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GSK3B glycogen synthase kinase 3 beta [ Canis lupus familiaris (dog) ]

Gene ID: 478575, updated on 5-Mar-2024

Summary

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Official Symbol
GSK3Bprovided by VGNC
Official Full Name
glycogen synthase kinase 3 betaprovided by VGNC
Primary source
VGNC:VGNC:41530
See related
Ensembl:ENSCAFG00845017754
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 33
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 33 NC_051837.1 (23696164..23823688, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 33 NC_006615.4 (23488457..23689804, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 33 NC_049254.1 (24104403..24306119, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 33 NC_049293.1 (23500322..23702303, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 33 NC_049774.1 (23541326..23742436, complement)

Chromosome 33 - NC_051837.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 91 Neighboring gene uncharacterized LOC106558176 Neighboring gene 60S ribosomal protein L27a-like Neighboring gene nuclear receptor subfamily 1 group I member 2 Neighboring gene small nucleolar RNA U3 Neighboring gene serine/arginine repetitive matrix protein 3-like Neighboring gene microRNA mir-6529

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β. Kirk JA, et al. J Clin Invest, 2014 Jan. PMID 24292707, Free PMC Article
  2. AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane. Zhang L, et al. J Biol Chem, 2011 May 13. PMID 21383016, Free PMC Article
  3. Helicobacter pylori suppresses glycogen synthase kinase 3beta to promote beta-catenin activity. Sokolova O, et al. J Biol Chem, 2008 Oct 24. PMID 18772141, Free PMC Article
  4. Oral administration of a GSK3 inhibitor increases brain insulin-like growth factor I levels. Bolós M, et al. J Biol Chem, 2010 Jun 4. PMID 20351102, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cardiac resynchronization therapy improves calcium responsiveness of myofilaments following heart failure through GSK-3beta reactivation.
    Title: Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β.
  2. AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3beta (GSK-3beta) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane
    Title: AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane.
  3. inhibiting GSK3 increases brain insulin-like growth factor I levels
    Title: Oral administration of a GSK3 inhibitor increases brain insulin-like growth factor I levels.
  4. glycogen synthase kinase 3beta activity exerts an important role in beta-catenin regulation and LEF/TCF transactivation in H. pylori-infected Madin-Darby canine kidney cells
    Title: Helicobacter pylori suppresses glycogen synthase kinase 3beta to promote beta-catenin activity.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tau-protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of beta-catenin destruction complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
glycogen synthase kinase-3 beta
XP_005639593.1
XP_038301303.1
XP_038375261.1
XP_038375262.1
XP_038375263.1
XP_038438882.1
XP_038438884.1
XP_038438885.1
XP_038503270.1
XP_038503271.1
XP_038503272.1
XP_535751.2
XP_856611.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051837.1 Reference ROS_Cfam_1.0

    Range
    23696164..23823688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038445375.1 → XP_038301303.1  glycogen synthase kinase-3 beta isoform X1

    UniProtKB/TrEMBL
    A0A8I3P4F2
    Related
    ENSCAFP00845024619.1, ENSCAFT00845031438.1
    Conserved Domains (1) summary
    cd14137
    Location:17 → 279
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049293.1 Alternate UMICH_Zoey_3.1

    Range
    23500322..23702303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038519335.1 → XP_038375263.1  glycogen synthase kinase-3 beta isoform X4

    Conserved Domains (1) summary
    cd14137
    Location:51 → 356
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

  2. XM_038519333.1 → XP_038375261.1  glycogen synthase kinase-3 beta isoform X2

    Conserved Domains (1) summary
    cd14137
    Location:51 → 356
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

  3. XM_038519334.1 → XP_038375262.1  glycogen synthase kinase-3 beta isoform X3

    Conserved Domains (1) summary
    cd14137
    Location:51 → 343
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049774.1 Alternate UNSW_CanFamBas_1.0

    Range
    23541326..23742436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038647343.1 → XP_038503271.1  glycogen synthase kinase-3 beta isoform X6

    Conserved Domains (1) summary
    cd14137
    Location:51 → 343
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

  2. XM_038647342.1 → XP_038503270.1  glycogen synthase kinase-3 beta isoform X5

    Conserved Domains (1) summary
    cd14137
    Location:51 → 356
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

  3. XM_038647344.1 → XP_038503272.1  glycogen synthase kinase-3 beta isoform X7

    Conserved Domains (1) summary
    cd14137
    Location:51 → 356
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049254.1 Alternate UU_Cfam_GSD_1.0

    Range
    24104403..24306119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038582957.1 → XP_038438885.1  glycogen synthase kinase-3 beta isoform X10

    UniProtKB/TrEMBL
    A0A8P0ND25, A0A8P0NMG8
    Conserved Domains (1) summary
    cd14137
    Location:51 → 356
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

  2. XM_038582954.1 → XP_038438882.1  glycogen synthase kinase-3 beta isoform X8

    UniProtKB/TrEMBL
    A0A8C0MPF2, A0A8C0QWC0, A0A8P0ND25, A0A8P0PIC9
    Conserved Domains (1) summary
    cd14137
    Location:51 → 356
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

  3. XM_038582956.1 → XP_038438884.1  glycogen synthase kinase-3 beta isoform X9

    UniProtKB/TrEMBL
    A0A8C0JYA2, A0A8C0JZY6, A0A8C0T8A0
    Conserved Domains (1) summary
    cd14137
    Location:51 → 343
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006615.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    23488457..23689804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005639536.4 → XP_005639593.1  glycogen synthase kinase-3 beta isoform X13

    See identical proteins and their annotated locations for XP_005639593.1

    UniProtKB/TrEMBL
    A0A8P0ND25, A0A8P0NMG8
    Conserved Domains (1) summary
    cd14137
    Location:51 → 356
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

  2. XM_535751.7 → XP_535751.2  glycogen synthase kinase-3 beta isoform X11

    See identical proteins and their annotated locations for XP_535751.2

    UniProtKB/TrEMBL
    A0A8C0MPF2, A0A8C0QWC0, A0A8P0ND25, A0A8P0PIC9
    Conserved Domains (1) summary
    cd14137
    Location:51 → 356
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

  3. XM_851518.6 → XP_856611.1  glycogen synthase kinase-3 beta isoform X12

    See identical proteins and their annotated locations for XP_856611.1

    UniProtKB/TrEMBL
    A0A8C0JYA2, A0A8C0JZY6, A0A8C0T8A0
    Conserved Domains (1) summary
    cd14137
    Location:51 → 343
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
Nucleotide Protein
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