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fhl1a four and a half LIM domains 1a [ Danio rerio (zebrafish) ]

Gene ID: 399646, updated on 27-Mar-2024

Summary

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Official Symbol
fhl1aprovided by ZNC
Official Full Name
four and a half LIM domains 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040206-1
See related
Ensembl:ENSDARG00000071498 AllianceGenome:ZFIN:ZDB-GENE-040206-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fhl; fhla; zgc:92025
Summary
Predicted to enable transmembrane transporter binding activity. Acts upstream of or within heart development; locomotory behavior; and skeletal muscle satellite cell differentiation. Located in Z disc. Is expressed in several structures, including adaxial cell; blastomere; heart rudiment; musculature system; and pericardial region. Used to study myopathy. Human ortholog(s) of this gene implicated in Uruguay faciocardiomusculoskeletal syndrome; X-linked Emery-Dreifuss muscular dystrophy 6; reducing body myopathy 1A; and reducing body myopathy 1B. Orthologous to human FHL1 (four and a half LIM domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (31651516..31668498)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (31311190..31328184)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member A6a Neighboring gene membrane magnesium transporter 1 Neighboring gene MAP7 domain containing 3 Neighboring gene adhesion G protein-coupled receptor G4a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish cardiac enhancer trap lines: new tools for in vivo studies of cardiovascular development and disease. Poon KL, et al. Dev Dyn, 2010 Mar. PMID 20063419
  2. A zebrafish model for FHL1-opathy reveals loss-of-function effects of human FHL1 mutations. Keßler M, et al. Neuromuscul Disord, 2018 Jun. PMID 29735270
  3. Role of Zebrafish fhl1A in Satellite Cell and Skeletal Muscle Development. Chen F, et al. Curr Mol Med, 2017. PMID 29521230, Free PMC Article
  4. The LIM protein fhlA is essential for heart chamber development in zebrafish embryos. Xie H, et al. Curr Mol Med, 2013 Jul. PMID 23438903
  5. The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. Morgan MJ, et al. Biochem Biophys Res Commun, 1999 Feb 16. PMID 10049693

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac atrium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac chamber morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle satellite cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
four and a half LIM domains protein 1; four and a half LIM domains protein 1a
Names
four and a half LIM domains a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007287.1 → NP_001007288.1  four and a half LIM domains protein 1a

    See identical proteins and their annotated locations for NP_001007288.1

    Status: PROVISIONAL

    Source sequence(s)
    BC072725
    UniProtKB/TrEMBL
    B2GNQ9, Q6GQL7
    Related
    ENSDARP00000096545.3, ENSDART00000105767.4
    Conserved Domains (5) summary
    cd09344
    Location:56 → 110
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:234 → 297
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:118 → 175
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:179 → 231
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:21 → 49
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    31651516..31668498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291101.3 → XP_009289376.1  four and a half LIM domains protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A140LFQ9, A0A8M3AP71
    Related
    ENSDARP00000142083.1, ENSDART00000172835.2
    Conserved Domains (5) summary
    cd09344
    Location:40 → 94
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:218 → 281
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:102 → 159
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:163 → 215
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394915.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    224791..235783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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