NCF2 neutrophil cytosolic factor 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: NCF2provided by VGNC
Official Full Name: neutrophil cytosolic factor 2provided by VGNC
Primary source: VGNC:VGNC:43650
See related: Ensembl:ENSCAFG00845004665
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	7	NC_051811.1 (16646647..16676710, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	7	NC_006589.4 (16500692..16530126, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	7	NC_049228.1 (16795528..16824986, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	7	NC_049267.1 (16555169..16584783, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	7	NC_049748.1 (16664590..16693979, complement)

Chromosome 7 - NC_051811.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables superoxide-generating NADPH oxidase activator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in respiratory burst	IEA Inferred from Electronic Annotation more info	PubMed
involved_in superoxide anion generation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: neutrophil cytosol factor 2

Names: neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2); predicted neutrophil cytosolic factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101832.1 → NP_001095302.1 neutrophil cytosol factor 2

See identical proteins and their annotated locations for NP_001095302.1

Status: PROVISIONAL

Source sequence(s)

BR000293

UniProtKB/TrEMBL

A0A8C0Q962, A0A8P0NSF2, A7E3N1, F1PDH6, J9P6Z3

Related

ENSCAFP00845006585.1, ENSCAFT00845008369.1

Conserved Domains (7) summary

cd06406
Location:353 → 431

PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...

cd11871
Location:244 → 297

SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase

cd12046
Location:464 → 515

SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase

sd00006
Location:6 → 32

TPR; TPR repeat [structural motif]

pfam00515
Location:71 → 98

TPR_1; Tetratricopeptide repeat

pfam13414
Location:71 → 150

TPR_11; TPR repeat

pfam13424
Location:38 → 102

TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051811.1 Reference ROS_Cfam_1.0

Range

16646647..16676710 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038670516.1 → XP_038526444.1 neutrophil cytosol factor 2 isoform X1

UniProtKB/TrEMBL

A0A8C0Q962, A0A8P0NSF2

Related

ENSCAFP00845006608.1, ENSCAFT00845008396.1

Conserved Domains (5) summary

cd06406
Location:350 → 428

PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...

cd11871
Location:244 → 297

SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase

cd12046
Location:461 → 512

SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase

COG0457
Location:6 → 173

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:6 → 32

TPR; TPR repeat [structural motif]