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PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 [ Canis lupus familiaris (dog) ]

Gene ID: 489571, updated on 5-Mar-2024

Summary

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Official Symbol
PRKAA2provided by VGNC
Official Full Name
protein kinase AMP-activated catalytic subunit alpha 2provided by VGNC
Primary source
VGNC:VGNC:53435
See related
Ensembl:ENSCAFG00845013807
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See PRKAA2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (52996830..53064324, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (52877206..52944655, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (53172006..53239515, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (52940854..53008285, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (52886688..52954140, complement)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene complement C8 alpha chain Neighboring gene 40S ribosomal protein S3a-like Neighboring gene FYN binding protein 2 Neighboring gene uncharacterized LOC102156441 Neighboring gene uncharacterized LOC111096115

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vasopressin regulates the phosphorylation state of AMP-activated protein kinase (AMPK) in MDCK-C7 cells. Nofziger C, et al. Cell Physiol Biochem, 2008. PMID 19088430
  2. Skeletal muscle basal AMP-activated protein kinase activity is chronically elevated in alloxan-diabetic dogs: impact of exercise. Christopher MJ, et al. J Appl Physiol (1985), 2003 Oct. PMID 12832424

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
5'-AMP-activated protein kinase catalytic subunit alpha-2
Names
AMPKalpha2
XP_013969238.1
XP_038332167.1
XP_038332168.1
XP_038332169.1
XP_038376446.1
XP_038376465.1
XP_038393347.1
XP_038393348.1
XP_038393349.1
XP_038457482.1
XP_038457483.1
XP_038457484.1
XP_038522050.1
XP_038522051.1
XP_038522052.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    52996830..53064324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038666122.1 → XP_038522050.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0M2F3, A0A8C0R002, A0A8I3NR33
    Related
    ENSCAFP00845019377.1, ENSCAFT00845024631.1
    Conserved Domains (3) summary
    cd12200
    Location:395 → 550
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    cd14404
    Location:285 → 349
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cd14079
    Location:13 → 268
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  2. XM_038666123.1 → XP_038522051.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2

    Conserved Domains (3) summary
    cd12200
    Location:305 → 460
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    cd14404
    Location:195 → 259
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cl21453
    Location:1 → 178
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038666124.1 → XP_038522052.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X3

    Conserved Domains (1) summary
    cd14079
    Location:13 → 263
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

RNA

  1. XR_005427329.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    52940854..53008285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038476239.1 → XP_038332167.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1

    Conserved Domains (3) summary
    cd12200
    Location:395 → 550
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    cd14404
    Location:285 → 349
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cd14079
    Location:13 → 268
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  2. XM_038476240.1 → XP_038332168.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2

    Conserved Domains (3) summary
    cd12200
    Location:305 → 460
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    cd14404
    Location:195 → 259
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cl21453
    Location:1 → 178
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038476241.1 → XP_038332169.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X3

    Conserved Domains (1) summary
    cd14079
    Location:13 → 263
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

RNA

  1. XR_005325853.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    52886688..52954140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038601554.1 → XP_038457482.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1

    Conserved Domains (3) summary
    cd12200
    Location:395 → 550
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    cd14404
    Location:285 → 349
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cd14079
    Location:13 → 268
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  2. XM_038601555.1 → XP_038457483.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2

    Conserved Domains (3) summary
    cd12200
    Location:305 → 460
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    cd14404
    Location:195 → 259
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cl21453
    Location:1 → 178
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038601556.1 → XP_038457484.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X3

    Conserved Domains (1) summary
    cd14079
    Location:13 → 263
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

RNA

  1. XR_005394269.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    53172006..53239515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038537419.1 → XP_038393347.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0M2F3, A0A8C0R002, A0A8I3NR33
    Conserved Domains (3) summary
    cd12200
    Location:395 → 550
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    cd14404
    Location:285 → 349
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cd14079
    Location:13 → 268
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  2. XM_038537420.1 → XP_038393348.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2

    Conserved Domains (3) summary
    cd12200
    Location:305 → 460
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    cd14404
    Location:195 → 259
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cl21453
    Location:1 → 178
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038537421.1 → XP_038393349.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X3

    Conserved Domains (1) summary
    cd14079
    Location:13 → 263
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

RNA

  1. XR_005359722.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    52877206..52944655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038520518.1 → XP_038376446.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0M2F3, A0A8C0R002, A0A8I3NR33
    Conserved Domains (3) summary
    cd12200
    Location:395 → 550
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    cd14404
    Location:285 → 349
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cd14079
    Location:13 → 268
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  2. XM_014113763.3 → XP_013969238.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2

    UniProtKB/TrEMBL
    F1PIW7
    Conserved Domains (3) summary
    cd12200
    Location:305 → 460
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    cd14404
    Location:195 → 259
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cl21453
    Location:1 → 178
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038520537.1 → XP_038376465.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X3

    Conserved Domains (1) summary
    cd14079
    Location:13 → 263
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

RNA

  1. XR_005350325.1 RNA Sequence

Nucleotide Protein
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