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Vmn2r74 vomeronasal 2, receptor 74 [ Mus musculus (house mouse) ]

Gene ID: 546980, updated on 11-Apr-2024

Summary

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Official Symbol
Vmn2r74provided by MGI
Official Full Name
vomeronasal 2, receptor 74provided by MGI
Primary source
MGI:MGI:3643877
See related
Ensembl:ENSMUSG00000090774 AllianceGenome:MGI:3643877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG546980
Summary
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
7 D3; 7 48.43 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (85601075..85610690, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (85951867..85961482, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor 73 Neighboring gene vomeronasal 2, receptor, pseudogene 78 Neighboring gene vomeronasal 2, receptor, pseudogene 79 Neighboring gene vomeronasal 2, receptor, pseudogene 80

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  2. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Young JM, et al. Trends Genet, 2007 May. PMID 17382427
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vomeronasal receptor Vmn2r74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384912.1 → NP_001371841.1  vomeronasal receptor Vmn2r74 precursor

    Status: VALIDATED

    Source sequence(s)
    AC107676, AC156557
    Consensus CDS
    CCDS52296.1
    UniProtKB/TrEMBL
    A0A3B2WBJ5, E9PW21
    Related
    ENSMUSP00000156918.2, ENSMUST00000232886.2
    Conserved Domains (3) summary
    cd15283
    Location:579 → 830
    7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:508 → 559
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:43 → 498
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    85601075..85610690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105187.1: Suppressed sequence

    Description
    NM_001105187.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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