glrx3 glutaredoxin 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: glrx3provided by ZNC
Official Full Name: glutaredoxin 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-22
See related: Ensembl:ENSDARG00000098785 AllianceGenome:ZFIN:ZDB-GENE-041010-22
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: txnl2; wu:fb38e09; zgc:103648
Summary: Predicted to enable iron-sulfur cluster binding activity; metal ion binding activity; and protein-disulfide reductase activity. Acts upstream of or within hemoglobin metabolic process and iron ion homeostasis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in brain; eye; heart; and intermediate cell mass of mesoderm. Orthologous to human GLRX3 (glutaredoxin 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (42369566..42396927, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (42214277..42241638, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that during embryonic development, depletion of Grx3 severely impairs the maturation of hemoglobin, the major iron-consuming process.
Title: Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation.

Submit: New GeneRIF Correction

General gene information

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Markers

fb38e09.x1 (e-PCR)
- UniSTS:190542

fb38e09.x1 (e-PCR)
- UniSTS:190543

AI444338 (e-PCR)
- UniSTS:206569

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hemoglobin metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hemoglobin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutaredoxin 3

Names: Grx3; thioredoxin-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005950.1 → NP_001005950.1 glutaredoxin 3

See identical proteins and their annotated locations for NP_001005950.1

Status: PROVISIONAL

Source sequence(s)

BC083453

UniProtKB/Swiss-Prot

Q5XJ54

UniProtKB/TrEMBL

B2GNX4

Related

ENSDARP00000133690.1, ENSDART00000160497.2

Conserved Domains (2) summary

cd02984
Location:9 → 104

TRX_PICOT; TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily; PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT contains an ...

cd03028
Location:128 → 217

GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...