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nectin3b nectin cell adhesion molecule 3b [ Danio rerio (zebrafish) ]

Gene ID: 541491, updated on 27-Mar-2024

Summary

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Official Symbol
nectin3bprovided by ZNC
Official Full Name
nectin cell adhesion molecule 3bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050327-14
See related
Ensembl:ENSDARG00000006604 AllianceGenome:ZFIN:ZDB-GENE-050327-14
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pvrl3b; pvrl3l; fj99c02; nectin3; wu:fj99c02; zgc:113035
Summary
Predicted to enable cell adhesion molecule binding activity and protein homodimerization activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within cell adhesion and spermatid development. Predicted to be located in cell-cell junction and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in adherens junction and apical junction complex. Orthologous to human NECTIN3 (nectin cell adhesion molecule 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 21
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (21450454..21515466, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (21413818..21478830, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) Neighboring gene reticulon 2b Neighboring gene diablo, IAP-binding mitochondrial protein b Neighboring gene odorant receptor, family A, subfamily 113, member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Ferrante MI, et al. Hum Mol Genet, 2009 Jan 15. PMID 18971206, Free PMC Article
  2. Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Martin S, et al. Mol Cell Proteomics, 2010 Dec. PMID 20802085, Free PMC Article
  3. The impact of gene expression regulation on evolution of extracellular signaling pathways. Charoensawan V, et al. Mol Cell Proteomics, 2010 Dec. PMID 20935258, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in apical junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nectin-3-like protein
Names
nectin cell adhesion molecule 3
poliovirus receptor-related 3 like
poliovirus receptor-related 3b
poliovirus receptor-related protein 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014304.1 → NP_001014326.1  nectin-3-like protein precursor

    See identical proteins and their annotated locations for NP_001014326.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091923
    UniProtKB/Swiss-Prot
    A4JYI1, A4JYN6, Q58EG3
    UniProtKB/TrEMBL
    B2GPN6
    Related
    ENSDARP00000121706.1, ENSDART00000147593.3
    Conserved Domains (4) summary
    cd05887
    Location:51 → 148
    Ig1_Nectin-3_like; First immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3) and similar proteins
    cd07704
    Location:151 → 247
    Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
    smart00408
    Location:267 → 327
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:42 → 147
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    21450454..21515466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q58EG3.2 GenPept UniProtKB/Swiss-Prot:Q58EG3

Gene LinkOut

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