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E2f1 E2F transcription factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42550, updated on 11-Apr-2024

Summary

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Official Symbol
E2f1provided by FlyBase
Official Full Name
E2F transcription factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0011766
Locus tag
Dmel_CG6376
See related
AllianceGenome:FB:FBgn0011766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6376; dE2f; dE2F; de2f1; dE2f1; dE2F1; def21; DmE2F-1; Dmel\CG6376; Dp; drosE2F1; DRTF1/E2F; E(Sev-CycE)3A; E(var)3-93E; E(var)3-95E; E(var)93E; e2f; E2f; E2F; E2F-1; e2f1; E2F1; Evar(3)164; l(3)07172; l(3)j3B1; l(3)j3C2; l(3)rM729
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including DNA endoreduplication; positive regulation of nurse cell apoptotic process; and regulation of cellular macromolecule biosynthetic process. Located in nucleus. Part of Rb-E2F complex. Is expressed in several structures, including ectoderm; ectoderm anlage; extended germ band embryo; gut section; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to several human genes including E2F1 (E2F transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
93E9-93F1; 3-72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21620304..21660871, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17446026..17486593, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Insulin-like receptor Neighboring gene Insulin receptor-associated lncRNA Neighboring gene long non-coding RNA:CR44034 Neighboring gene mir-998 stem loop Neighboring gene mir-11 stem loop Neighboring gene antisense RNA:CR46055 Neighboring gene long non-coding RNA:CR46056 Neighboring gene long non-coding RNA:CR46057 Neighboring gene archease Neighboring gene Juvenile hormone binding protein 16 Neighboring gene DNA polymerase alpha subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional properties of a Drosophila homolog of the E2F1 gene. Ohtani K, et al. Mol Cell Biol, 1994 Mar. PMID 8114698, Free PMC Article
  2. Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells. Sekar A, et al. PLoS Genet, 2023 Jun. PMID 37363926, Free PMC Article
  3. Normal cell cycle progression requires negative regulation of E2F1 by Groucho during S phase and its relief at G2 phase. Bar-Cohen S, et al. Development, 2023 Jun 1. PMID 37260146, Free PMC Article
  4. The endocycle restores tissue tension in the Drosophila abdomen post wound repair. Losick VP, et al. Cell Rep, 2021 Oct 12. PMID 34644579, Free PMC Article
  5. Transposable Element Landscape in Drosophila Populations Selected for Longevity. Fabian DK, et al. Genome Biol Evol, 2021 Apr 5. PMID 33595657, Free PMC Article

See all (448) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced loss of heterozygosity in Drosophila melanogaster.
    Title: E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced loss of heterozygosity in Drosophila melanogaster.
  2. Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells.
    Title: Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells.
  3. Normal cell cycle progression requires negative regulation of E2F1 by Groucho during S phase and its relief at G2 phase.
    Title: Normal cell cycle progression requires negative regulation of E2F1 by Groucho during S phase and its relief at G2 phase.
  4. E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development.
    Title: E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development.
  5. Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.
    Title: Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.
  6. Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila.
    Title: Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila.
  7. Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
    Title: Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
  8. dE2F1b is a novel member of the E2F family, revealing a previously unappreciated complexity in the Drosophila RB/E2F network.
    Title: An alternatively spliced form affecting the Marked Box domain of Drosophila E2F1 is required for proper cell cycle regulation.
  9. specific alternate transcripts of activator E2F, dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor
    Title: Alternate transcripts of the Drosophila "activator" E2F are necessary for maintenance of cell cycle exit during development.
  10. These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.
    Title: E2F function in muscle growth is necessary and sufficient for viability in Drosophila.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA endoreduplication IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eggshell chorion gene amplification TAS
Traceable Author Statement
more info
 PubMed 
involved_in larval lymph gland hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nurse cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in ventral cord development HMP PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rb-E2F complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E2F transcription factor 1
Names
CG6376-PA
CG6376-PB
CG6376-PC
CG6376-PD
CG6376-PE
CG6376-PF
E2-promoter binding factor
E2F transcription factor
E2f1-PA
E2f1-PB
E2f1-PC
E2f1-PD
E2f1-PE
E2f1-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21620304..21660871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300526.1 → NP_001287455.1  E2F transcription factor 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287455.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77035, Q27368, Q5U0Z6
    UniProtKB/TrEMBL
    A0A0B4LHG1
    Conserved Domains (2) summary
    cd14660
    Location:327 → 428
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:256 → 318
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  2. NM_169962.3 → NP_732647.1  E2F transcription factor 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732647.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77035, Q27368, Q5U0Z6
    UniProtKB/TrEMBL
    A0A0B4LHG1
    Related
    FBpp0083517
    Conserved Domains (2) summary
    cd14660
    Location:327 → 428
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:256 → 318
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  3. NM_001300525.1 → NP_001287454.1  E2F transcription factor 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287454.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGM3
    Conserved Domains (3) summary
    cd14660
    Location:327 → 362
    E2F_DD; coiled coil [structural motif]
    pfam02319
    Location:256 → 318
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    cl22411
    Location:327 → 444
    E2F_DD; Dimerization domain of E2F transcription factors

  4. NM_169961.3 → NP_732646.1  E2F transcription factor 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732646.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77035, Q27368, Q5U0Z6
    UniProtKB/TrEMBL
    A0A0B4LHG1
    Related
    FBpp0083516
    Conserved Domains (2) summary
    cd14660
    Location:327 → 428
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:256 → 318
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  5. NM_079713.3 → NP_524437.2  E2F transcription factor 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524437.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77035, Q27368, Q5U0Z6
    UniProtKB/TrEMBL
    A0A0B4LHG1
    Related
    FBpp0083518
    Conserved Domains (2) summary
    cd14660
    Location:327 → 428
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:256 → 318
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  6. NM_001275880.2 → NP_001262809.1  E2F transcription factor 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262809.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGM3
    Conserved Domains (3) summary
    cd14660
    Location:327 → 362
    E2F_DD; coiled coil [structural motif]
    pfam02319
    Location:256 → 318
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    cl22411
    Location:327 → 444
    E2F_DD; Dimerization domain of E2F transcription factors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGM3 A0A0B4KGM3
A0A0B4LHG1 A0A0B4LHG1
Q27368.2 Q27368
Q8T0P0 Q8T0P0

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