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DST dystonin [ Canis lupus familiaris (dog) ]

Gene ID: 474948, updated on 5-Mar-2024

Summary

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Official Symbol
DSTprovided by VGNC
Official Full Name
dystoninprovided by VGNC
Primary source
VGNC:VGNC:57222
See related
Ensembl:ENSCAFG00845012662
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
BPAG1
Orthologs
human mouse all
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Genomic context

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See DST in Genome Data Viewer
Location:
chromosome: 12
Exon count:
109
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (24213304..24693512, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (23605476..24084492, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (23943092..24423680, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (23705703..24191186, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (23812683..24292223, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119880259 Neighboring gene chloride intracellular channel 1 pseudogene Neighboring gene uncharacterized LOC111098294 Neighboring gene uncharacterized LOC119874187 Neighboring gene cytochrome c oxidase assembly protein COX20, mitochondrial-like Neighboring gene transcription factor BTF3-like Neighboring gene calmodulin-A-like Neighboring gene BEN domain containing 6 Neighboring gene KIAA1586 ortholog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Physical and radiation hybrid mapping of canine chromosome 12, in a region corresponding to human chromosome 6p12-q12. Li R, et al. Genomics, 2001 May 1. PMID 11350122

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables keratin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemidesmosome assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intermediate filament bundle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in skin development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in hemidesmosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intercalated disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dystonin
Names
bullous pemphigoid antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    24213304..24693512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038683836.1 → XP_038539764.1  dystonin isoform X27

    UniProtKB/TrEMBL
    A0A8C0R223
    Conserved Domains (13) summary
    smart00243
    Location:7457 → 7529
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:796 → 887
    SPEC; Spectrin repeats
    smart00250
    Location:1740 → 1771
    PLEC; Plectin repeat
    COG0419
    Location:4959 → 5518
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3789 → 4602
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7382 → 7444
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6561 → 6775
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1962 → 2001
    Plectin; Plectin repeat
    pfam17902
    Location:1064 → 1130
    SH3_10; SH3 domain
    pfam18373
    Location:1165 → 1242
    Spectrin_like; Spectrin like domain
    cd21236
    Location:210 → 334
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:339 → 442
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl02488
    Location:1382 → 1546
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  2. XM_038683821.1 → XP_038539749.1  dystonin isoform X13

    UniProtKB/TrEMBL
    A0A8P0NZC6
    Conserved Domains (13) summary
    smart00243
    Location:7381 → 7456
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    COG0419
    Location:4992 → 5551
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3822 → 4635
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7306 → 7368
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6485 → 6699
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2034
    Plectin; Plectin repeat
    pfam17902
    Location:1097 → 1163
    SH3_10; SH3 domain
    pfam18373
    Location:1198 → 1275
    Spectrin_like; Spectrin like domain
    cd21239
    Location:372 → 475
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:210 → 367
    CH_SF; calponin homology (CH) domain superfamily
    cl02488
    Location:1415 → 1579
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  3. XM_038683815.1 → XP_038539743.1  dystonin isoform X7

    UniProtKB/TrEMBL
    A0A8C0SRD4
    Conserved Domains (13) summary
    smart00243
    Location:7490 → 7562
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    COG0419
    Location:4992 → 5551
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3822 → 4635
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7415 → 7477
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6594 → 6808
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2034
    Plectin; Plectin repeat
    pfam17902
    Location:1097 → 1163
    SH3_10; SH3 domain
    pfam18373
    Location:1198 → 1275
    Spectrin_like; Spectrin like domain
    cd21239
    Location:372 → 475
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:210 → 367
    CH_SF; calponin homology (CH) domain superfamily
    cl02488
    Location:1415 → 1579
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  4. XM_038683811.1 → XP_038539739.1  dystonin isoform X3

    UniProtKB/TrEMBL
    A0A8C0SPZ3
    Conserved Domains (13) summary
    smart00243
    Location:7490 → 7559
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    COG0419
    Location:4992 → 5551
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3822 → 4635
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7415 → 7477
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6594 → 6808
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2034
    Plectin; Plectin repeat
    pfam17902
    Location:1097 → 1163
    SH3_10; SH3 domain
    pfam18373
    Location:1198 → 1275
    Spectrin_like; Spectrin like domain
    cd21239
    Location:372 → 475
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:210 → 367
    CH_SF; calponin homology (CH) domain superfamily
    cl02488
    Location:1415 → 1579
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  5. XM_038683818.1 → XP_038539746.1  dystonin isoform X10

    UniProtKB/TrEMBL
    A0A8C0SPZ3
    Conserved Domains (14) summary
    smart00243
    Location:7490 → 7565
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    PHA03307
    Location:7629 → 7784
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:4992 → 5551
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3822 → 4635
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7415 → 7477
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6594 → 6808
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2034
    Plectin; Plectin repeat
    pfam17902
    Location:1097 → 1163
    SH3_10; SH3 domain
    pfam18373
    Location:1198 → 1275
    Spectrin_like; Spectrin like domain
    cd21239
    Location:372 → 475
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:210 → 367
    CH_SF; calponin homology (CH) domain superfamily
    cl02488
    Location:1415 → 1579
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  6. XM_038683809.1 → XP_038539737.1  dystonin isoform X1

    UniProtKB/TrEMBL
    A0A8C0SPZ3
    Conserved Domains (13) summary
    smart00243
    Location:7490 → 7565
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    COG0419
    Location:4992 → 5551
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3822 → 4635
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7415 → 7477
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6594 → 6808
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2034
    Plectin; Plectin repeat
    pfam17902
    Location:1097 → 1163
    SH3_10; SH3 domain
    pfam18373
    Location:1198 → 1275
    Spectrin_like; Spectrin like domain
    cd21239
    Location:372 → 475
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:210 → 367
    CH_SF; calponin homology (CH) domain superfamily
    cl02488
    Location:1415 → 1579
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  7. XM_038683819.1 → XP_038539747.1  dystonin isoform X11

    UniProtKB/TrEMBL
    A0A8C0SQB1
    Conserved Domains (13) summary
    smart00243
    Location:7448 → 7523
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:787 → 878
    SPEC; Spectrin repeats
    smart00250
    Location:1731 → 1762
    PLEC; Plectin repeat
    COG0419
    Location:4950 → 5509
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3780 → 4593
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7373 → 7435
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6552 → 6766
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1953 → 1992
    Plectin; Plectin repeat
    pfam17902
    Location:1055 → 1121
    SH3_10; SH3 domain
    pfam18373
    Location:1156 → 1233
    Spectrin_like; Spectrin like domain
    cd21236
    Location:201 → 325
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:330 → 433
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl02488
    Location:1373 → 1537
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  8. XM_038683828.1 → XP_038539756.1  dystonin isoform X20

    UniProtKB/TrEMBL
    A0A8I3RXI6
    Conserved Domains (11) summary
    pfam05483
    Location:1365 → 2001
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:5383 → 5461
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:796 → 887
    SPEC; Spectrin repeats
    COG0419
    Location:2885 → 3444
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5308 → 5370
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4487 → 4701
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1699 → 2528
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:1064 → 1130
    SH3_10; SH3 domain
    pfam18373
    Location:1165 → 1242
    Spectrin_like; Spectrin like domain
    cd21236
    Location:210 → 334
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:339 → 442
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  9. XM_038683816.1 → XP_038539744.1  dystonin isoform X8

    UniProtKB/TrEMBL
    A0A8C0SQB1
    Conserved Domains (13) summary
    smart00243
    Location:7457 → 7532
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:796 → 887
    SPEC; Spectrin repeats
    smart00250
    Location:1740 → 1771
    PLEC; Plectin repeat
    COG0419
    Location:4959 → 5518
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3789 → 4602
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7382 → 7444
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6561 → 6775
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1962 → 2001
    Plectin; Plectin repeat
    pfam17902
    Location:1064 → 1130
    SH3_10; SH3 domain
    pfam18373
    Location:1165 → 1242
    Spectrin_like; Spectrin like domain
    cd21236
    Location:210 → 334
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:339 → 442
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl02488
    Location:1382 → 1546
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  10. XM_038683813.1 → XP_038539741.1  dystonin isoform X5

    UniProtKB/TrEMBL
    A0A8C0SPZ3
    Conserved Domains (13) summary
    smart00243
    Location:7469 → 7544
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:808 → 899
    SPEC; Spectrin repeats
    smart00250
    Location:1752 → 1783
    PLEC; Plectin repeat
    COG0419
    Location:4971 → 5530
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3801 → 4614
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7394 → 7456
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6573 → 6787
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1974 → 2013
    Plectin; Plectin repeat
    pfam17902
    Location:1076 → 1142
    SH3_10; SH3 domain
    pfam18373
    Location:1177 → 1254
    Spectrin_like; Spectrin like domain
    cd21239
    Location:351 → 454
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:210 → 346
    CH_SF; calponin homology (CH) domain superfamily
    cl02488
    Location:1394 → 1558
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  11. XM_038683810.1 → XP_038539738.1  dystonin isoform X2

    UniProtKB/TrEMBL
    A0A8C0SPZ3
    Conserved Domains (13) summary
    smart00243
    Location:7486 → 7561
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1769 → 1800
    PLEC; Plectin repeat
    COG0419
    Location:4988 → 5547
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3818 → 4631
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7411 → 7473
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6590 → 6804
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1991 → 2030
    Plectin; Plectin repeat
    pfam17902
    Location:1097 → 1163
    SH3_10; SH3 domain
    pfam18373
    Location:1198 → 1275
    Spectrin_like; Spectrin like domain
    cd21239
    Location:372 → 475
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:210 → 367
    CH_SF; calponin homology (CH) domain superfamily
    cl02488
    Location:1415 → 1579
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  12. XM_038683822.1 → XP_038539750.1  dystonin isoform X14

    UniProtKB/TrEMBL
    A0A8P0NZC6
    Conserved Domains (14) summary
    smart00243
    Location:7381 → 7456
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    PHA03307
    Location:7520 → 7675
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:4992 → 5551
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3822 → 4635
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7306 → 7368
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6485 → 6699
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2034
    Plectin; Plectin repeat
    pfam17902
    Location:1097 → 1163
    SH3_10; SH3 domain
    pfam18373
    Location:1198 → 1275
    Spectrin_like; Spectrin like domain
    cd21239
    Location:372 → 475
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:210 → 367
    CH_SF; calponin homology (CH) domain superfamily
    cl02488
    Location:1415 → 1579
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  13. XM_038683829.1 → XP_038539757.1  dystonin isoform X21

    UniProtKB/TrEMBL
    A0A8I3RXI6
    Conserved Domains (11) summary
    pfam05483
    Location:1356 → 1992
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:5374 → 5452
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:787 → 878
    SPEC; Spectrin repeats
    COG0419
    Location:2876 → 3435
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5299 → 5361
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4478 → 4692
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1690 → 2519
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:1055 → 1121
    SH3_10; SH3 domain
    pfam18373
    Location:1156 → 1233
    Spectrin_like; Spectrin like domain
    cd21236
    Location:201 → 325
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:330 → 433
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  14. XM_038683817.1 → XP_038539745.1  dystonin isoform X9

    UniProtKB/TrEMBL
    A0A8C0SRD4
    Conserved Domains (13) summary
    smart00243
    Location:7481 → 7559
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:820 → 911
    SPEC; Spectrin repeats
    smart00250
    Location:1764 → 1795
    PLEC; Plectin repeat
    COG0419
    Location:4983 → 5542
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3813 → 4626
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7406 → 7468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6585 → 6799
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1986 → 2025
    Plectin; Plectin repeat
    pfam17902
    Location:1088 → 1154
    SH3_10; SH3 domain
    pfam18373
    Location:1189 → 1266
    Spectrin_like; Spectrin like domain
    cd21239
    Location:363 → 466
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:201 → 358
    CH_SF; calponin homology (CH) domain superfamily
    cl02488
    Location:1406 → 1570
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  15. XM_038683812.1 → XP_038539740.1  dystonin isoform X4

    UniProtKB/TrEMBL
    A0A8C0SPZ3
    Conserved Domains (13) summary
    smart00243
    Location:7481 → 7556
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:820 → 911
    SPEC; Spectrin repeats
    smart00250
    Location:1764 → 1795
    PLEC; Plectin repeat
    COG0419
    Location:4983 → 5542
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3813 → 4626
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7406 → 7468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6585 → 6799
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1986 → 2025
    Plectin; Plectin repeat
    pfam17902
    Location:1088 → 1154
    SH3_10; SH3 domain
    pfam18373
    Location:1189 → 1266
    Spectrin_like; Spectrin like domain
    cd21239
    Location:363 → 466
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:201 → 358
    CH_SF; calponin homology (CH) domain superfamily
    cl02488
    Location:1406 → 1570
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  16. XM_038683814.1 → XP_038539742.1  dystonin isoform X6

    UniProtKB/TrEMBL
    A0A8C0SRD4
    Conserved Domains (13) summary
    smart00243
    Location:7490 → 7568
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    COG0419
    Location:4992 → 5551
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3822 → 4635
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7415 → 7477
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6594 → 6808
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2034
    Plectin; Plectin repeat
    pfam17902
    Location:1097 → 1163
    SH3_10; SH3 domain
    pfam18373
    Location:1198 → 1275
    Spectrin_like; Spectrin like domain
    cd21239
    Location:372 → 475
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:210 → 367
    CH_SF; calponin homology (CH) domain superfamily
    cl02488
    Location:1415 → 1579
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  17. XM_038683824.1 → XP_038539752.1  dystonin isoform X16

    UniProtKB/TrEMBL
    A0A8C0SWK1
    Conserved Domains (12) summary
    smart00243
    Location:7270 → 7345
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    smart00250
    Location:1553 → 1584
    PLEC; Plectin repeat
    COG0419
    Location:4772 → 5331
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3602 → 4415
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7195 → 7257
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6374 → 6588
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1775 → 1814
    Plectin; Plectin repeat
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  18. XM_038683823.1 → XP_038539751.1  dystonin isoform X15

    UniProtKB/TrEMBL
    A0A8C0SWK1
    Conserved Domains (12) summary
    smart00243
    Location:7303 → 7378
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:642 → 733
    SPEC; Spectrin repeats
    smart00250
    Location:1586 → 1617
    PLEC; Plectin repeat
    COG0419
    Location:4805 → 5364
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3635 → 4448
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7228 → 7290
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6407 → 6621
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1808 → 1847
    Plectin; Plectin repeat
    pfam17902
    Location:910 → 976
    SH3_10; SH3 domain
    pfam18373
    Location:1011 → 1088
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 180
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:185 → 288
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  19. XM_038683833.1 → XP_038539761.1  dystonin isoform X24

    UniProtKB/TrEMBL
    A0A8I3NPP6
    Related
    ENSCAFP00845018634.1, ENSCAFT00845023749.1
    Conserved Domains (12) summary
    pfam05483
    Location:1178 → 1814
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    PHA03307
    Location:5226 → 5381
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:2698 → 3257
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5012 → 5074
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4191 → 4405
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1512 → 2341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02187
    Location:5089 → 5163
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  20. XM_038683832.1 → XP_038539760.1  dystonin isoform X23

    UniProtKB/TrEMBL
    A0A8I3NQ54
    Conserved Domains (11) summary
    pfam05483
    Location:1178 → 1814
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:5196 → 5268
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    COG0419
    Location:2698 → 3257
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5121 → 5183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4300 → 4514
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1512 → 2341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  21. XM_038683830.1 → XP_038539758.1  dystonin isoform X22

    UniProtKB/TrEMBL
    A0A8I3NQ54
    Related
    ENSCAFP00845018814.1, ENSCAFT00845023955.1
    Conserved Domains (11) summary
    pfam05483
    Location:1178 → 1814
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:5196 → 5274
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    COG0419
    Location:2698 → 3257
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5121 → 5183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4300 → 4514
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1512 → 2341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  22. XM_038683826.1 → XP_038539754.1  dystonin isoform X18

    UniProtKB/TrEMBL
    A0A8I3NP68
    Related
    ENSCAFP00845018590.1, ENSCAFT00845023681.1
    Conserved Domains (13) summary
    smart00243
    Location:7161 → 7236
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    smart00250
    Location:1553 → 1584
    PLEC; Plectin repeat
    PHA03307
    Location:7300 → 7455
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:4772 → 5331
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3602 → 4415
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7086 → 7148
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6265 → 6479
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1775 → 1814
    Plectin; Plectin repeat
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  23. XM_038683825.1 → XP_038539753.1  dystonin isoform X17

    UniProtKB/TrEMBL
    A0A8C0SXA5
    Conserved Domains (13) summary
    smart00243
    Location:7270 → 7345
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    smart00250
    Location:1553 → 1584
    PLEC; Plectin repeat
    PHA03307
    Location:7409 → 7564
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:4772 → 5331
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3602 → 4415
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7195 → 7257
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6374 → 6588
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1775 → 1814
    Plectin; Plectin repeat
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  24. XM_038683820.1 → XP_038539748.1  dystonin isoform X12

    UniProtKB/TrEMBL
    A0A8C0KRH9
    Conserved Domains (12) summary
    smart00243
    Location:7385 → 7460
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:724 → 815
    SPEC; Spectrin repeats
    smart00250
    Location:1668 → 1699
    PLEC; Plectin repeat
    COG0419
    Location:4887 → 5446
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3717 → 4530
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7310 → 7372
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6489 → 6703
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1890 → 1929
    Plectin; Plectin repeat
    pfam17902
    Location:992 → 1058
    SH3_10; SH3 domain
    pfam18373
    Location:1093 → 1170
    Spectrin_like; Spectrin like domain
    cd21239
    Location:267 → 370
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl02488
    Location:1310 → 1474
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  25. XM_038683827.1 → XP_038539755.1  dystonin isoform X19

    UniProtKB/TrEMBL
    A0A8C0KPE4
    Conserved Domains (10) summary
    smart00243
    Location:6944 → 7019
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:283 → 374
    SPEC; Spectrin repeats
    smart00250
    Location:1227 → 1258
    PLEC; Plectin repeat
    COG0419
    Location:4446 → 5005
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3276 → 4089
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:6869 → 6931
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6048 → 6262
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1449 → 1488
    Plectin; Plectin repeat
    pfam17902
    Location:551 → 617
    SH3_10; SH3 domain
    pfam18373
    Location:652 → 729
    Spectrin_like; Spectrin like domain

  26. XM_038683834.1 → XP_038539762.1  dystonin isoform X25

    UniProtKB/TrEMBL
    A0A8I3NSC2
    Related
    ENSCAFP00845018865.1, ENSCAFT00845024019.1
    Conserved Domains (9) summary
    pfam05483
    Location:852 → 1488
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:4870 → 4948
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:283 → 374
    SPEC; Spectrin repeats
    COG0419
    Location:2372 → 2931
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:4795 → 4857
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:3974 → 4188
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1186 → 2015
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:551 → 617
    SH3_10; SH3 domain
    pfam18373
    Location:652 → 729
    Spectrin_like; Spectrin like domain

  27. XM_038683835.1 → XP_038539763.1  dystonin isoform X26

    UniProtKB/TrEMBL
    A0A8I3NGF3
    Related
    ENSCAFP00845018970.1, ENSCAFT00845024152.1
    Conserved Domains (8) summary
    smart00150
    Location:283 → 374
    SPEC; Spectrin repeats
    smart00250
    Location:2517 → 2554
    PLEC; Plectin repeat
    COG0419
    Location:746 → 1317
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:1105 → 1768
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:376 → 554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:2480 → 2519
    Plectin; Plectin repeat
    pfam17902
    Location:551 → 617
    SH3_10; SH3 domain
    pfam18373
    Location:652 → 729
    Spectrin_like; Spectrin like domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    23705703..24191186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038492118.1 → XP_038348046.1  dystonin isoform X27

  2. XM_038492104.1 → XP_038348032.1  dystonin isoform X13

  3. XM_038492098.1 → XP_038348026.1  dystonin isoform X7

  4. XM_038492094.1 → XP_038348022.1  dystonin isoform X3

  5. XM_038492101.1 → XP_038348029.1  dystonin isoform X10

  6. XM_038492092.1 → XP_038348020.1  dystonin isoform X1

  7. XM_038492102.1 → XP_038348030.1  dystonin isoform X11

  8. XM_038492111.1 → XP_038348039.1  dystonin isoform X20

    Conserved Domains (11) summary
    pfam05483
    Location:1365 → 2001
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:5383 → 5461
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:796 → 887
    SPEC; Spectrin repeats
    COG0419
    Location:2885 → 3444
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5308 → 5370
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4487 → 4701
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1699 → 2528
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:1064 → 1130
    SH3_10; SH3 domain
    pfam18373
    Location:1165 → 1242
    Spectrin_like; Spectrin like domain
    cd21236
    Location:210 → 334
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:339 → 442
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  9. XM_038492099.1 → XP_038348027.1  dystonin isoform X8

  10. XM_038492096.1 → XP_038348024.1  dystonin isoform X5

  11. XM_038492093.1 → XP_038348021.1  dystonin isoform X2

  12. XM_038492105.1 → XP_038348033.1  dystonin isoform X14

  13. XM_038492112.1 → XP_038348040.1  dystonin isoform X21

    Conserved Domains (11) summary
    pfam05483
    Location:1356 → 1992
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:5374 → 5452
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:787 → 878
    SPEC; Spectrin repeats
    COG0419
    Location:2876 → 3435
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5299 → 5361
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4478 → 4692
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1690 → 2519
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:1055 → 1121
    SH3_10; SH3 domain
    pfam18373
    Location:1156 → 1233
    Spectrin_like; Spectrin like domain
    cd21236
    Location:201 → 325
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:330 → 433
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  14. XM_038492100.1 → XP_038348028.1  dystonin isoform X9

  15. XM_038492095.1 → XP_038348023.1  dystonin isoform X4

  16. XM_038492097.1 → XP_038348025.1  dystonin isoform X6

  17. XM_038492107.1 → XP_038348035.1  dystonin isoform X16

  18. XM_038492106.1 → XP_038348034.1  dystonin isoform X15

  19. XM_038492115.1 → XP_038348043.1  dystonin isoform X24

    Conserved Domains (12) summary
    pfam05483
    Location:1178 → 1814
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    PHA03307
    Location:5226 → 5381
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:2698 → 3257
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5012 → 5074
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4191 → 4405
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1512 → 2341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02187
    Location:5089 → 5163
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  20. XM_038492114.1 → XP_038348042.1  dystonin isoform X23

    Conserved Domains (11) summary
    pfam05483
    Location:1178 → 1814
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:5196 → 5268
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    COG0419
    Location:2698 → 3257
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5121 → 5183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4300 → 4514
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1512 → 2341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  21. XM_038492113.1 → XP_038348041.1  dystonin isoform X22

    Conserved Domains (11) summary
    pfam05483
    Location:1178 → 1814
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:5196 → 5274
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    COG0419
    Location:2698 → 3257
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5121 → 5183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4300 → 4514
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1512 → 2341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  22. XM_038492109.1 → XP_038348037.1  dystonin isoform X18

  23. XM_038492108.1 → XP_038348036.1  dystonin isoform X17

  24. XM_038492103.1 → XP_038348031.1  dystonin isoform X12

  25. XM_038492110.1 → XP_038348038.1  dystonin isoform X19

  26. XM_038492116.1 → XP_038348044.1  dystonin isoform X25

    Conserved Domains (9) summary
    pfam05483
    Location:852 → 1488
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:4870 → 4948
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:283 → 374
    SPEC; Spectrin repeats
    COG0419
    Location:2372 → 2931
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:4795 → 4857
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:3974 → 4188
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1186 → 2015
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:551 → 617
    SH3_10; SH3 domain
    pfam18373
    Location:652 → 729
    Spectrin_like; Spectrin like domain

  27. XM_038492117.1 → XP_038348045.1  dystonin isoform X26

    Conserved Domains (8) summary
    smart00150
    Location:283 → 374
    SPEC; Spectrin repeats
    smart00250
    Location:2517 → 2554
    PLEC; Plectin repeat
    COG0419
    Location:746 → 1317
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:1105 → 1768
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:376 → 554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:2480 → 2519
    Plectin; Plectin repeat
    pfam17902
    Location:551 → 617
    SH3_10; SH3 domain
    pfam18373
    Location:652 → 729
    Spectrin_like; Spectrin like domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    23812683..24292223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038618267.1 → XP_038474195.1  dystonin isoform X27

  2. XM_038618253.1 → XP_038474181.1  dystonin isoform X13

  3. XM_038618246.1 → XP_038474174.1  dystonin isoform X7

  4. XM_038618242.1 → XP_038474170.1  dystonin isoform X3

  5. XM_038618250.1 → XP_038474178.1  dystonin isoform X10

  6. XM_038618240.1 → XP_038474168.1  dystonin isoform X1

  7. XM_038618251.1 → XP_038474179.1  dystonin isoform X11

  8. XM_038618260.1 → XP_038474188.1  dystonin isoform X20

  9. XM_038618247.1 → XP_038474175.1  dystonin isoform X8

  10. XM_038618244.1 → XP_038474172.1  dystonin isoform X5

  11. XM_038618241.1 → XP_038474169.1  dystonin isoform X2

  12. XM_038618254.1 → XP_038474182.1  dystonin isoform X14

  13. XM_038618261.1 → XP_038474189.1  dystonin isoform X21

  14. XM_038618249.1 → XP_038474177.1  dystonin isoform X9

  15. XM_038618243.1 → XP_038474171.1  dystonin isoform X4

  16. XM_038618245.1 → XP_038474173.1  dystonin isoform X6

  17. XM_038618256.1 → XP_038474184.1  dystonin isoform X16

  18. XM_038618255.1 → XP_038474183.1  dystonin isoform X15

  19. XM_038618264.1 → XP_038474192.1  dystonin isoform X24

  20. XM_038618263.1 → XP_038474191.1  dystonin isoform X23

  21. XM_038618262.1 → XP_038474190.1  dystonin isoform X22

  22. XM_038618258.1 → XP_038474186.1  dystonin isoform X18

  23. XM_038618257.1 → XP_038474185.1  dystonin isoform X17

  24. XM_038618252.1 → XP_038474180.1  dystonin isoform X12

  25. XM_038618259.1 → XP_038474187.1  dystonin isoform X19

  26. XM_038618265.1 → XP_038474193.1  dystonin isoform X25

  27. XM_038618266.1 → XP_038474194.1  dystonin isoform X26

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    23943092..24423680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038554403.1 → XP_038410331.1  dystonin isoform X27

    UniProtKB/TrEMBL
    A0A8C0R223

  2. XM_038554389.1 → XP_038410317.1  dystonin isoform X13

    UniProtKB/TrEMBL
    A0A8P0NZC6

  3. XM_038554383.1 → XP_038410311.1  dystonin isoform X7

    UniProtKB/TrEMBL
    A0A8C0N683

  4. XM_038554378.1 → XP_038410306.1  dystonin isoform X3

    UniProtKB/TrEMBL
    A0A8C0SPZ3

  5. XM_038554386.1 → XP_038410314.1  dystonin isoform X10

    UniProtKB/TrEMBL
    A0A8C0SPZ3

  6. XM_038554376.1 → XP_038410304.1  dystonin isoform X1

    UniProtKB/TrEMBL
    A0A8C0SPZ3

  7. XM_038554387.1 → XP_038410315.1  dystonin isoform X11

    UniProtKB/TrEMBL
    A0A8C0SQB1

  8. XM_038554396.1 → XP_038410324.1  dystonin isoform X20

    UniProtKB/TrEMBL
    A0A8C0KT90

  9. XM_038554384.1 → XP_038410312.1  dystonin isoform X8

    UniProtKB/TrEMBL
    A0A8C0SQB1

  10. XM_038554381.1 → XP_038410309.1  dystonin isoform X5

    UniProtKB/TrEMBL
    A0A8C0SPZ3

  11. XM_038554377.1 → XP_038410305.1  dystonin isoform X2

    UniProtKB/TrEMBL
    A0A8C0SPZ3

  12. XM_038554390.1 → XP_038410318.1  dystonin isoform X14

    UniProtKB/TrEMBL
    A0A8P0NZC6

  13. XM_038554397.1 → XP_038410325.1  dystonin isoform X21

    UniProtKB/TrEMBL
    A0A8C0KT90

  14. XM_038554385.1 → XP_038410313.1  dystonin isoform X9

    UniProtKB/TrEMBL
    A0A8C0N683

  15. XM_038554380.1 → XP_038410308.1  dystonin isoform X4

    UniProtKB/TrEMBL
    A0A8C0SPZ3

  16. XM_038554382.1 → XP_038410310.1  dystonin isoform X6

    UniProtKB/TrEMBL
    A0A8C0N683

  17. XM_038554392.1 → XP_038410320.1  dystonin isoform X16

    UniProtKB/TrEMBL
    A0A8C0SWK1

  18. XM_038554391.1 → XP_038410319.1  dystonin isoform X15

    UniProtKB/TrEMBL
    A0A8C0SWK1

  19. XM_038554400.1 → XP_038410328.1  dystonin isoform X24

    UniProtKB/TrEMBL
    A0A8I3NPP6

  20. XM_038554399.1 → XP_038410327.1  dystonin isoform X23

    UniProtKB/TrEMBL
    A0A8I3NQ54

  21. XM_038554398.1 → XP_038410326.1  dystonin isoform X22

    UniProtKB/TrEMBL
    A0A8I3NQ54

  22. XM_038554394.1 → XP_038410322.1  dystonin isoform X18

    UniProtKB/TrEMBL
    A0A8C0R1R4

  23. XM_038554393.1 → XP_038410321.1  dystonin isoform X17

    UniProtKB/TrEMBL
    A0A8C0SXA5

  24. XM_038554388.1 → XP_038410316.1  dystonin isoform X12

    UniProtKB/TrEMBL
    A0A8C0KRH9

  25. XM_038554395.1 → XP_038410323.1  dystonin isoform X19

    UniProtKB/TrEMBL
    A0A8C0KPE4

  26. XM_038554401.1 → XP_038410329.1  dystonin isoform X25

    UniProtKB/TrEMBL
    A0A8I3NSC2

  27. XM_038554402.1 → XP_038410330.1  dystonin isoform X26

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    23605476..24084492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014118090.3 → XP_013973565.1  dystonin isoform X27

    UniProtKB/TrEMBL
    A0A8C0R223
    Conserved Domains (9) summary
    smart00243
    Location:7457 → 7529
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:796 → 887
    SPEC; Spectrin repeats
    smart00250
    Location:1740 → 1771
    PLEC; Plectin repeat
    cd00014
    Location:223 → 325
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7382 → 7444
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6561 → 6775
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1962 → 2002
    Plectin; Plectin repeat
    pfam13499
    Location:7383 → 7443
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5152 → 5349
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  2. XM_014118081.3 → XP_013973556.1  dystonin isoform X13

    UniProtKB/TrEMBL
    A0A8P0NZC6
    Conserved Domains (9) summary
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    cd00014
    Location:372 → 475
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7306 → 7368
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6485 → 6699
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2035
    Plectin; Plectin repeat
    pfam02187
    Location:7384 → 7457
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7307 → 7367
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5185 → 5382
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  3. XM_014118076.3 → XP_013973551.1  dystonin isoform X7

    UniProtKB/TrEMBL
    A0A8C0N683
    Conserved Domains (9) summary
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    cd00014
    Location:372 → 475
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7415 → 7477
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6594 → 6808
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2035
    Plectin; Plectin repeat
    pfam02187
    Location:7493 → 7560
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7416 → 7476
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5185 → 5382
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  4. XM_014118072.3 → XP_013973547.1  dystonin isoform X3

    UniProtKB/TrEMBL
    A0A8C0SPZ3
    Conserved Domains (9) summary
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    cd00014
    Location:372 → 475
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7415 → 7477
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6594 → 6808
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2035
    Plectin; Plectin repeat
    pfam02187
    Location:7493 → 7560
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7416 → 7476
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5185 → 5382
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  5. XM_014118078.3 → XP_013973553.1  dystonin isoform X10

    UniProtKB/TrEMBL
    A0A8C0SPZ3
    Conserved Domains (9) summary
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    cd00014
    Location:372 → 475
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7415 → 7477
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6594 → 6808
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2035
    Plectin; Plectin repeat
    pfam02187
    Location:7493 → 7566
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7416 → 7476
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5185 → 5382
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  6. XM_014118071.3 → XP_013973546.1  dystonin isoform X1

    UniProtKB/TrEMBL
    A0A8C0SPZ3
    Conserved Domains (9) summary
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    cd00014
    Location:372 → 475
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7415 → 7477
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6594 → 6808
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2035
    Plectin; Plectin repeat
    pfam02187
    Location:7493 → 7566
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7416 → 7476
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5185 → 5382
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  7. XM_014118079.3 → XP_013973554.1  dystonin isoform X11

    UniProtKB/TrEMBL
    A0A8C0SQB1
    Conserved Domains (9) summary
    smart00150
    Location:787 → 878
    SPEC; Spectrin repeats
    smart00250
    Location:1731 → 1762
    PLEC; Plectin repeat
    cd00014
    Location:214 → 316
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7373 → 7435
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6552 → 6766
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1953 → 1993
    Plectin; Plectin repeat
    pfam02187
    Location:7451 → 7524
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7374 → 7434
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5143 → 5340
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  8. XM_014118088.3 → XP_013973563.1  dystonin isoform X20

    UniProtKB/TrEMBL
    A0A8C0KT90
    Conserved Domains (7) summary
    smart00150
    Location:796 → 887
    SPEC; Spectrin repeats
    cd00014
    Location:223 → 325
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:5308 → 5370
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4487 → 4701
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:5386 → 5459
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:5309 → 5369
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:3078 → 3275
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  9. XM_014118077.3 → XP_013973552.1  dystonin isoform X8

    UniProtKB/TrEMBL
    A0A8C0SQB1
    Conserved Domains (9) summary
    smart00150
    Location:796 → 887
    SPEC; Spectrin repeats
    smart00250
    Location:1740 → 1771
    PLEC; Plectin repeat
    cd00014
    Location:223 → 325
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7382 → 7444
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6561 → 6775
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1962 → 2002
    Plectin; Plectin repeat
    pfam02187
    Location:7460 → 7533
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7383 → 7443
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5152 → 5349
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  10. XM_014118074.3 → XP_013973549.1  dystonin isoform X5

    UniProtKB/TrEMBL
    A0A8C0SPZ3
    Conserved Domains (9) summary
    smart00150
    Location:808 → 899
    SPEC; Spectrin repeats
    smart00250
    Location:1752 → 1783
    PLEC; Plectin repeat
    cd00014
    Location:223 → 337
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7394 → 7456
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6573 → 6787
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1974 → 2014
    Plectin; Plectin repeat
    pfam02187
    Location:7472 → 7545
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7395 → 7455
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5164 → 5361
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  11. XM_005627500.3 → XP_005627557.1  dystonin isoform X2

    UniProtKB/TrEMBL
    A0A8C0SPZ3
    Conserved Domains (9) summary
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1769 → 1800
    PLEC; Plectin repeat
    cd00014
    Location:372 → 475
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7411 → 7473
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6590 → 6804
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1991 → 2031
    Plectin; Plectin repeat
    pfam02187
    Location:7489 → 7562
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7412 → 7472
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5181 → 5378
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  12. XM_038672859.1 → XP_038528787.1  dystonin isoform X14

    UniProtKB/TrEMBL
    A0A8P0NZC6
    Conserved Domains (14) summary
    smart00243
    Location:7381 → 7456
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    PHA03307
    Location:7520 → 7675
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:4992 → 5551
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3822 → 4635
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7306 → 7368
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6485 → 6699
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2034
    Plectin; Plectin repeat
    pfam17902
    Location:1097 → 1163
    SH3_10; SH3 domain
    pfam18373
    Location:1198 → 1275
    Spectrin_like; Spectrin like domain
    cd21239
    Location:372 → 475
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:210 → 367
    CH_SF; calponin homology (CH) domain superfamily
    cl02488
    Location:1415 → 1579
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  13. XM_005627505.2 → XP_005627562.1  dystonin isoform X21

    UniProtKB/TrEMBL
    A0A8C0KT90
    Conserved Domains (7) summary
    smart00150
    Location:787 → 878
    SPEC; Spectrin repeats
    cd00014
    Location:214 → 316
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:5299 → 5361
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4478 → 4692
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:5377 → 5450
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:5300 → 5360
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:3069 → 3266
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  14. XM_038672830.1 → XP_038528758.1  dystonin isoform X9

    UniProtKB/TrEMBL
    A0A8C0N683
    Conserved Domains (12) summary
    smart00243
    Location:7481 → 7559
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:820 → 911
    SPEC; Spectrin repeats
    smart00250
    Location:1764 → 1795
    PLEC; Plectin repeat
    COG0419
    Location:4983 → 5542
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3813 → 4626
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7406 → 7468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6585 → 6799
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1986 → 2025
    Plectin; Plectin repeat
    pfam17902
    Location:1088 → 1154
    SH3_10; SH3 domain
    pfam18373
    Location:1189 → 1266
    Spectrin_like; Spectrin like domain
    cd21239
    Location:363 → 466
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:201 → 358
    CH_SF; calponin homology (CH) domain superfamily

  15. XM_014118073.3 → XP_013973548.1  dystonin isoform X4

    UniProtKB/TrEMBL
    A0A8C0SPZ3
    Conserved Domains (9) summary
    smart00150
    Location:820 → 911
    SPEC; Spectrin repeats
    smart00250
    Location:1764 → 1795
    PLEC; Plectin repeat
    cd00014
    Location:363 → 466
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7406 → 7468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6585 → 6799
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1986 → 2026
    Plectin; Plectin repeat
    pfam02187
    Location:7484 → 7557
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7407 → 7467
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5176 → 5373
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  16. XM_014118075.3 → XP_013973550.1  dystonin isoform X6

    UniProtKB/TrEMBL
    A0A8C0N683
    Conserved Domains (9) summary
    smart00150
    Location:829 → 920
    SPEC; Spectrin repeats
    smart00250
    Location:1773 → 1804
    PLEC; Plectin repeat
    cd00014
    Location:372 → 475
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7415 → 7477
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6594 → 6808
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1995 → 2035
    Plectin; Plectin repeat
    pfam02187
    Location:7493 → 7566
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7416 → 7476
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5185 → 5382
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  17. XM_038672877.1 → XP_038528805.1  dystonin isoform X16

    UniProtKB/TrEMBL
    A0A8C0SWK1
    Conserved Domains (12) summary
    smart00243
    Location:7270 → 7345
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    smart00250
    Location:1553 → 1584
    PLEC; Plectin repeat
    COG0419
    Location:4772 → 5331
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3602 → 4415
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7195 → 7257
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6374 → 6588
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1775 → 1814
    Plectin; Plectin repeat
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  18. XM_014118083.3 → XP_013973558.2  dystonin isoform X15

    UniProtKB/TrEMBL
    A0A8C0SWK1
    Conserved Domains (12) summary
    smart00243
    Location:7303 → 7378
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:642 → 733
    SPEC; Spectrin repeats
    smart00250
    Location:1586 → 1617
    PLEC; Plectin repeat
    COG0419
    Location:4805 → 5364
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3635 → 4448
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7228 → 7290
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6407 → 6621
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1808 → 1847
    Plectin; Plectin repeat
    pfam17902
    Location:910 → 976
    SH3_10; SH3 domain
    pfam18373
    Location:1011 → 1088
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 180
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:185 → 288
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  19. XM_022426176.2 → XP_022281884.2  dystonin isoform X24

    UniProtKB/TrEMBL
    A0A8I3NPP6
    Conserved Domains (12) summary
    pfam05483
    Location:1178 → 1814
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    PHA03307
    Location:5226 → 5381
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:2698 → 3257
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5012 → 5074
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4191 → 4405
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1512 → 2341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02187
    Location:5089 → 5163
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  20. XM_038672915.1 → XP_038528843.1  dystonin isoform X23

    UniProtKB/TrEMBL
    A0A8I3NQ54
    Conserved Domains (11) summary
    pfam05483
    Location:1178 → 1814
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:5196 → 5268
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    COG0419
    Location:2698 → 3257
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5121 → 5183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4300 → 4514
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1512 → 2341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  21. XM_005627506.4 → XP_005627563.2  dystonin isoform X22

    UniProtKB/TrEMBL
    A0A8I3NQ54
    Conserved Domains (11) summary
    pfam05483
    Location:1178 → 1814
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:5196 → 5274
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    COG0419
    Location:2698 → 3257
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:5121 → 5183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4300 → 4514
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1512 → 2341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  22. XM_038672887.1 → XP_038528815.1  dystonin isoform X18

    UniProtKB/TrEMBL
    A0A8P0T0F5
    Conserved Domains (13) summary
    smart00243
    Location:7161 → 7236
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    smart00250
    Location:1553 → 1584
    PLEC; Plectin repeat
    PHA03307
    Location:7300 → 7455
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:4772 → 5331
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3602 → 4415
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7086 → 7148
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6265 → 6479
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1775 → 1814
    Plectin; Plectin repeat
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  23. XM_014118085.3 → XP_013973560.2  dystonin isoform X17

    UniProtKB/TrEMBL
    A0A8C0SXA5
    Conserved Domains (13) summary
    smart00243
    Location:7270 → 7345
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:609 → 700
    SPEC; Spectrin repeats
    smart00250
    Location:1553 → 1584
    PLEC; Plectin repeat
    PHA03307
    Location:7409 → 7564
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:4772 → 5331
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3602 → 4415
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:7195 → 7257
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6374 → 6588
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1775 → 1814
    Plectin; Plectin repeat
    pfam17902
    Location:877 → 943
    SH3_10; SH3 domain
    pfam18373
    Location:978 → 1055
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20 → 147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152 → 255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

  24. XM_014118080.3 → XP_013973555.1  dystonin isoform X12

    UniProtKB/TrEMBL
    A0A8C0KRH9
    Conserved Domains (9) summary
    smart00150
    Location:724 → 815
    SPEC; Spectrin repeats
    smart00250
    Location:1668 → 1699
    PLEC; Plectin repeat
    cd00014
    Location:267 → 370
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7310 → 7372
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6489 → 6703
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1890 → 1930
    Plectin; Plectin repeat
    pfam02187
    Location:7388 → 7461
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7311 → 7371
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:5080 → 5277
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  25. XM_022426174.2 → XP_022281882.1  dystonin isoform X19

    UniProtKB/TrEMBL
    A0A8C0KPE4
    Conserved Domains (8) summary
    smart00150
    Location:283 → 374
    SPEC; Spectrin repeats
    smart00250
    Location:1227 → 1258
    PLEC; Plectin repeat
    cd00051
    Location:6869 → 6931
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6048 → 6262
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1449 → 1489
    Plectin; Plectin repeat
    pfam02187
    Location:6946 → 7020
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl02488
    Location:869 → 1033
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl25732
    Location:3276 → 4089
    SMC_N; RecF/RecN/SMC N terminal domain

  26. XM_022426177.1 → XP_022281885.1  dystonin isoform X25

    UniProtKB/TrEMBL
    A0A8I3NSC2
    Conserved Domains (6) summary
    smart00243
    Location:4870 → 4948
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:283 → 374
    SPEC; Spectrin repeats
    cd00051
    Location:4795 → 4857
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:3974 → 4188
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl25588
    Location:628 → 1447
    NBD94; Nucleotide-Binding Domain 94 of RH
    cl25732
    Location:1186 → 2015
    SMC_N; RecF/RecN/SMC N terminal domain

  27. XM_038672923.1 → XP_038528851.1  dystonin isoform X26

    UniProtKB/TrEMBL
    A0A8I3NGF3
    Conserved Domains (8) summary
    smart00150
    Location:283 → 374
    SPEC; Spectrin repeats
    smart00250
    Location:2517 → 2554
    PLEC; Plectin repeat
    COG0419
    Location:746 → 1317
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:1105 → 1768
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:376 → 554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:2480 → 2519
    Plectin; Plectin repeat
    pfam17902
    Location:551 → 617
    SH3_10; SH3 domain
    pfam18373
    Location:652 → 729
    Spectrin_like; Spectrin like domain
Nucleotide Protein
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