BAK1 BCL2 antagonist/killer 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: BAK1provided by VGNC
Official Full Name: BCL2 antagonist/killer 1provided by VGNC
Primary source: VGNC:VGNC:38375
See related: Ensembl:ENSCAFG00845023547
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	12	NC_051816.1 (3282315..3289076, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	12	NC_006594.4 (2967686..2970924, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	12	NC_049233.1 (3129752..3132990, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	12	NC_049272.1 (2950651..2953887, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	12	NC_049753.1 (3031622..3034860, complement)

Chromosome 12 - NC_051816.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both Bax and Bak are widely expressed in non-neoplastic tissues from adult dogs. Immunohistochemistry showed almost exclusively cytoplasmic labelling and prominent labelling of epithelial cells.
Title: Immunohistochemical expression of Bax and Bak in canine non-neoplastic tissues.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: bcl-2 homologous antagonist/killer

Names: bcl-2 homologous antagonist/killer-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020808.1 → NP_001018644.1 bcl-2 homologous antagonist/killer

See identical proteins and their annotated locations for NP_001018644.1

Status: PROVISIONAL

Source sequence(s)

DQ002813

UniProtKB/TrEMBL

A0A8I3PNV6, A0A8P0NX47, Q52HB2

Conserved Domains (1) summary

cd06845
Location:30 → 183

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051816.1 Reference ROS_Cfam_1.0

Range

3282315..3289076 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038682754.1 → XP_038538682.1 bcl-2 homologous antagonist/killer isoform X3

Conserved Domains (1) summary

cd06845
Location:2 → 124

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
XM_038682752.1 → XP_038538680.1 bcl-2 homologous antagonist/killer isoform X1

UniProtKB/TrEMBL

A0A8C0JQK7, A0A8C0QRG0, A0A8I3PJD5, A0A8I3PNV6, A0A8P0NX47

Conserved Domains (1) summary

cd06845
Location:30 → 183

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
XM_038682750.1 → XP_038538678.1 bcl-2 homologous antagonist/killer isoform X1

UniProtKB/TrEMBL

A0A8C0JQK7, A0A8C0QRG0, A0A8I3PJD5, A0A8I3PNV6, A0A8P0NX47

Related

ENSCAFP00845032598.1, ENSCAFT00845041577.1

Conserved Domains (1) summary

cd06845
Location:30 → 183

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
XM_038682751.1 → XP_038538679.1 bcl-2 homologous antagonist/killer isoform X1

UniProtKB/TrEMBL

A0A8C0JQK7, A0A8C0QRG0, A0A8I3PJD5, A0A8I3PNV6, A0A8P0NX47

Conserved Domains (1) summary

cd06845
Location:30 → 183

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
XM_038682753.1 → XP_038538681.1 bcl-2 homologous antagonist/killer isoform X2

UniProtKB/TrEMBL

A0A8I3PNV6, A0A8P0NX47, Q52HB2

Related

ENSCAFP00845032646.1, ENSCAFT00845041630.1

Conserved Domains (1) summary

cd06845
Location:30 → 183

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...