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IDE insulin degrading enzyme [ Bos taurus (cattle) ]

Gene ID: 523752, updated on 5-Mar-2024

Summary

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Official Symbol
IDEprovided by VGNC
Official Full Name
insulin degrading enzymeprovided by VGNC
Primary source
VGNC:VGNC:30033
See related
BGD:BT15108; Ensembl:ENSBTAG00000019759
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See IDE in Genome Data Viewer
Location:
chromosome: 26
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (13881658..13976240, complement)

Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 5 Neighboring gene uncharacterized LOC132343928 Neighboring gene kinesin family member 11 Neighboring gene small ribosomal subunit protein eS12-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptide catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-degrading enzyme
Names
insulin protease
insulinase
insulysin
NP_001069317.1
XP_010818077.1
XP_015316085.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075849.1 → NP_001069317.1  insulin-degrading enzyme

    See identical proteins and their annotated locations for NP_001069317.1

    Status: PROVISIONAL

    Source sequence(s)
    BC114105
    UniProtKB/Swiss-Prot
    Q24K02
    Related
    ENSBTAP00000083212.1, ENSBTAT00000112218.1
    Conserved Domains (1) summary
    COG1025
    Location:54 → 958
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    13881658..13976240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010819775.4 → XP_010818077.1  insulin-degrading enzyme isoform X1

    Related
    ENSBTAP00000102566.1, ENSBTAT00000100692.1
    Conserved Domains (1) summary
    COG1025
    Location:54 → 958
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

  2. XM_015460599.3 → XP_015316085.1  insulin-degrading enzyme isoform X2

    Conserved Domains (1) summary
    COG1025
    Location:13 → 917
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24K02.1 GenPept UniProtKB/Swiss-Prot:Q24K02

Gene LinkOut

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