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Nop60B Nucleolar protein at 60B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37873, updated on 11-Apr-2024

Summary

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Official Symbol
Nop60Bprovided by FlyBase
Official Full Name
Nucleolar protein at 60Bprovided by FlyBase
Primary source
FLYBASE:FBgn0259937
Locus tag
Dmel_CG3333
See related
AllianceGenome:FB:FBgn0259937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3333; DKC1; Dmel\CG3333; dUhg6; l(2)k05318; mfl; minifly; Nop60; nop60B; Nop60b; NOP60B; Nop60B/mfl; Nop60B/mnf; Uhg6
Summary
Predicted to enable pseudouridine synthase activity. Involved in RNA metabolic process; germ cell development; and wing disc development. Located in nucleolus. Is expressed in several structures, including adult head; ovary; and wing disc. Used to study X-linked dyskeratosis congenita and dyskeratosis congenita. Human ortholog(s) of this gene implicated in X-linked dyskeratosis congenita; aplastic anemia; and dyskeratosis congenita. Orthologous to human DKC1 (dyskerin pseudouridine synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
60C1-60C2; 2-106 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24174877..24186343)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20062400..20073866)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene mitochondrial ribosomal protein S17 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene over compensating males Neighboring gene cytosolic 5'-nucleotidase IIIB

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila dyskerin is required for somatic stem cell homeostasis. Vicidomini R, et al. Sci Rep, 2017 Mar 23. PMID 28337032, Free PMC Article
  2. Loss of Drosophila pseudouridine synthase triggers apoptosis-induced proliferation and promotes cell-nonautonomous EMT. Vicidomini R, et al. Cell Death Dis, 2015 Mar 26. PMID 25811802, Free PMC Article
  3. Mutations in Nop60B, the Drosophila homolog of human dyskeratosis congenita 1, affect the maintenance of the germ-line stem cell lineage during spermatogenesis. Kauffman T, et al. Dev Biol, 2003 Jan 15. PMID 12645924
  4. Structure and function of the nucleolus. Scheer U, et al. Curr Opin Cell Biol, 1999 Jun. PMID 10395554
  5. The Nop60B gene of Drosophila encodes an essential nucleolar protein that functions in yeast. Phillips B, et al. Mol Gen Genet, 1998 Oct. PMID 9829824

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study demonstrates that either ubiquitous or escargot-driven dyskerin depletion specifically abolishes the formation of the intestinal imaginal islands, the transient stem cell niche, without any apparent effect on the other midgut cell types.
    Title: Drosophila dyskerin is required for somatic stem cell homeostasis.
  2. Pseudouridine synthase (diskerin,Mfl)depletion also causes disruption of adherens cell junctions and ectopic induction of JNK (c-Jun N-terminal kinase) and Mmp1 (matrix metalloproteinase-1) activity, leading to a significant epithelial reorganization
    Title: Loss of Drosophila pseudouridine synthase triggers apoptosis-induced proliferation and promotes cell-nonautonomous EMT.
  3. results expand repertoire of coding/non-coding transcripts derived from the gene encoding Drosophila pseudouridine synthase It exhibits complex interlaced organization.
    Title: The coding/non-coding overlapping architecture of the gene encoding the Drosophila pseudouridine synthase.
  4. Mutations in Nop60B, the Drosophila homolog of human dyskeratosis congenita 1, affect the maintenance of the germ-line stem cell lineage during spermatogenesis.
    Title: Mutations in Nop60B, the Drosophila homolog of human dyskeratosis congenita 1, affect the maintenance of the germ-line stem cell lineage during spermatogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pseudouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in box H/ACA sno(s)RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in pseudouridine synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of box H/ACA snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of box H/ACA snoRNP complex TAS
Traceable Author Statement
more info
 PubMed 
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nucleolar protein at 60B
Names
CG3333-PA
CG3333-PB
CG3333-PC
CG3333-PF
CG3333-PG
Nop60B-PA
Nop60B-PB
Nop60B-PC
Nop60B-PF
Nop60B-PG
Uhg6
dUhg-like 6
minifly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24174877..24186343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169818.3 → NP_001163289.1  nucleolar protein at 60B, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163289.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8E745, O44081, Q0GLB4, Q0MVP1, Q8T408, Q9UAN8, Q9V3Z5
    UniProtKB/TrEMBL
    E1JGV6, H5V894
    Conserved Domains (4) summary
    cd02572
    Location:86 → 268
    PseudoU_synth_hDyskerin; Pseudouridine synthase, human dyskerin like
    TIGR00425
    Location:54 → 379
    CBF5; rRNA pseudouridine synthase, putative
    pfam01472
    Location:295 → 368
    PUA; PUA domain
    pfam08068
    Location:47 → 104
    DKCLD; DKCLD (NUC011) domain

  2. NM_001014547.4 → NP_001014547.1  nucleolar protein at 60B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014547.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8E745, O44081, Q0GLB4, Q0MVP1, Q8T408, Q9UAN8, Q9V3Z5
    UniProtKB/TrEMBL
    E1JGV6, H5V894
    Conserved Domains (4) summary
    cd02572
    Location:86 → 268
    PseudoU_synth_hDyskerin; Pseudouridine synthase, human dyskerin like
    TIGR00425
    Location:54 → 379
    CBF5; rRNA pseudouridine synthase, putative
    pfam01472
    Location:295 → 368
    PUA; PUA domain
    pfam08068
    Location:47 → 104
    DKCLD; DKCLD (NUC011) domain

  3. NM_001169815.3 → NP_001163286.1  nucleolar protein at 60B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163286.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8E745, O44081, Q0GLB4, Q0MVP1, Q8T408, Q9UAN8, Q9V3Z5
    UniProtKB/TrEMBL
    E1JGV6, H5V894
    Conserved Domains (4) summary
    cd02572
    Location:86 → 268
    PseudoU_synth_hDyskerin; Pseudouridine synthase, human dyskerin like
    TIGR00425
    Location:54 → 379
    CBF5; rRNA pseudouridine synthase, putative
    pfam01472
    Location:295 → 368
    PUA; PUA domain
    pfam08068
    Location:47 → 104
    DKCLD; DKCLD (NUC011) domain

  4. NM_001259561.2 → NP_001246490.1  nucleolar protein at 60B, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246490.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K8B2
    Conserved Domains (2) summary
    pfam08068
    Location:47 → 104
    DKCLD; DKCLD (NUC011) domain
    cl00130
    Location:86 → 214
    PseudoU_synth; Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)

  5. NM_080381.5 → NP_525120.1  nucleolar protein at 60B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525120.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8E745, O44081, Q0GLB4, Q0MVP1, Q8T408, Q9UAN8, Q9V3Z5
    UniProtKB/TrEMBL
    E1JGV6, H5V894
    Related
    FBpp0072166
    Conserved Domains (4) summary
    cd02572
    Location:86 → 268
    PseudoU_synth_hDyskerin; Pseudouridine synthase, human dyskerin like
    TIGR00425
    Location:54 → 379
    CBF5; rRNA pseudouridine synthase, putative
    pfam01472
    Location:295 → 368
    PUA; PUA domain
    pfam08068
    Location:47 → 104
    DKCLD; DKCLD (NUC011) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K8B2 A0A0B4K8B2
E1JGV6 E1JGV6
O44081.1 O44081

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