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GHR growth hormone receptor [ Gallus gallus (chicken) ]

Gene ID: 408184, updated on 3-Apr-2024

Summary

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Symbol
GHRprovided by CGNC
Full Name
growth hormone receptorprovided by CGNC
Primary source
CGNC:11022
See related
Ensembl:ENSGALG00010014614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
GHBP
Orthologs
human mouse all
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Genomic context

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See GHR in Genome Data Viewer
Location:
chromosome: Z
Exon count:
14
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (13962241..14094496)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (13962187..14094496)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene C5orf51 homolog Neighboring gene F-box protein 4 Neighboring gene coiled-coil domain containing 152 Neighboring gene uncharacterized LOC107049314 Neighboring gene selenoprotein P1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pattern of GHR mRNA expression and body growth in the S2 line of sex-linked dwarf chickens. Huang HY, et al. Genet Mol Res, 2016 Nov 3. PMID 27819736
  2. Expression and localization of growth hormone receptor in the oviduct of the laying hen (Gallus domesticus). Hrabia A, et al. Folia Biol (Krakow), 2013. PMID 24279179
  3. Expression profiles of somatotropic axis genes in lines of chickens divergently selected for 56-day body weight. Wu G, et al. Anim Biotechnol, 2011 Apr. PMID 21500111
  4. Growth hormone promotes axon growth in the developing nervous system. Baudet ML, et al. Endocrinology, 2009 Jun. PMID 19213842
  5. Growth hormone and its receptor in projection neurons of the chick visual system: retinofugal and tectobulbar tracts. Baudet ML, et al. Neuroscience, 2007 Aug 10. PMID 17618059

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the molecular mechanisms underlying growth hormone receptor (GHR) in Sex-linked dwarf chickens, was examined.
    Title: Pattern of GHR mRNA expression and body growth in the S2 line of sex-linked dwarf chickens.
  2. GHR mRNA was expressed in all examined oviductal segments with a significantly lower level in the infundibulum in comparison to other parts of the oviduct; specific GHR immunoreactivity was also detected in the wall of the oviduct.
    Title: Expression and localization of growth hormone receptor in the oviduct of the laying hen (Gallus domesticus).
  3. Between 3 and 6 wk of age, growth hormone receptor expression increased with age in adipose tissue.
    Title: Expression of genes for interleukins, neuropeptides, growth hormone receptor, and leptin receptor in adipose tissue from growing broiler chickens.
  4. There is a critical miRNA, let-7b, involved in the regulation of GHR.
    Title: Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens.
  5. Pectoralis major muscle GHR mRNA was greater in line of low weight than high weight selected chicken.
    Title: Expression profiles of somatotropic axis genes in lines of chickens divergently selected for 56-day body weight.
  6. Growth hormone (GH) receptor mRNA was also detected within cells of the E7 retinal ganglion cells (RGC) layer and GH receptor protein colocalized with GH in RGC axons.
    Title: Growth hormone promotes axon growth in the developing nervous system.
  7. The expression of GHR gene was more than 3-fold higher in dwarf chickens, compared with that of the normal.
    Title: [Expression profiling of GH, GHR, and IGF-1 genes in sex-linked dwarf chickens].
  8. results demonstrate presence of growth hormone and its receptors in the ovarian stroma with cortical follicles & in the wall of small and large follicles of the ovary during sexual maturation
    Title: Expression and localization of growth hormone and its receptors in the chicken ovary during sexual maturation.
  9. These results support the possibility that GH acts as a local growth factor during early embryonic development of the visual system.
    Title: Growth hormone and its receptor in projection neurons of the chick visual system: retinofugal and tectobulbar tracts.
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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of growth hormone receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
growth hormone receptor
Names
GH receptor
growth hormone binding protein
somatotropin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001293.2 → NP_001001293.2  growth hormone receptor isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000089
    UniProtKB/TrEMBL
    F1N9U3, M1SWX9
    Related
    ENSGALP00010020481.1, ENSGALT00010035089.1
    Conserved Domains (3) summary
    cd00063
    Location:120 → 220
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:289 → 587
    GHBP; Growth hormone receptor binding
    cl21522
    Location:29 → 105
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001397092.1 → NP_001384021.1  growth hormone receptor isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000089
    UniProtKB/TrEMBL
    Q45FF8
    Conserved Domains (2) summary
    cd00063
    Location:120 → 178
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:29 → 105
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    13962241..14094496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046905279.1 → XP_046761235.1  growth hormone receptor isoform X2

    UniProtKB/TrEMBL
    F1N9U3

  2. XM_046905281.1 → XP_046761237.1  growth hormone receptor isoform X2

    UniProtKB/TrEMBL
    F1N9U3

  3. XM_046905280.1 → XP_046761236.1  growth hormone receptor isoform X2

    UniProtKB/TrEMBL
    F1N9U3

  4. XM_046905278.1 → XP_046761234.1  growth hormone receptor isoform X1

    UniProtKB/TrEMBL
    A0A8V0YHW2
    Related
    ENSGALP00010020477.1, ENSGALT00010035078.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    13962187..14094496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046934919.1 → XP_046790875.1  growth hormone receptor isoform X2

    UniProtKB/TrEMBL
    F1N9U3

  2. XM_046934918.1 → XP_046790874.1  growth hormone receptor isoform X2

    UniProtKB/TrEMBL
    F1N9U3

  3. XM_046934917.1 → XP_046790873.1  growth hormone receptor isoform X2

    UniProtKB/TrEMBL
    F1N9U3

  4. XM_046934916.1 → XP_046790872.1  growth hormone receptor isoform X1

    UniProtKB/TrEMBL
    A0A8V0YHW2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02092.1 GenPept UniProtKB/Swiss-Prot:Q02092

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