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Bcl2l14 Bcl2-like 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500348, updated on 5-Mar-2024

Summary

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Official Symbol
Bcl2l14provided by RGD
Official Full Name
Bcl2-like 14provided by RGD
Primary source
RGD:1562777
See related
Ensembl:ENSRNOG00000028632 AllianceGenome:RGD:1562777
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in apoptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in cytosol. Orthologous to human BCL2L14 (BCL2 like 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 162.3), Lung (RPKM 35.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q43
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (168948919..168989450)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (167217561..167258723)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168139964..168183726)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ETS variant transcription factor 6 Neighboring gene uncharacterized LOC120102413 Neighboring gene uncharacterized LOC134486853 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene LDL receptor related protein 6 Neighboring gene uncharacterized LOC102551409

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression mapping at 12p12-13 in advanced prostate carcinoma. Kibel AS, et al. Int J Cancer, 2004 May 1. PMID 14999772
  2. Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. Lin ML, et al. Breast Cancer Res, 2007. PMID 17280616, Free PMC Article
  3. Bcl-G, a novel pro-apoptotic member of the Bcl-2 family. Guo B, et al. J Biol Chem, 2001 Jan 26. PMID 11054413
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
apoptosis facilitator Bcl-2-like protein 14
Names
Bcl2-like 14 (apoptosis facilitator)
bcl2-L-14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024338.1 → NP_001019509.1  apoptosis facilitator Bcl-2-like protein 14

    See identical proteins and their annotated locations for NP_001019509.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079010
    UniProtKB/Swiss-Prot
    Q6AYK4
    UniProtKB/TrEMBL
    A6IMD0
    Related
    ENSRNOP00000029468.3, ENSRNOT00000032229.6
    Conserved Domains (1) summary
    TIGR00865
    Location:291 → 320
    bcl-2; apoptosis regulator

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    168948919..168989450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237533.4 → XP_006237595.1  apoptosis facilitator Bcl-2-like protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006237595.1

    UniProtKB/Swiss-Prot
    Q6AYK4
    UniProtKB/TrEMBL
    A6IMD0
    Conserved Domains (1) summary
    TIGR00865
    Location:291 → 320
    bcl-2; apoptosis regulator

  2. XM_039108221.2 → XP_038964149.1  apoptosis facilitator Bcl-2-like protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYK4
    UniProtKB/TrEMBL
    A6IMD0
    Conserved Domains (1) summary
    TIGR00865
    Location:291 → 320
    bcl-2; apoptosis regulator

  3. XM_017592836.3 → XP_017448325.1  apoptosis facilitator Bcl-2-like protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYK4
    UniProtKB/TrEMBL
    A6IMD0
    Conserved Domains (1) summary
    TIGR00865
    Location:291 → 320
    bcl-2; apoptosis regulator

  4. XM_006237534.5 → XP_006237596.1  apoptosis facilitator Bcl-2-like protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006237596.1

    UniProtKB/Swiss-Prot
    Q6AYK4
    UniProtKB/TrEMBL
    A6IMD0
    Conserved Domains (1) summary
    TIGR00865
    Location:291 → 320
    bcl-2; apoptosis regulator
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYK4.1 GenPept UniProtKB/Swiss-Prot:Q6AYK4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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