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Dpy19l4 dpy-19 like 4 [ Mus musculus (house mouse) ]

Gene ID: 381510, updated on 21-Apr-2024

Summary

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Official Symbol
Dpy19l4provided by MGI
Official Full Name
dpy-19 like 4provided by MGI
Primary source
MGI:MGI:2685869
See related
Ensembl:ENSMUSG00000045205 AllianceGenome:MGI:2685869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Narg3; Gm1023
Summary
Predicted to enable mannosyltransferase activity. Predicted to be involved in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in nuclear inner membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human DPY19L4 (dpy-19 like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 7.8), limb E14.5 (RPKM 4.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A1; 4 5.11 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11261315..11322153, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11261315..11322138, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A630034I12 gene Neighboring gene STARR-seq mESC enhancer starr_09593 Neighboring gene STARR-seq mESC enhancer starr_09594 Neighboring gene STARR-positive B cell enhancer ABC_E9234 Neighboring gene cyclin E2 Neighboring gene integrator complex subunit 8 Neighboring gene STARR-seq mESC enhancer starr_09596 Neighboring gene epithelial splicing regulatory protein 1 Neighboring gene ES cell cis-regulatory motif 9a Neighboring gene predicted gene, 35631

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. N-methyl-D-aspartate receptors regulate a group of transiently expressed genes in the developing brain. Sugiura N, et al. J Biol Chem, 2001 Apr 27. PMID 11297529
  2. Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex. Watanabe K, et al. Development, 2011 Nov. PMID 22028030, Free PMC Article
  3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable C-mannosyltransferase DPY19L4
Names
NMDA receptor-regulated gene 3
dpy-19-like protein 4
protein dpy-19 homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081201.2 → NP_001074670.1  probable C-mannosyltransferase DPY19L4

    See identical proteins and their annotated locations for NP_001074670.1

    Status: VALIDATED

    Source sequence(s)
    AL772170, AL840625, AL953845
    Consensus CDS
    CCDS38692.1
    UniProtKB/Swiss-Prot
    A2AJQ3, B2RW18, Q3T9A8
    Related
    ENSMUSP00000081954.6, ENSMUST00000084892.12
    Conserved Domains (1) summary
    pfam10034
    Location:60 → 713
    Dpy19; Q-cell neuroblast polarization

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    11261315..11322153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538041.5 → XP_006538104.1  probable C-mannosyltransferase DPY19L4 isoform X1

    Conserved Domains (1) summary
    pfam10034
    Location:1 → 652
    Dpy19; Q-cell neuroblast polarisation

  2. XM_006538042.5 → XP_006538105.1  probable C-mannosyltransferase DPY19L4 isoform X2

    UniProtKB/TrEMBL
    A2AJQ2
    Conserved Domains (1) summary
    pfam10034
    Location:1 → 456
    Dpy19; Q-cell neuroblast polarisation

RNA

  1. XR_004941929.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AJQ3.1 GenPept UniProtKB/Swiss-Prot:A2AJQ3

Gene LinkOut

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