P2RX7 purinergic receptor P2X 7 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: P2RX7provided by VGNC
Official Full Name: purinergic receptor P2X 7provided by VGNC
Primary source: VGNC:VGNC:44212
See related: Ensembl:ENSCAFG00845027103
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: P2X7
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 26

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	26	NC_051830.1 (8197891..8242043, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	26	NC_006608.4 (8105749..8148516, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	26	NC_049247.1 (8174038..8216804, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	26	NC_049286.1 (8159088..8201849, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	26	NC_049767.1 (8217646..8260409, complement)

Chromosome 26 - NC_051830.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the rs23314713 and rs23315462 missense variants of the P2RX7 gene are present in a large proportion of dogs, with the rs23314713 variant associated with a number of brachycephalic breeds
Title: Association of a P2RX7 gene missense variant with brachycephalic dog breeds.
We identified three candidate genes that were highly associated with glioma susceptibility: CAMKK2, P2RX7 and DENR. CAMKK2 showed reduced expression in both canine and human brain tumors, and a non-synonymous variant in P2RX7, previously demonstrated to have a 50% decrease in receptor function, was also associated with disease.
Title: Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus.
The canine P2RX7 gene encoded four missense polymorphisms.
Title: R270C polymorphism leads to loss of function of the canine P2X7 receptor.
The MDCK epithelial cell line expresses functional P2X7, as well as Toll-like receptor 4 and molecules associated with the NALP3 inflammasome.
Title: Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells.
The dog P2X7 receptor was 595 amino acids long and exhibited high homology (>70%) to the human and rodent orthologues although it contained an additional threonine at position 284 and an amino acid deletion at position 538
Title: Cloning and pharmacological characterization of the dog P2X7 receptor.
Report mechanism of action of species-selective P2X(7) receptor antagonists.
Title: Mechanism of action of species-selective P2X(7) receptor antagonists.
cation permeability increase induced by extracellular ATP in canine erythrocytes results from activation and opening of the P2X(7)
Title: Canine erythrocytes express the P2X7 receptor: greatly increased function compared with human erythrocytes.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to ATP	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: P2X purinoceptor 7

Names: P2X7 purinoceptor; purinergic receptor P2X, ligand-gated ion channel, 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113456.1 → NP_001106927.1 P2X purinoceptor 7

See identical proteins and their annotated locations for NP_001106927.1

Status: PROVISIONAL

Source sequence(s)

EU334661

UniProtKB/TrEMBL

A0A8C0PB41, A0A8P0NAU2, B0FLR1

Related

ENSCAFP00845037500.1, ENSCAFT00845047792.1

Conserved Domains (1) summary

pfam00864
Location:11 → 398

P2X_receptor; ATP P2X receptor

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051830.1 Reference ROS_Cfam_1.0

Range

8197891..8242043 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038436078.1 → XP_038292006.1 P2X purinoceptor 7 isoform X2

Conserved Domains (1) summary

pfam00864
Location:11 → 394

P2X_receptor; ATP P2X receptor
XM_038436077.1 → XP_038292005.1 P2X purinoceptor 7 isoform X1

UniProtKB/TrEMBL

A0A8P0NAU2

Related

ENSCAFP00845037548.1, ENSCAFT00845047862.1

Conserved Domains (1) summary

pfam00864
Location:11 → 394

P2X_receptor; ATP P2X receptor
XM_038436079.1 → XP_038292007.1 P2X purinoceptor 7 isoform X3

Conserved Domains (1) summary

pfam00864
Location:11 → 394

P2X_receptor; ATP P2X receptor