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tcdB glycosylating toxin TcdB [ Clostridioides difficile 630 ]

Gene ID: 4914074, discontinued on 3-Apr-2020
  • This record was discontinued.

Summary

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Gene symbol
tcdB
Gene description
glycosylating toxin TcdB
Locus tag
CD630_RS03865
Gene type
protein coding
Organism
Clostridioides difficile 630 (strain: 630)
Lineage
Bacteria; Firmicutes; Clostridia; Clostridiales; Peptostreptococcaceae; Clostridioides
Also known as
toxB
Old locus tag
CD630_06600
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Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009089.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A 3.87-A-resolution crystal structure of TcdB holotoxin captures a unique conformation of TcdB at endosomal pH. The C-terminal combined repetitive oligopeptides (CROPs) domain of TcdB is dynamic and can sample open and closed conformations. 3 crystal structures of TcdB-antibody complexes that reveal how antibodies could specifically inhibit the activities of individual TcdB domains.
    Title: Structure of the full-length Clostridium difficile toxin B.
  2. These data demonstrate that RstA is a transcriptional repressor that autoregulates its own expression and directly inhibits transcription of the TcdA and the TcdB toxin genes and two positive toxin regulators, thereby acting at multiple regulatory points to control toxin production.
    Title: RstA Is a Major Regulator of Clostridioides difficile Toxin Production and Motility.
  3. Cell-penetrating peptides derived from Clostridium difficile TcdB2 and a related large clostridial toxin.
    Title: Cell-penetrating peptides derived from Clostridium difficile TcdB2 and a related large clostridial toxin.
  4. determined five different structures of the TcdA and TcdB glucosyltransferase domains and made use of a non-hydrolyzable UDP-glucose substrate
    Title: Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
  5. In addition to establishing the binding region for CSPG4, this work ascribes for the first time a role in TcdB CROPs in receptor binding and further clarifies the relative roles of host receptors in TcdB pathogenesis.
    Title: Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.
  6. combination vaccine elicits high neutralizing antibody titers against TcdA, TcdB and binary toxin in both hamsters and rhesus macaques. Taken together, these data strongly support the inclusion of binary toxin in a vaccine against Clostridium difficile i to provide enhanced protection from epidemic strains of C. difficile.
    Title: Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains.
  7. Data identified a mutation in mfd gene resulting in abnormal colony morphology and a large increase in the production of toxins A and B. Increased transcription of tcdA and tcdB genes in the mfd mutant suggests a relief of transcriptional repression.
    Title: Increased toxin expression in a Clostridium difficile mfd mutant.
  8. Data suggest that 3 independent regions of TcdB (1372-1493, 1493-1848, 1851-2366) contribute to binding and entry of TcdB into mammalian cells; residues 1372-1493 are sufficient for interaction with PVRL3 (poliovirus receptor-related 3 protein).
    Title: Binding and entry of Clostridium difficile toxin B is mediated by multiple domains.
  9. These studies indicate how key epitopes in the RBDs from TcdA and TcdB are recognized by sdAbs, providing molecular insights into toxin structure and function
    Title: Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile.
  10. These findings indicate TcdB027 is a more potent toxin than TcdB003 as measured by lethality assays and pathology, moreover the sequence differences between the two forms of TcdB alter antigenic epitopes
    Title: Clostridium difficile 027/BI/NAP1 encodes a hypertoxic and antigenically variable form of TcdB.
Submit: New GeneRIF Correction See all GeneRIFs (22)

General protein information

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Preferred Names
glycosylating toxin TcdB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009089.1 Reference assembly

    Range
    787393..794493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_009902069.1 glycosylating toxin TcdB [Clostridioides difficile]

    See identical proteins and their annotated locations for WP_009902069.1

Nucleotide Protein
Heading Accession and Version

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