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SLIT2 slit guidance ligand 2 [ Bos taurus (cattle) ]

Gene ID: 534164, updated on 5-Mar-2024

Summary

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Official Symbol
SLIT2provided by VGNC
Official Full Name
slit guidance ligand 2provided by VGNC
Primary source
VGNC:VGNC:34960
See related
BGD:BT19603; Ensembl:ENSBTAG00000005108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (39778000..40184422)

Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene protein SET-like Neighboring gene transfer RNA glycine (anticodon ACC) Neighboring gene nucleophosmin-like Neighboring gene microRNA mir-218-1 Neighboring gene parkin coregulated like Neighboring gene potassium voltage-gated channel interacting protein 4 Neighboring gene uncharacterized LOC132345491

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Roundabout binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
slit homolog 2 protein
Names
slit homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191516.2 → NP_001178445.2  slit homolog 2 protein precursor

    See identical proteins and their annotated locations for NP_001178445.2

    Status: VALIDATED

    Source sequence(s)
    NKLS02000006
    UniProtKB/TrEMBL
    F1MLJ7
    Related
    ENSBTAP00000101061.1, ENSBTAT00000133943.1
    Conserved Domains (9) summary
    smart00013
    Location:27 → 58
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:863 → 912
    LRRCT; Leucine rich repeat C-terminal domain
    smart00282
    Location:1187 → 1321
    LamG; Laminin G domain
    cd00054
    Location:1080 → 1116
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00116
    Location:43 → 214
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:38 → 56
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:328 → 368
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:781 → 841
    LRR_8; Leucine rich repeat
    cl15307
    Location:668 → 717
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    39778000..40184422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005207790.5 → XP_005207847.1  slit homolog 2 protein isoform X1

    See identical proteins and their annotated locations for XP_005207847.1

    Related
    ENSBTAP00000053607.4, ENSBTAT00000061059.4
    Conserved Domains (9) summary
    smart00013
    Location:27 → 58
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:859 → 908
    LRRCT; Leucine rich repeat C-terminal domain
    smart00282
    Location:1183 → 1317
    LamG; Laminin G domain
    cd00054
    Location:1076 → 1112
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00116
    Location:43 → 214
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:38 → 56
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:324 → 364
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:777 → 837
    LRR_8; Leucine rich repeat
    cl15307
    Location:664 → 713
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  2. XM_005207792.5 → XP_005207849.1  slit homolog 2 protein isoform X2

    See identical proteins and their annotated locations for XP_005207849.1

    Conserved Domains (10) summary
    smart00013
    Location:27 → 58
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:851 → 900
    LRRCT; Leucine rich repeat C-terminal domain
    smart00282
    Location:1175 → 1309
    LamG; Laminin G domain
    cd00054
    Location:1068 → 1104
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00116
    Location:43 → 214
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:843 → 855
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:38 → 56
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:324 → 364
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:769 → 829
    LRR_8; Leucine rich repeat
    cl15307
    Location:656 → 705
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
Nucleotide Protein Strain
Heading Accession and Version

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