AMN amnion associated transmembrane protein [Canis lupus familiaris (dog)] - Gene

Summary

Gene symbol: AMN
Gene description: amnion associated transmembrane protein
See related: Ensembl:ENSCAFG00845017022
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	8	NC_051812.1 (71077067..71085111)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	8	NC_006590.4 (70312298..70320278)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	8	NC_049229.1 (71205503..71213499)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	8	NC_049268.1 (70740802..70748789)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	8	NC_049749.1 (70805229..70813173)

Chromosome 8 - NC_051812.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AMN interacts with the EGF domains of cubilin for membrane attachment and export from the endoplasmic reticulum, while extracellular cubilin does apical sorting of the complex in a carbohydrate-dependent manner
Title: Contribution of cubilin and amnionless to processing and membrane targeting of cubilin-amnionless complex.
Imerslund-Grasbeck syndromes due to an in-frame deletion of 33 nucleotides in exon 10 of AMN or a homozygous substitution in the AMN translation initiation codon abrogate AMN expression and block cubilin processing and targeting to the apical membrane.
Title: Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in protein localization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in endocytic vesicle	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein amnionless

Names: amnionless homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.