cell cycle control factor 1 Neighboring gene WASH complex subunit 3 Neighboring gene DNA-damage regulated autophagy modulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. Tsai HY, et al. BMC Genomics, 2015 Nov 18. PMID 26582102, Free PMC Article
  2. Regulation of spermatogonial development by Fsh: The complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. Safian D, et al. Gen Comp Endocrinol, 2019 Dec 1. PMID 31415728
  3. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pancreas regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
kelch-like protein 42
Names
kelch domain containing 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045136.2 → NP_001038601.2  kelch-like protein 42

    See identical proteins and their annotated locations for NP_001038601.2

    Status: PROVISIONAL

    Source sequence(s)
    BC135056
    UniProtKB/TrEMBL
    A4IGE1
    Related
    ENSDARP00000014696.6, ENSDART00000007030.7
    Conserved Domains (6) summary
    smart00612
    Location:267 → 309
    Kelch; Kelch domain
    PHA03098
    Location:2 → 455
    PHA03098; kelch-like protein; Provisional
    cd14821
    Location:102 → 154
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    sd00038
    Location:209 → 252
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:10 → 94
    BTB; BTB/POZ domain
    pfam01344
    Location:209 → 253
    Kelch_1; Kelch motif

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    17636058..17642192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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