U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

herc2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 [ Danio rerio (zebrafish) ]

Gene ID: 558479, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
herc2provided by ZNC
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-070718-6
See related
Ensembl:ENSDARG00000073841 AllianceGenome:ZFIN:ZDB-GENE-070718-6
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fd13h10; wu:fd13h10
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and pigmentation disease. Orthologous to human HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 6
Exon count:
93
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (37752752..37848607)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (37774863..37871075)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene NIPA magnesium transporter 2 Neighboring gene NIPA magnesium transporter 1 Neighboring gene oculocutaneous albinism II Neighboring gene oculocutaneous albinism II

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Recent assembly of an imprinted domain from non-imprinted components. Rapkins RW, et al. PLoS Genet, 2006 Oct. PMID 17069464, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase HERC2
Names
hect domain and RLD 2
XP_021327483.1
XP_021327484.1
XP_021332870.1
XP_021332871.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    37752752..37848607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477195.1 → XP_021332870.1  E3 ubiquitin-protein ligase HERC2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QG78
    Conserved Domains (8) summary
    cd08664
    Location:2759 → 2902
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    cd00078
    Location:4418 → 4789
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2700 → 2744
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2453 → 2499
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1204 → 1276
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1862 → 1920
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2548 → 2625
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl27697
    Location:2946 → 3316
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  2. XM_021477196.1 → XP_021332871.1  E3 ubiquitin-protein ligase HERC2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QB68
    Related
    ENSDARP00000098322.3, ENSDART00000110770.4
    Conserved Domains (8) summary
    cd08664
    Location:2759 → 2902
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    cd00078
    Location:4417 → 4788
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2700 → 2744
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2453 → 2499
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1204 → 1276
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1862 → 1920
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2548 → 2625
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl27697
    Location:2946 → 3316
    RCC1; Regulator of chromosome condensation (RCC1) repeat

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394658.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    77..34903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471808.1 → XP_021327483.1  E3 ubiquitin-protein ligase HERC2 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PKG1
    Conserved Domains (3) summary
    cd00078
    Location:1597 → 1968
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl02148
    Location:1 → 81
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl27697
    Location:125 → 495
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  2. XM_021471809.1 → XP_021327484.1  E3 ubiquitin-protein ligase HERC2 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PRI1
    Conserved Domains (3) summary
    cd00078
    Location:1596 → 1967
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl02148
    Location:1 → 81
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl27697
    Location:125 → 495
    RCC1; Regulator of chromosome condensation (RCC1) repeat
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous