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MAPk-Ak2 MAP kinase activated protein-kinase-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44573, updated on 4-Apr-2024

Summary

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Official Symbol
MAPk-Ak2provided by FlyBase
Official Full Name
MAP kinase activated protein-kinase-2provided by FlyBase
Primary source
FLYBASE:FBgn0013987
Locus tag
Dmel_CG3086
See related
AllianceGenome:FB:FBgn0013987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2
Summary
Predicted to enable calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of cell size; regulation of JNK cascade; and response to salt stress. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head; organism; and ovary. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to several human genes including MAPKAPK3 (MAPK activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
5B8-5B8; 1-13 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5759908..5764203, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5653941..5658236, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45528 Neighboring gene lin-52 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila melanogaster homolog of the mammalian MAPK-activated protein kinase-2 (MAPKAPK-2) lacks a proline-rich N-terminus. Larochelle S, et al. Gene, 1995 Oct 3. PMID 7590268
  2. MK3 controls Polycomb target gene expression via negative feedback on ERK. Prickaerts P, et al. Epigenetics Chromatin, 2012 Aug 7. PMID 22870894, Free PMC Article
  3. The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU. Tian L, et al. J Biol Chem, 2014 Nov 14. PMID 25204651, Free PMC Article
  4. MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress. Seisenbacher G, et al. PLoS Genet, 2011 Aug. PMID 21829386, Free PMC Article
  5. Changes in Drosophila melanogaster midgut proteins in response to dietary Bowman-Birk inhibitor. Li HM, et al. Insect Mol Biol, 2007 Oct. PMID 17725801

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IscU is a new substrate of MK2 both in Drosophila cells and in human cells
    Title: The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell size IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
MAP kinase activated protein-kinase-2
Names
CG3086-PB
CG3086-PD
CG3086-PE
CG3086-PF
MAP kinase activated protein kinase-2
MAP kinase-activated protein kinase 2
MAPk-Ak2-PB
MAPk-Ak2-PD
MAPk-Ak2-PE
MAPk-Ak2-PF
NP_001188547.1
NP_001245536.1
NP_524769.1
NP_788861.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5759908..5764203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080030.5 → NP_524769.1  MAP kinase activated protein-kinase-2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524769.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49071, Q9W480
    UniProtKB/TrEMBL
    A4V402
    Related
    FBpp0070802
    Conserved Domains (2) summary
    smart00220
    Location:25 → 281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14089
    Location:18 → 280
    STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases

  2. NM_176688.3 → NP_788861.1  MAP kinase activated protein-kinase-2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788861.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49071, Q9W480
    UniProtKB/TrEMBL
    A4V402
    Related
    FBpp0070804
    Conserved Domains (2) summary
    smart00220
    Location:25 → 281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14089
    Location:18 → 280
    STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases

  3. NM_001201618.1 → NP_001188547.1  MAP kinase activated protein-kinase-2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188547.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49071, Q9W480
    UniProtKB/TrEMBL
    A4V402
    Conserved Domains (2) summary
    smart00220
    Location:25 → 281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14089
    Location:18 → 280
    STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases

  4. NM_001258607.2 → NP_001245536.1  MAP kinase activated protein-kinase-2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245536.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49071, Q9W480
    UniProtKB/TrEMBL
    A4V402
    Conserved Domains (2) summary
    smart00220
    Location:25 → 281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14089
    Location:18 → 280
    STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V402 A4V402
P49071.1 P49071
Q8T9D6 Q8T9D6

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