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HTRA4 HtrA serine peptidase 4 [ Canis lupus familiaris (dog) ]

Gene ID: 475580, updated on 5-Mar-2024

Summary

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Official Symbol
HTRA4provided by VGNC
Official Full Name
HtrA serine peptidase 4provided by VGNC
Primary source
VGNC:VGNC:41838
See related
Ensembl:ENSCAFG00845011352
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (28387990..28399796, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (27077924..27089718, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (27296714..27308507, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (26683757..26693477, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (27258412..27270186, complement)

Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 32 Neighboring gene microRNA mir-8799d Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene TM2 domain containing 2 Neighboring gene pleckstrin homology domain containing A2 Neighboring gene transforming acidic coiled-coil containing protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in programmed cell death IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
probable serine protease HTRA4; LOW QUALITY PROTEIN: serine protease HTRA4; serine protease HTRA4
Names
serine protease HTR4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051820.1 Reference ROS_Cfam_1.0

    Range
    28387990..28399796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038689819.1 → XP_038545747.1  serine protease HTRA4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NHG2
    Conserved Domains (3) summary
    smart00280
    Location:112 → 138
    KAZAL; Kazal type serine protease inhibitors
    COG0265
    Location:163 → 466
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    pfam00219
    Location:39 → 93
    IGFBP; Insulin-like growth factor binding protein

  2. XM_038689818.1 → XP_038545746.1  serine protease HTRA4 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NHG2
    Related
    ENSCAFP00845015784.1, ENSCAFT00845020135.1
    Conserved Domains (3) summary
    smart00280
    Location:112 → 138
    KAZAL; Kazal type serine protease inhibitors
    TIGR02037
    Location:174 → 476
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    pfam00219
    Location:39 → 93
    IGFBP; Insulin-like growth factor binding protein

  3. XM_038689821.1 → XP_038545749.1  serine protease HTRA4 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NHG2
    Conserved Domains (3) summary
    smart00280
    Location:112 → 138
    KAZAL; Kazal type serine protease inhibitors
    COG0265
    Location:163 → 401
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    pfam00219
    Location:39 → 93
    IGFBP; Insulin-like growth factor binding protein

RNA

  1. XR_005439198.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049276.1 Alternate UMICH_Zoey_3.1

    Range
    26683757..26693477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038497574.1 → XP_038353502.1  LOW QUALITY PROTEIN: serine protease HTRA4 isoform X3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

    Range
    27258412..27270186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038624069.1 → XP_038479997.1  LOW QUALITY PROTEIN: serine protease HTRA4 isoform X3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

    Range
    27296714..27308507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038560024.1 → XP_038415952.1  serine protease HTRA4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NHG2

  2. XM_038560023.1 → XP_038415951.1  serine protease HTRA4 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NHG2

  3. XM_038560025.1 → XP_038415953.1  serine protease HTRA4 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NHG2

RNA

  1. XR_005371454.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    27077924..27089718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038452857.1 → XP_038308785.1  serine protease HTRA4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NHG2
    Conserved Domains (3) summary
    smart00280
    Location:112 → 138
    KAZAL; Kazal type serine protease inhibitors
    COG0265
    Location:163 → 466
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    pfam00219
    Location:39 → 93
    IGFBP; Insulin-like growth factor binding protein

  2. XM_005629920.4 → XP_005629977.3  serine protease HTRA4 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NHG2
    Conserved Domains (3) summary
    smart00280
    Location:112 → 138
    KAZAL; Kazal type serine protease inhibitors
    TIGR02037
    Location:174 → 476
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    pfam00219
    Location:39 → 93
    IGFBP; Insulin-like growth factor binding protein

  3. XM_038452858.1 → XP_038308786.1  serine protease HTRA4 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NHG2
    Conserved Domains (3) summary
    smart00280
    Location:112 → 138
    KAZAL; Kazal type serine protease inhibitors
    COG0265
    Location:163 → 401
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    pfam00219
    Location:39 → 93
    IGFBP; Insulin-like growth factor binding protein

RNA

  1. XR_005310889.1 RNA Sequence

Nucleotide Protein
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