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dscamb Down syndrome cell adhesion molecule b [ Danio rerio (zebrafish) ]

Gene ID: 386937, updated on 11-Apr-2024

Summary

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Official Symbol
dscambprovided by ZNC
Official Full Name
Down syndrome cell adhesion molecule bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031118-67
See related
Ensembl:ENSDARG00000028118 AllianceGenome:ZFIN:ZDB-GENE-031118-67
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fm10g02; wu:fm10g02; si:ch211-69g13.1
Summary
Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; dendrite self-avoidance; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within cell adhesion and nervous system development. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Predicted to be active in axon and plasma membrane. Is expressed in ciliary marginal zone; retina; retinal ganglion cell layer; retinal inner nuclear layer; and retinal outer nuclear layer. Orthologous to human DSCAM (DS cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See dscamb in Genome Data Viewer
Location:
chromosome: 15
Exon count:
33
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (6138423..6405153, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (6150470..6417460, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily, member 5b Neighboring gene Purkinje cell protein 4b Neighboring gene beta-secretase 2 Neighboring gene ATM serine/threonine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish expression reporters and mutants reveal that the IgSF cell adhesion molecule Dscamb is required for feeding and survival. Julien DP, et al. J Neurogenet, 2018 Dec. PMID 30204029, Free PMC Article
  2. Association Analysis of Variants of DSCAM and BACE2 With Hirschsprung Disease Susceptibility in Han Chinese and Functional Evaluation in Zebrafish. Lu YJ, et al. Front Cell Dev Biol, 2021. PMID 34136475, Free PMC Article
  3. Expression patterns of dscam and sdk gene paralogs in developing zebrafish retina. Galicia CA, et al. Mol Vis, 2018. PMID 30078982, Free PMC Article
  4. Transcripts within rod photoreceptors of the Zebrafish retina. Sun C, et al. BMC Genomics, 2018 Feb 8. PMID 29422031, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we have discovered a novel function for dscamb in feeding behavior.
    Title: Zebrafish expression reporters and mutants reveal that the IgSF cell adhesion molecule Dscamb is required for feeding and survival.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Down syndrome cell adhesion molecule homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    6138423..6405153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291475.3 → XP_009289750.1  Down syndrome cell adhesion molecule homolog isoform X2

    UniProtKB/TrEMBL
    A0A8M3AIA2
    Conserved Domains (7) summary
    cd00096
    Location:424 → 498
    Ig; Immunoglobulin domain
    cd05734
    Location:706 → 785
    Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
    smart00408
    Location:1302 → 1367
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:417 → 501
    IG_like; Immunoglobulin like
    cd00063
    Location:987 → 1084
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:595 → 685
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:803 → 890
    Ig; Immunoglobulin domain

  2. XM_009291474.3 → XP_009289749.1  Down syndrome cell adhesion molecule homolog isoform X1

    UniProtKB/TrEMBL
    A0A8M3B0R5, F1Q4W9
    Related
    ENSDARP00000088811.3, ENSDART00000098038.6
    Conserved Domains (7) summary
    cd00096
    Location:424 → 498
    Ig; Immunoglobulin domain
    cd05734
    Location:706 → 785
    Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
    smart00408
    Location:1302 → 1367
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:417 → 501
    IG_like; Immunoglobulin like
    cd00063
    Location:987 → 1084
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:595 → 685
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:803 → 890
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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