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ndnl2 necdin-like 2 [ Danio rerio (zebrafish) ]

Gene ID: 386658, updated on 27-Mar-2024

Summary

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Official Symbol
ndnl2provided by ZNC
Official Full Name
necdin-like 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-031107-3
See related
Ensembl:ENSDARG00000058212 AllianceGenome:ZFIN:ZDB-GENE-031107-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mage; zgc:101850
Summary
Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Bartter disease type 5; Prader-Willi syndrome; and Schaaf-Yang syndrome. Orthologous to several human genes including MAGEF1 (MAGE family member F1) and NSMCE3 (NSE3 homolog, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 23
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (12900416..12913131, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (13144339..13157054, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885711 Neighboring gene structural maintenance of chromosomes 1A, like Neighboring gene si:dkey-150i13.2 Neighboring gene paraneoplastic antigen Ma1 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A MAGE/NDN-like gene in zebrafish. Bischof JM, et al. Dev Dyn, 2003 Nov. PMID 14579385
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
necdin-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282089.1 → NP_001269018.1  necdin-like 2

    See identical proteins and their annotated locations for NP_001269018.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    EH545346, EH552618, EH568837
    UniProtKB/TrEMBL
    A0A8M1P0V1, Q7T0K5
    Related
    ENSDARP00000157669.1, ENSDART00000185095.1
    Conserved Domains (1) summary
    pfam01454
    Location:58 → 225
    MAGE; MAGE family

  2. NM_001282090.1 → NP_001269019.1  necdin-like 2

    See identical proteins and their annotated locations for NP_001269019.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY228339, EH545346, EH568837
    UniProtKB/TrEMBL
    A0A8M1P0V1, Q7T0K5
    Related
    ENSDARP00000075481.3, ENSDART00000081038.5
    Conserved Domains (1) summary
    pfam01454
    Location:58 → 225
    MAGE; MAGE family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    12900416..12913131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198812.1: Suppressed sequence

    Description
    NM_198812.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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