sp7 Sp7 transcription factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sp7provided by ZNC
Official Full Name: Sp7 transcription factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040629-2
See related: Ensembl:ENSDARG00000019516 AllianceGenome:ZFIN:ZDB-GENE-040629-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: osx; osterix
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within animal organ morphogenesis; osteoblast differentiation; and regulation of osteoblast proliferation. Is expressed in several structures, including ectoderm; fin; head; optic primordium; and optic vesicle. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to human SP7 (Sp7 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (58622831..58674160)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (58628600..58679929)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cell transfection experiments demonstrated that Sp7 directly regulates the expression of dlx2b and bglap through Sp7-binding sites on the promoter regions of these two genes. Overall, this study provides new insight into the role of Sp7 in bone mineralization and tooth development.
Title: Sp7/osterix positively regulates dlx2b and bglap to affect tooth development and bone mineralization in zebrafish larvae.
In zebrafish lacking sp7, attachment bone is never present, independent of the stage of tooth development or fish age, yet replacement is not interrupted. There was abnormal orientation of teeth, and abnormal connection of pulp cavities of predecessor and replacement teeth, arrested dentinogenesis, non-polarization of odontoblasts and only a thin layer of dentin deposition.
Title: Zebrafish sp7 mutants show tooth cycling independent of attachment, eruption and poor differentiation of teeth.
Sp7 plays a critical role in limiting the level of signaling and the rate of bone growth
Title: Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures.
FGF and Wnt/beta-Catenin pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.
Title: Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation.
Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line.
Title: Zebrafish sp7:EGFP: a transgenic for studying otic vesicle formation, skeletogenesis, and bone regeneration.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial suture morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dentinogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor Sp7

Names: transcription factor osterix

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212863.2 → NP_998028.1 transcription factor Sp7

See identical proteins and their annotated locations for NP_998028.1

Status: PROVISIONAL

Source sequence(s)

CU694385, CU929258

UniProtKB/TrEMBL

Q6U1J4

Related

ENSDARP00000110025.2, ENSDART00000128793.3

Conserved Domains (4) summary

sd00017
Location:305 → 324

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:300 → 324

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:346 → 371

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:302 → 386

zf-C2H2_8; C2H2-type zinc ribbon