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Liprin-gamma [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37552, updated on 4-Apr-2024

Summary

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Official Symbol
Liprin-gammaprovided by FlyBase
Primary source
FLYBASE:FBgn0034720
Locus tag
Dmel_CG11206
See related
AllianceGenome:FB:FBgn0034720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11206; Dmel\CG11206; liprin; Liprin CG11206; liprin gamma; lipringamma
Summary
Enables protein homodimerization activity. Involved in axon target recognition and negative regulation of synaptic assembly at neuromuscular junction. Part of protein-containing complex. Is expressed in central nervous system; embryonic brain; eye disc; larval ventral nerve cord; and morphogenetic furrow. Orthologous to human KAZN (kazrin, periplakin interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
58D3-58D4; 2-99 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22333500..22373109, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18221005..18260614, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Gp150 Neighboring gene uncharacterized protein Neighboring gene Type III alcohol dehydrogenase Neighboring gene uncharacterized protein Neighboring gene polar granule component Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44759 Neighboring gene long non-coding RNA:CR45327 Neighboring gene Rtf1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Liprin-alpha has LAR-independent functions in R7 photoreceptor axon targeting. Hofmeyer K, et al. Proc Natl Acad Sci U S A, 2006 Aug 1. PMID 16864797, Free PMC Article
  2. Transient transcriptional silencing alters the cell cycle to promote germline stem cell differentiation in Drosophila. Flora P, et al. Dev Biol, 2018 Feb 1. PMID 29198563, Free PMC Article
  3. A comparison of midline and tracheal gene regulation during Drosophila development. Long SK, et al. PLoS One, 2014. PMID 24465586, Free PMC Article
  4. Common motifs shared by conserved enhancers of Drosophila midline glial genes. Fulkerson E, et al. J Exp Zool B Mol Dev Evol, 2011 Jan 15. PMID 21154525
  5. PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation. Arnés M, et al. Mol Biol Cell, 2020 Feb 15. PMID 31877058, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c22351469-22349755 mobile_element_type = transposon:jockey{}869

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon target recognition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Liprin-gamma
Names
CG11206-PA
CG11206-PB
CG11206-PC
CG11206-PD
CG11206-PE
Liprin-gamma-PA
Liprin-gamma-PB
Liprin-gamma-PC
Liprin-gamma-PD
Liprin-gamma-PE
liprin gamma
liprin-gamma

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22333500..22373109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137819.4 → NP_611663.2  Liprin-gamma, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611663.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W263
    Conserved Domains (5) summary
    cd09564
    Location:589 → 658
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:667 → 731
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:753 → 824
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    smart00454
    Location:676 → 731
    SAM; Sterile alpha motif
    pfam07106
    Location:212 → 308
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

  2. NM_001299787.1 → NP_001286716.1  Liprin-gamma, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286716.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LG34
    Conserved Domains (5) summary
    cd09564
    Location:648 → 717
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:726 → 790
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:812 → 883
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    smart00454
    Location:735 → 790
    SAM; Sterile alpha motif
    pfam07106
    Location:271 → 367
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

  3. NM_206200.3 → NP_995922.2  Liprin-gamma, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995922.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W263
    Conserved Domains (5) summary
    cd09564
    Location:589 → 658
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:667 → 731
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:753 → 824
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    smart00454
    Location:676 → 731
    SAM; Sterile alpha motif
    pfam07106
    Location:212 → 308
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

  4. NM_001103944.2 → NP_001097414.1  Liprin-gamma, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097414.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYM0
    Conserved Domains (5) summary
    cd09564
    Location:718 → 787
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:796 → 860
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:882 → 953
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    smart00454
    Location:805 → 860
    SAM; Sterile alpha motif
    pfam07106
    Location:341 → 437
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

  5. NM_001103945.2 → NP_001097415.1  Liprin-gamma, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097415.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYM1
    Conserved Domains (5) summary
    cd09564
    Location:589 → 658
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:667 → 731
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:753 → 824
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    smart00454
    Location:676 → 731
    SAM; Sterile alpha motif
    pfam07106
    Location:212 → 308
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LG34 A0A0B4LG34
A8DYM0 A8DYM0
A8DYM1 A8DYM1
Q9W263 Q9W263

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