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mepcea methylphosphate capping enzyme a [ Danio rerio (zebrafish) ]

Gene ID: 561384, updated on 11-Apr-2024

Summary

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Official Symbol
mepceaprovided by ZNC
Official Full Name
methylphosphate capping enzyme aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3936
See related
Ensembl:ENSDARG00000059461 AllianceGenome:ZFIN:ZDB-GENE-030131-3936
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mepce; fc59f06; zBCDIN3; wu:fc59f06; si:ch211-283h6.1
Summary
Predicted to enable RNA 5'-methyltransferase activity and snRNA binding activity. Predicted to be involved in RNA modification; positive regulation of protein localization to Cajal body; and positive regulation of snRNA transcription by RNA polymerase II. Predicted to act upstream of or within methylation. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Is expressed in blastoderm cell and brain. Orthologous to human MEPCE (methylphosphate capping enzyme). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 5
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (68766456..68782660, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (67995789..68011974, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene eph receptor B4a Neighboring gene discs large MAGUK scaffold protein 4 Neighboring gene hairy-related 1 Neighboring gene hairy and enhancer of split related-7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Barboric M, et al. Proc Natl Acad Sci U S A, 2009 May 12. PMID 19416841, Free PMC Article
  2. Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Zeng S, et al. Gene, 2002 Jul 10. PMID 12234666
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
7SK snRNA methylphosphate capping enzyme
Names
bcdin3
bicoid-interacting protein 3 homolog
bin3 homolog
bin3, bicoid-interacting 3
NP_001122001.1
XP_021331887.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128529.1 → NP_001122001.1  7SK snRNA methylphosphate capping enzyme

    Status: PROVISIONAL

    Source sequence(s)
    BX537304
    UniProtKB/Swiss-Prot
    A3KQ55
    UniProtKB/TrEMBL
    A0A0A0MPU6, A0A8M1NI31
    Related
    ENSDARP00000121674.1, ENSDART00000141699.2
    Conserved Domains (2) summary
    pfam06859
    Location:588 → 695
    Bin3; Bicoid-interacting protein 3 (Bin3)
    pfam13649
    Location:404 → 455
    Methyltransf_25; Methyltransferase domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    68766456..68782660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476212.1 → XP_021331887.1  7SK snRNA methylphosphate capping enzyme isoform X1

    UniProtKB/Swiss-Prot
    A3KQ55
    UniProtKB/TrEMBL
    A0A0A0MPU6, A0A8M1NI31
    Related
    ENSDARP00000146264.1, ENSDART00000192636.1
    Conserved Domains (2) summary
    pfam06859
    Location:588 → 695
    Bin3; Bicoid-interacting protein 3 (Bin3)
    pfam13649
    Location:404 → 455
    Methyltransf_25; Methyltransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A3KQ55.2 GenPept UniProtKB/Swiss-Prot:A3KQ55

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