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prkcaa protein kinase C, alpha, a [ Danio rerio (zebrafish) ]

Gene ID: 497384, updated on 21-Apr-2024

Summary

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Official Symbol
prkcaaprovided by ZNC
Official Full Name
protein kinase C, alpha, aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-100
See related
Ensembl:ENSDARG00000115657 AllianceGenome:ZFIN:ZDB-GENE-050208-100
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prkca; im:7139045; si:dkey-8l19.1
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood coagulation. Predicted to be located in mitochondrial membrane; nucleus; and plasma membrane. Is expressed in EVL; hatching gland; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 6
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (21227828..21393927)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (19167656..19330214)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene obscurin like cytoskeletal adaptor 1a Neighboring gene cell death inducing DFFA like effector c Neighboring gene uncharacterized LOC110439882 Neighboring gene calcium channel, voltage-dependent, gamma subunit 5a Neighboring gene calcium channel, voltage-dependent, gamma subunit 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects. Hu R, et al. Circ Genom Precis Med, 2018 Mar. PMID 29540468, Free PMC Article
  2. A Zebrafish Model of Retinitis Pigmentosa Shows Continuous Degeneration and Regeneration of Rod Photoreceptors. Santhanam A, et al. Cells, 2020 Oct 6. PMID 33036185, Free PMC Article
  3. Phylogeny and distribution of protein kinase C variants in the zebrafish. Haug MF, et al. J Comp Neurol, 2018 May 1. PMID 29341136
  4. New transgenic reporters identify somatosensory neuron subtypes in larval zebrafish. Palanca AM, et al. Dev Neurobiol, 2013 Feb. PMID 22865660, Free PMC Article
  5. Antithrombotic effect and action mechanism of Salvia miltiorrhiza and Panax notoginseng herbal pair on the zebrafish. Yin SJ, et al. Chin Med, 2020. PMID 32322295, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein kinase C alpha type; protein kinase C, alpha, a
NP_001243170.1
XP_021332537.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256241.1 → NP_001243170.1  protein kinase C, alpha, a

    Status: PROVISIONAL

    Source sequence(s)
    BX936378, CR759902
    UniProtKB/TrEMBL
    A0A2R8QIY5, A0A8M1NZE8
    Related
    ENSDARP00000155195.1, ENSDART00000193583.1
    Conserved Domains (4) summary
    cd04026
    Location:157 → 287
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:337 → 595
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05615
    Location:326 → 666
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    pfam00130
    Location:100 → 150
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    21227828..21393927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476862.1 → XP_021332537.1  protein kinase C alpha type isoform X1

    UniProtKB/TrEMBL
    A0A8M9PM31
    Conserved Domains (3) summary
    cd04026
    Location:157 → 287
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:335 → 675
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    pfam00130
    Location:100 → 150
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394634.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    11841..173787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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