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rhobtb4 Rho related BTB domain containing 4 [ Danio rerio (zebrafish) ]

Gene ID: 553415, updated on 27-Mar-2024

Summary

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Official Symbol
rhobtb4provided by ZNC
Official Full Name
Rho related BTB domain containing 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-060315-11
See related
Ensembl:ENSDARG00000016868 AllianceGenome:ZFIN:ZDB-GENE-060315-11
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rhobtb2a
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; engulfment of apoptotic cell; and regulation of cell shape. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (43427891..43509101)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (42827732..42903939)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene uncharacterized LOC101886748 Neighboring gene si:dkey-40c11.2 Neighboring gene rhotekin a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. Fazio M, et al. Elife, 2021 Feb 2. PMID 33527896, Free PMC Article
  2. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457
  3. Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. van der Sar AM, et al. Mol Immunol, 2009 Jul. PMID 19409617
  4. Understanding the complexity of epimorphic regeneration in zebrafish caudal fin tissue: A transcriptomic and proteomic approach. Banu S, et al. Genomics, 2022 Mar. PMID 35134499
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rho related BTB domain containing 4; rho-related BTB domain-containing protein 2
Names
Rho-related BTB domain containing 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099974.2 → NP_001093444.1  Rho related BTB domain containing 4 isoform 2

    See identical proteins and their annotated locations for NP_001093444.1

    Status: VALIDATED

    Source sequence(s)
    BX784028, CR812476
    UniProtKB/TrEMBL
    A0A8M2BCP0, A2BI17
    Related
    ENSDARP00000103939.3, ENSDART00000111587.4
    Conserved Domains (5) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:17 → 208
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:502 → 599
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:492 → 594
    BTB; BTB/POZ domain
    cl02518
    Location:427 → 469
    BTB; BTB/POZ domain

  2. NM_001365558.1 → NP_001352487.1  Rho related BTB domain containing 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX784028, CR812476
    UniProtKB/TrEMBL
    A0A8M2BCL5, F1RD19
    Conserved Domains (3) summary
    cd01873
    Location:26 → 220
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    pfam00651
    Location:505 → 612
    BTB; BTB/POZ domain
    cl28614
    Location:426 → 486
    BTB; Broad-Complex, Tramtrack and Bric a brac

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    43427891..43509101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165313.4 → XP_005165370.1  rho-related BTB domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A2BI17
    Related
    ENSDARP00000144243.1, ENSDART00000177895.2
    Conserved Domains (5) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:17 → 208
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:502 → 599
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:492 → 594
    BTB; BTB/POZ domain
    cl02518
    Location:427 → 469
    BTB; BTB/POZ domain

  2. XM_005165312.4 → XP_005165369.1  rho-related BTB domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    F1RD19
    Related
    ENSDARP00000051113.6, ENSDART00000051114.8
    Conserved Domains (3) summary
    cd01873
    Location:26 → 220
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    pfam00651
    Location:505 → 612
    BTB; BTB/POZ domain
    cl28614
    Location:426 → 486
    BTB; Broad-Complex, Tramtrack and Bric a brac
Nucleotide Protein Strain
Heading Accession and Version

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