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LPIN1 lipin 1 [ Gallus gallus (chicken) ]

Gene ID: 421945, updated on 3-Apr-2024

Summary

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Symbol
LPIN1provided by CGNC
Full Name
lipin 1provided by CGNC
Primary source
CGNC:12320
See related
Ensembl:ENSGALG00010002832
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
28
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (97090032..97161520)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (96908769..96980224)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110481 Neighboring gene E2F transcription factor 6 Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene uncharacterized LOC121110239 Neighboring gene uncharacterized LOC101751426 Neighboring gene uncharacterized LOC112532148

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Three indel variants in chicken LPIN1 exon 6/flanking region are associated with performance and carcass traits. Wang R, et al. Br Poult Sci, 2015. PMID 26523976
  2. A single-nucleotide polymorphism in the 3' untranslated region of the LPIN1 gene and association analysis with performance traits in chicken. Zhang SP, et al. Br Poult Sci, 2013 Jun. PMID 23796115
  3. Identification of the transcript isoforms and expression characteristics for chicken Lpin1. Wang XK, et al. Animal, 2012 Dec. PMID 23031312
  4. Distinct tissue expression profiles of chicken Lpin1-α/β isoforms and the effect of the variation on muscle fiber traits. Li S, et al. Gene, 2013 Feb 25. PMID 23266642

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chicken LPIN1 has an important effect on body, carcass and organ weight, serum lactate dehydrogenase traits, glucose and albumin level.
    Title: Three indel variants in chicken LPIN1 exon 6/flanking region are associated with performance and carcass traits.
  2. results suggested that chicken LPIN1 protein has a potential effect on muscle fibre development, but no effect on other studied traits
    Title: A single-nucleotide polymorphism in the 3' untranslated region of the LPIN1 gene and association analysis with performance traits in chicken.
  3. Total chicken Lpin1 gene mRNA expression level was elevated in hepatic and adipose tissues by 30% energy restriction, and presented a significantly inverse correlation with abdominal fat rate, serum high-density lipoprotein and total cholesterol.
    Title: Identification of the transcript isoforms and expression characteristics for chicken Lpin1.
  4. A multiple-nucleotide length polymorphism in the LPIN1 promoter shows significant association with muscle fiber traits, which suggests one novel role of Lpin1 on muscle fiber development.
    Title: Distinct tissue expression profiles of chicken Lpin1-α/β isoforms and the effect of the variation on muscle fiber traits.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fatty acid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidate phosphatase LPIN1
XP_004935828.2
XP_004935829.3
XP_004935830.2
XP_004935831.2
XP_015131575.2
XP_015131577.2
XP_015131579.2
XP_040522921.1
XP_040522922.1
XP_040522924.1
XP_040522925.2
XP_040522926.1
XP_040522927.1
XP_040522928.1
XP_040522929.1
XP_040522930.1
XP_040522931.1
XP_040522932.1
XP_040522933.1
XP_040553834.1
XP_040553835.1
XP_040553836.1
XP_040553837.1
XP_046770568.1
XP_046770570.1
XP_046770571.1
XP_046770572.1
XP_046770573.1
XP_046795185.1
XP_046795186.1
XP_046795187.1
XP_046795188.1
XP_046795189.1
XP_046795190.1
XP_419957.6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    97090032..97161520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015276089.4 → XP_015131575.2  phosphatidate phosphatase LPIN1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XBI6, A0A8V0XEH7
    Related
    ENSGALP00010004039.1, ENSGALT00010006577.1
    Conserved Domains (3) summary
    smart00775
    Location:787 → 943
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    PHA03307
    Location:307 → 552
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5083
    Location:50 → 159
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

  2. XM_004935771.5 → XP_004935828.2  phosphatidate phosphatase LPIN1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XBI6, A0A8V0XH84
    Related
    ENSGALP00010004040.1, ENSGALT00010006579.1
    Conserved Domains (3) summary
    smart00775
    Location:771 → 927
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    PHA03307
    Location:307 → 552
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5083
    Location:50 → 159
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

  3. XM_004935773.5 → XP_004935830.2  phosphatidate phosphatase LPIN1 isoform X6

    UniProtKB/TrEMBL
    H2CLW0
    Conserved Domains (3) summary
    smart00775
    Location:751 → 907
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:50 → 159
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    PRK00708
    Location:339 → 447
    PRK00708; twin-arginine translocase subunit TatB

  4. XM_015276093.4 → XP_015131579.2  phosphatidate phosphatase LPIN1 isoform X8

    UniProtKB/TrEMBL
    A0A8V0X7G4, H6SV45
    Related
    ENSGALP00010004042.1, ENSGALT00010006582.1
    Conserved Domains (3) summary
    smart00775
    Location:735 → 891
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:50 → 159
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    PRK00708
    Location:339 → 447
    PRK00708; twin-arginine translocase subunit TatB

  5. XM_040697900.2 → XP_040553834.1  phosphatidate phosphatase LPIN1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XBI6
    Conserved Domains (3) summary
    smart00775
    Location:768 → 924
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    PHA03307
    Location:288 → 533
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5083
    Location:31 → 140
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

  6. XM_419957.8 → XP_419957.6  phosphatidate phosphatase LPIN1 isoform X4

    Related
    ENSGALP00010004038.1, ENSGALT00010006574.1

  7. XM_046939232.1 → XP_046795188.1  phosphatidate phosphatase LPIN1 isoform X7

    Related
    ENSGALP00010004031.1, ENSGALT00010006558.1

  8. XM_015276091.4 → XP_015131577.2  phosphatidate phosphatase LPIN1 isoform X7

    UniProtKB/TrEMBL
    H2CLV9
    Conserved Domains (3) summary
    smart00775
    Location:738 → 894
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    PHA03307
    Location:258 → 503
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5083
    Location:1 → 110
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

  9. XM_004935774.5 → XP_004935831.2  phosphatidate phosphatase LPIN1 isoform X7

    UniProtKB/TrEMBL
    H2CLV9
    Conserved Domains (3) summary
    smart00775
    Location:738 → 894
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    PHA03307
    Location:258 → 503
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5083
    Location:1 → 110
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

  10. XM_040697903.2 → XP_040553837.1  phosphatidate phosphatase LPIN1 isoform X9

    UniProtKB/TrEMBL
    H2CLW0
    Related
    ENSGALP00010004037.1, ENSGALT00010006571.1
    Conserved Domains (3) summary
    smart00775
    Location:702 → 858
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:1 → 110
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    PRK00708
    Location:290 → 398
    PRK00708; twin-arginine translocase subunit TatB

  11. XM_046939234.1 → XP_046795190.1  phosphatidate phosphatase LPIN1 isoform X7

  12. XM_046939229.1 → XP_046795185.1  phosphatidate phosphatase LPIN1 isoform X5

  13. XM_046939231.1 → XP_046795187.1  phosphatidate phosphatase LPIN1 isoform X7

  14. XM_046939230.1 → XP_046795186.1  phosphatidate phosphatase LPIN1 isoform X5

  15. XM_040697902.2 → XP_040553836.1  phosphatidate phosphatase LPIN1 isoform X7

    UniProtKB/TrEMBL
    H2CLV9
    Conserved Domains (3) summary
    smart00775
    Location:738 → 894
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    PHA03307
    Location:258 → 503
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5083
    Location:1 → 110
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

  16. XM_046939233.1 → XP_046795189.1  phosphatidate phosphatase LPIN1 isoform X7

  17. XM_004935772.5 → XP_004935829.3  phosphatidate phosphatase LPIN1 isoform X5

    UniProtKB/TrEMBL
    A0A8V0XBI6
    Conserved Domains (3) summary
    smart00775
    Location:766 → 922
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    PHA03307
    Location:286 → 531
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5083
    Location:29 → 138
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

  18. XM_040697901.2 → XP_040553835.1  phosphatidate phosphatase LPIN1 isoform X7

    UniProtKB/TrEMBL
    H2CLV9
    Conserved Domains (3) summary
    smart00775
    Location:738 → 894
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    PHA03307
    Location:258 → 503
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5083
    Location:1 → 110
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    96908769..96980224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040666987.2 → XP_040522921.1  phosphatidate phosphatase LPIN1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XBI6
    Conserved Domains (4) summary
    PHA03307
    Location:307 → 552
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam04571
    Location:50 → 156
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:739 → 964
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:556 → 647
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  2. XM_040666988.2 → XP_040522922.1  phosphatidate phosphatase LPIN1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XBI6
    Conserved Domains (3) summary
    smart00775
    Location:771 → 927
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    PHA03307
    Location:307 → 552
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5083
    Location:50 → 159
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

  3. XM_040666993.2 → XP_040522927.1  phosphatidate phosphatase LPIN1 isoform X6

    UniProtKB/TrEMBL
    H2CLW0
    Conserved Domains (3) summary
    pfam04571
    Location:50 → 156
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:703 → 928
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:520 → 611
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  4. XM_040666998.2 → XP_040522932.1  phosphatidate phosphatase LPIN1 isoform X8

    UniProtKB/TrEMBL
    H6SV45
    Conserved Domains (3) summary
    smart00775
    Location:735 → 891
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:50 → 159
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    PRK00708
    Location:339 → 447
    PRK00708; twin-arginine translocase subunit TatB

  5. XM_040666990.2 → XP_040522924.1  phosphatidate phosphatase LPIN1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XBI6
    Conserved Domains (3) summary
    smart00775
    Location:768 → 924
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    PHA03307
    Location:288 → 533
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5083
    Location:31 → 140
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

  6. XM_040666991.2 → XP_040522925.2  phosphatidate phosphatase LPIN1 isoform X4

  7. XM_046914615.1 → XP_046770571.1  phosphatidate phosphatase LPIN1 isoform X7

  8. XM_040666995.2 → XP_040522929.1  phosphatidate phosphatase LPIN1 isoform X7

    UniProtKB/TrEMBL
    H2CLV9
    Conserved Domains (4) summary
    PHA03307
    Location:258 → 503
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:690 → 915
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:507 → 598
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  9. XM_040666994.2 → XP_040522928.1  phosphatidate phosphatase LPIN1 isoform X7

    UniProtKB/TrEMBL
    H2CLV9
    Conserved Domains (4) summary
    PHA03307
    Location:258 → 503
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:690 → 915
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:507 → 598
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  10. XM_040666999.2 → XP_040522933.1  phosphatidate phosphatase LPIN1 isoform X9

    UniProtKB/TrEMBL
    H2CLW0
    Conserved Domains (3) summary
    smart00775
    Location:702 → 858
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:1 → 110
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    PRK00708
    Location:290 → 398
    PRK00708; twin-arginine translocase subunit TatB

  11. XM_046914617.1 → XP_046770573.1  phosphatidate phosphatase LPIN1 isoform X7

  12. XM_040666992.2 → XP_040522926.1  phosphatidate phosphatase LPIN1 isoform X5

    UniProtKB/TrEMBL
    A0A8V0XBI6
    Conserved Domains (3) summary
    smart00775
    Location:766 → 922
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    PHA03307
    Location:286 → 531
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5083
    Location:29 → 138
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

  13. XM_046914614.1 → XP_046770570.1  phosphatidate phosphatase LPIN1 isoform X7

  14. XM_046914612.1 → XP_046770568.1  phosphatidate phosphatase LPIN1 isoform X5

  15. XM_040666997.2 → XP_040522931.1  phosphatidate phosphatase LPIN1 isoform X7

    UniProtKB/TrEMBL
    H2CLV9
    Conserved Domains (4) summary
    PHA03307
    Location:258 → 503
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:690 → 915
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:507 → 598
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  16. XM_046914616.1 → XP_046770572.1  phosphatidate phosphatase LPIN1 isoform X7

  17. XM_040666996.2 → XP_040522930.1  phosphatidate phosphatase LPIN1 isoform X7

    UniProtKB/TrEMBL
    H2CLV9
    Conserved Domains (4) summary
    PHA03307
    Location:258 → 503
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:690 → 915
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:507 → 598
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
Nucleotide Protein Strain
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