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ATPsynbeta ATP synthase, beta subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43829, updated on 4-Apr-2024

Summary

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Official Symbol
ATPsynbetaprovided by FlyBase
Official Full Name
ATP synthase, beta subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0010217
Locus tag
Dmel_CG11154
See related
AllianceGenome:FB:FBgn0010217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ATP; ATP syn-beta; ATP-B; ATP-syn-B; ATP-syn-beta; ATP-synbeta; ATP5B; ATP5beta; ATP5F1B; ATPase beta; ATPase-beta; ATPasebeta; ATPB; ATPsyn; ATPsyn b; ATPsyn-b; ATPsyn-beta; beta-ATPase; CG11154; Comp V beta; complex Vbeta; dATP5B; Dmel\CG11154
Summary
Predicted to enable ATP binding activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in mitochondrial ATP synthesis coupled proton transport. Located in mitochondrion. Is expressed in several structures, including adult circulatory system; adult head; embryonic/larval midgut; mesoderm; and spermatozoon. Orthologous to human ATP5F1B (ATP synthase F1 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
102F6-102F6; 4-0 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1031484..1034917)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1052110..1055543)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene Plexin A Neighboring gene antisense RNA:CR44031 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial inner membrane protein MPV17 Neighboring gene Calcium/calmodulin-dependent protein kinase II Neighboring gene Zyxin Neighboring gene apolipophorin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a proximal promoter region critical for the expression of the beta-F1-ATPase gene during Drosophila melanogaster development. Ugalde C, et al. Mitochondrion, 2001 Oct. PMID 16120280
  2. Intron distribution in ancient paralogs supports random insertion and not random loss. Cho G, et al. J Mol Evol, 1997 Jun. PMID 9169549
  3. The beta subunit of the Drosophila melanogaster ATP synthase: cDNA cloning, amino acid analysis and identification of the protein in adult flies. Peña P, et al. Biochem Biophys Res Commun, 1993 Sep 15. PMID 8373413
  4. Analysis of the mitochondrial ATP synthase beta-subunit gene in Drosophilidae: structure, transcriptional regulatory features and developmental pattern of expression in Drosophila melanogaster. Peña P, et al. Biochem J, 1995 Dec 15. PMID 8554535, Free PMC Article
  5. The expression of heat shock protein HSP60A reveals a dynamic mitochondrial pattern in Drosophila melanogaster embryos. Baena-López LA, et al. J Proteome Res, 2008 Jul. PMID 18549261

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the data from the present study revealed that ATP synthase serves important roles for male fertility during spermatogenesis by regulating germ cell maturation in Drosophila testes.
    Title: ATP synthase is required for male fertility and germ cell maturation in Drosophila testes.
  2. ATP synthase F1 subunits recruited to centromeres by CENP-A are required for male meiosis.
    Title: ATP synthase F(1) subunits recruited to centromeres by CENP-A are required for male meiosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial proton-transporting ATP synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial proton-transporting ATP synthase, catalytic core ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
part_of proton-transporting ATP synthase complex, catalytic core F(1) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase, beta subunit
Names
ATP synthase
ATP synthase beta
ATP synthase beta chain
ATP synthase beta subunit
ATP synthase beta-subunit
ATP synthase subunit beta
ATP synthase subunit beta, mitochondrial
ATP synthase subunits beta
ATP synthase-beta
ATPsynbeta-PA
ATPsynbeta-PC
ATPsynbeta-PD
CG11154-PA
CG11154-PC
CG11154-PD
F0/F1 ATP synthase beta
F1ATP synthase
H+-ATPase beta subunit
beta-F1-ATPase
complex V beta
mitochondrial ATPsynbeta

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    1031484..1034917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272152.1 → NP_001259081.1  ATP synthase, beta subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259081.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L0MQ04
    Conserved Domains (4) summary
    PRK09280
    Location:44 → 507
    PRK09280; F0F1 ATP synthase subunit beta; Validated
    cd01133
    Location:114 → 393
    F1-ATPase_beta; F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a ...
    pfam00306
    Location:401 → 508
    ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
    pfam02874
    Location:46 → 112
    ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain

  2. NM_001297790.1 → NP_001284719.1  ATP synthase, beta subunit, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284719.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q05825, Q9V494
    UniProtKB/TrEMBL
    X2JH42
    Conserved Domains (1) summary
    PRK09280
    Location:38 → 501
    PRK09280; F0F1 ATP synthase subunit beta; Validated

  3. NM_166808.3 → NP_726631.1  ATP synthase, beta subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726631.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q05825, Q9V494
    UniProtKB/TrEMBL
    X2JH42
    Related
    FBpp0088250
    Conserved Domains (1) summary
    PRK09280
    Location:38 → 501
    PRK09280; F0F1 ATP synthase subunit beta; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
L0MQ04 L0MQ04
Q05825.3 Q05825
Q6W4K9 Q6W4K9
Q6W4M9 Q6W4M9
X2JH42 X2JH42

Gene LinkOut

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