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slc1a2a solute carrier family 1 member 2a [ Danio rerio (zebrafish) ]

Gene ID: 560802, updated on 27-Mar-2024

Summary

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Official Symbol
slc1a2aprovided by ZNC
Official Full Name
solute carrier family 1 member 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100422-11
See related
Ensembl:ENSDARG00000052138 AllianceGenome:ZFIN:ZDB-GENE-100422-11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neutral amino acid transmembrane transporter activity. Predicted to be involved in L-aspartate transmembrane transport and L-glutamate import across plasma membrane. Located in cone cell pedicle. Is expressed in brain; photoreceptor cell; and retinal neural layer. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 7
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (49862686..49881742)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (49589947..49608966)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene peptidase domain containing associated with muscle regeneration 1a Neighboring gene four-jointed box kinase 1 Neighboring gene CD44 molecule (IN blood group) a Neighboring gene APAF1 interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Shaping of Signal Transmission at the Photoreceptor Synapse by EAAT2 Glutamate Transporters. Niklaus S, et al. eNeuro, 2017 May-Jun. PMID 28612046, Free PMC Article
  2. Excitatory amino acid transporters in the zebrafish: Letter to "Expression and functional analysis of Na(+)-dependent glutamate transporters from zebrafish brain" from Rico et al. Gesemann M, et al. Brain Res Bull, 2010 Oct 30. PMID 20466040
  3. Phylogenetic analysis of the vertebrate excitatory/neutral amino acid transporter (SLC1/EAAT) family reveals lineage specific subfamilies. Gesemann M, et al. BMC Evol Biol, 2010 Apr 29. PMID 20429920, Free PMC Article
  4. QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis. Breuer M, et al. PLoS One, 2019. PMID 30995231, Free PMC Article
  5. Carbofuran induces increased anxiety-like behaviors in female zebrafish (Danio rerio) through disturbing dopaminergic/norepinephrinergic system. Liu S, et al. Chemosphere, 2020 Aug. PMID 32278909

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-glutamate import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cone cell pedicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
excitatory amino acid transporter 2a; solute carrier family 1 (glial high affinity glutamate transporter), member 2a
Names
EAAT2b
SLC1A2b
excitatory amino acid transporter SLC1A2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190305.1 → NP_001177234.1  excitatory amino acid transporter 2a

    See identical proteins and their annotated locations for NP_001177234.1

    Status: PROVISIONAL

    Source sequence(s)
    HM138692
    UniProtKB/TrEMBL
    A0A0R4IM70, A0A8M2BDY1, D7RVR8
    Related
    ENSDARP00000136807.2, ENSDART00000164165.2
    Conserved Domains (1) summary
    pfam00375
    Location:46 → 476
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    49862686..49881742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477554.1 → XP_021333229.1  solute carrier family 1 (glial high affinity glutamate transporter), member 2a isoform X2

    UniProtKB/TrEMBL
    A0A8M2BDX5
    Conserved Domains (1) summary
    pfam00375
    Location:46 → 476
    SDF; Sodium:dicarboxylate symporter family

  2. XM_005166478.4 → XP_005166535.1  solute carrier family 1 (glial high affinity glutamate transporter), member 2a isoform X2

    UniProtKB/TrEMBL
    A0A8M2BDX5
    Conserved Domains (1) summary
    pfam00375
    Location:46 → 476
    SDF; Sodium:dicarboxylate symporter family

  3. XM_005166477.3 → XP_005166534.1  solute carrier family 1 (glial high affinity glutamate transporter), member 2a isoform X1

    See identical proteins and their annotated locations for XP_005166534.1

    UniProtKB/TrEMBL
    A0A0R4IM70, A0A8M2BDY1, D7RVR8
    Related
    ENSDARP00000143007.1, ENSDART00000174315.2
    Conserved Domains (1) summary
    pfam00375
    Location:46 → 476
    SDF; Sodium:dicarboxylate symporter family
Nucleotide Protein
Heading Accession and Version

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