TDP2 tyrosyl-DNA phosphodiesterase 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: TDP2provided by VGNC
Official Full Name: tyrosyl-DNA phosphodiesterase 2provided by VGNC
Primary source: VGNC:VGNC:47219
See related: Ensembl:ENSCAFG00845020279
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: TTRAP
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 35

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	35	NC_051839.1 (22815655..22829433, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	35	NC_006617.4 (22660843..22674624, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	35	NC_049256.1 (24105036..24118785, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	35	NC_049295.1 (22621127..22634899, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	35	NC_049776.1 (22668709..22682476, complement)

Chromosome 35 - NC_051839.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 5'-tyrosyl-DNA phosphodiesterase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in double-strand break repair	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 5'-tyrosyl-DNA phosphodiesterase; tyrosyl-DNA phosphodiesterase 2

Names: TRAF and TNF receptor associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051839.1 Reference ROS_Cfam_1.0

Range

22815655..22829433 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038446488.1 → XP_038302416.1 tyrosyl-DNA phosphodiesterase 2

UniProtKB/TrEMBL

A0A8C0NK44, A0A8I3P722

Related

ENSCAFP00845027935.1, ENSCAFT00845035706.1

Conserved Domains (2) summary

cd09080
Location:117 → 361

TDP2; Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains

cd14344
Location:18 → 54

UBA_TYDP2; UBA-like domain found in tyrosyl-DNA phosphodiesterase 2 (TDP2) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

NC_049295.1 Alternate UMICH_Zoey_3.1

Range

22621127..22634899 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038520623.1 → XP_038376551.1 tyrosyl-DNA phosphodiesterase 2

Conserved Domains (2) summary

cd09080
Location:113 → 357

TDP2; Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains

cd14344
Location:18 → 54

UBA_TYDP2; UBA-like domain found in tyrosyl-DNA phosphodiesterase 2 (TDP2) and similar proteins

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049776.1 Alternate UNSW_CanFamBas_1.0

Range

22668709..22682476 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038648692.1 → XP_038504620.1 tyrosyl-DNA phosphodiesterase 2

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049256.1 Alternate UU_Cfam_GSD_1.0

Range

24105036..24118785 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038584282.1 → XP_038440210.1 tyrosyl-DNA phosphodiesterase 2

UniProtKB/TrEMBL

A0A8C0NK44, A0A8P0SF85

Conserved Domains (2) summary

cd09080
Location:113 → 357

TDP2; Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains

cd14344
Location:18 → 54

UBA_TYDP2; UBA-like domain found in tyrosyl-DNA phosphodiesterase 2 (TDP2) and similar proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006617.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

22660843..22674624 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038463118.1 → XP_038319046.1 tyrosyl-DNA phosphodiesterase 2

UniProtKB/TrEMBL

A0A8C0NK44, A0A8P0SF85

Conserved Domains (2) summary

cd09080
Location:113 → 357

TDP2; Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains

cd14344
Location:18 → 54

UBA_TYDP2; UBA-like domain found in tyrosyl-DNA phosphodiesterase 2 (TDP2) and similar proteins