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HDAC1 histone deacetylase 1 [ Gallus gallus (chicken) ]

Gene ID: 373961, updated on 5-Mar-2024

Summary

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Symbol
HDAC1provided by CGNC
Full Name
histone deacetylase 1provided by CGNC
Primary source
CGNC:2394
See related
Ensembl:ENSGALG00010017415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
HDAC1A
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
14
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 23 NC_052554.1 (5487288..5500608, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 23 NC_052595.1 (5250684..5264003, complement)

Chromosome 23 - NC_052554.1Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene MARCKS like 1 Neighboring gene LCK proto-oncogene, Src family tyrosine kinase Neighboring gene myotubularin related protein 9 like pseudogene Neighboring gene family with sequence similarity 167, member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and characterization of chicken erythrocyte histone deacetylase 1. Sun JM, et al. Biochemistry, 1999 May 4. PMID 10231548
  2. Distinct roles of HDAC1 and HDAC2 in transcription and recombination at the immunoglobulin loci in the chicken B cell line DT40. Kurosawa K, et al. J Biochem, 2010 Aug. PMID 20511365
  3. Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle. Slattery EL, et al. J Assoc Res Otolaryngol, 2009 Sep. PMID 19340485, Free PMC Article
  4. Chicken histone deacetylase-2 controls the amount of the IgM H-chain at the steps of both transcription of its gene and alternative processing of its pre-mRNA in the DT40 cell line. Takami Y, et al. J Biol Chem, 1999 Aug 20. PMID 10446166
  5. WD dipeptide motifs and LXXLL motif of chicken HIRA are essential for interactions with the p48 subunit of chromatin assembly factor-1 and histone deacetylase-2 in vitro and in vivo. Ahmad A, et al. Gene, 2004 Nov 10. PMID 15527972

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. transcription levels at IgL and IgH were decreased in HDAC1(-/-) cells, while other genes actively transcribed in B cells were slightly up-regulated compared to the levels in wild-type cells.
    Title: Distinct roles of HDAC1 and HDAC2 in transcription and recombination at the immunoglobulin loci in the chicken B cell line DT40.
  2. HDAC1 and HDAC2 are positive regulators of regenerative proliferation but they are not critical for avian hair cell differentiation.
    Title: Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 1
Names
HD1
protein deacetylase HDAC1
protein decrotonylase HDAC1
NP_989487.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204156.2 → NP_989487.1  histone deacetylase 1

    See identical proteins and their annotated locations for NP_989487.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000339
    UniProtKB/Swiss-Prot
    P56517
    UniProtKB/TrEMBL
    A0A8V0Z144
    Related
    ENSGALP00010024643.1, ENSGALT00010042088.1
    Conserved Domains (1) summary
    cd10010
    Location:4 → 374
    HDAC1; Histone deacetylase 1 (HDAC1)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052554.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5487288..5500608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052595.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5250684..5264003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56517.1 GenPept UniProtKB/Swiss-Prot:P56517

Gene LinkOut

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