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ADAM8 ADAM metallopeptidase domain 8 [ Bos taurus (cattle) ]

Gene ID: 519652, updated on 5-Mar-2024

Summary

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Official Symbol
ADAM8provided by VGNC
Official Full Name
ADAM metallopeptidase domain 8provided by VGNC
Primary source
VGNC:VGNC:25612
See related
BGD:BT17409
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 26
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (25732361..25745425)

Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene sortilin related VPS10 domain containing receptor 3 Neighboring gene sperm flagellar protein 1 Neighboring gene tubulin gamma complex associated protein 2 Neighboring gene zinc finger protein 511 Neighboring gene microRNA mir-202

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cellular extravasation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 8
XP_005225761.2
XP_005225762.2
XP_005225763.2
XP_005225764.2
XP_005225765.2
XP_005225767.2
XP_015316211.2
XP_059738017.1
XP_059738018.1
XP_059738019.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    25732361..25745425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059882034.1 → XP_059738017.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X3

  2. XM_015460725.3 → XP_015316211.2  disintegrin and metalloproteinase domain-containing protein 8 isoform X8

    Conserved Domains (5) summary
    smart00050
    Location:414 → 488
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:491 → 608
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:197 → 397
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:53 → 155
    Pep_M12B_propep; Reprolysin family propeptide
    cl27975
    Location:626 → 710
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

  3. XM_005225704.5 → XP_005225761.2  disintegrin and metalloproteinase domain-containing protein 8 isoform X1

    Conserved Domains (6) summary
    smart00050
    Location:414 → 488
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:491 → 608
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:616 → 645
    EGF_2; EGF-like domain
    pfam01421
    Location:197 → 397
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:53 → 155
    Pep_M12B_propep; Reprolysin family propeptide
    cl26464
    Location:641 → 852
    Atrophin-1; Atrophin-1 family

  4. XM_005225705.5 → XP_005225762.2  disintegrin and metalloproteinase domain-containing protein 8 isoform X2

    Conserved Domains (6) summary
    smart00050
    Location:414 → 488
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:491 → 608
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:616 → 645
    EGF_2; EGF-like domain
    pfam01421
    Location:197 → 397
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:53 → 155
    Pep_M12B_propep; Reprolysin family propeptide
    cl26464
    Location:638 → 844
    Atrophin-1; Atrophin-1 family

  5. XM_005225708.5 → XP_005225765.2  disintegrin and metalloproteinase domain-containing protein 8 isoform X6

    Conserved Domains (6) summary
    smart00050
    Location:414 → 488
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:491 → 608
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:616 → 645
    EGF_2; EGF-like domain
    pfam01421
    Location:197 → 397
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:53 → 155
    Pep_M12B_propep; Reprolysin family propeptide
    cl25751
    Location:697 → 834
    DUF4045; Domain of unknown function (DUF4045)

  6. XM_005225706.5 → XP_005225763.2  disintegrin and metalloproteinase domain-containing protein 8 isoform X4

    Conserved Domains (5) summary
    smart00050
    Location:414 → 488
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:491 → 608
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:616 → 645
    EGF_2; EGF-like domain
    pfam01421
    Location:197 → 397
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:53 → 155
    Pep_M12B_propep; Reprolysin family propeptide

  7. XM_005225707.5 → XP_005225764.2  disintegrin and metalloproteinase domain-containing protein 8 isoform X5

    UniProtKB/TrEMBL
    F1MIY8
    Conserved Domains (6) summary
    smart00050
    Location:414 → 488
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:491 → 608
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:616 → 645
    EGF_2; EGF-like domain
    pfam01421
    Location:197 → 397
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:53 → 155
    Pep_M12B_propep; Reprolysin family propeptide
    cl26386
    Location:715 → 839
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  8. XM_005225710.5 → XP_005225767.2  disintegrin and metalloproteinase domain-containing protein 8 isoform X7

    UniProtKB/TrEMBL
    A0A3Q1NKZ8
    Conserved Domains (5) summary
    smart00050
    Location:414 → 488
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:491 → 608
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:616 → 645
    EGF_2; EGF-like domain
    pfam01421
    Location:197 → 397
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:53 → 155
    Pep_M12B_propep; Reprolysin family propeptide

  9. XM_059882035.1 → XP_059738018.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X9

  10. XM_059882036.1 → XP_059738019.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X10

RNA

  1. XR_009492993.1 RNA Sequence

  2. XR_009492994.1 RNA Sequence

Nucleotide Protein Strain
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