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fyn.L FYN proto-oncogene, Src family tyrosine kinase L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 373609, updated on 11-Apr-2024

Summary

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Official Symbol
fyn.L
Official Full Name
FYN proto-oncogene, Src family tyrosine kinase L homeolog
Primary source
Xenbase:XB-GENE-6252893
Locus tag
XELAEV_18027176mg
See related
EnsemblRapid:ENSXLAG00005030036
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
fyn; slk; syn; c-fyn; fyn-a; fyn-b; cfyn-a
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Genomic context

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Location:
chromosome: 5L
Exon count:
16
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (80126846..80260245)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (77913558..78047140)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene tubulin epsilon 1 L homeolog Neighboring gene cellular communication network factor 6 L homeolog Neighboring gene E3 ubiquitin ligase TRAF3IP2 Neighboring gene REV3 like, DNA directed polymerase zeta catalytic subunit L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of Fyn tyrosine kinase causes abnormal development of primary sensory neurons in Xenopus laevis embryos. Saito R, et al. Dev Growth Differ, 2001 Jun. PMID 11422288
  2. Structure and expression of fyn genes in Xenopus laevis. Steele RE, et al. Oncogene, 1990 Mar. PMID 2179818
  3. Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance. Meriane M, et al. J Cell Biol, 2004 Nov 22. PMID 15557120, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Fyn
Names
p59-Fyn
proto-oncogene c-Fyn
proto-oncogene tyrosine-protein kinase Fyn
NP_001079077.1
XP_018117102.1
XP_018117103.1
XP_041417988.1
XP_041417989.1
XP_041417990.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085608.2 → NP_001079077.1  tyrosine-protein kinase Fyn

    See identical proteins and their annotated locations for NP_001079077.1

    Status: PROVISIONAL

    Source sequence(s)
    M27502
    UniProtKB/Swiss-Prot
    P13406, Q7ZYK3
    UniProtKB/TrEMBL
    Q32N74
    Related
    ENSXLAP00005089948.1, ENSXLAT00005091624.1
    Conserved Domains (4) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    pfam07714
    Location:271 → 520
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    80126846..80260245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018261614.2 → XP_018117103.1  tyrosine-protein kinase Fyn isoform X2

    UniProtKB/TrEMBL
    A0A8J0V922, Q32N74
    Related
    ENSXLAP00005090042.1, ENSXLAT00005091719.1

  2. XM_018261613.2 → XP_018117102.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A1L8G8Y4, A0A974CX51, Q32N74
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  3. XM_041562056.1 → XP_041417990.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A1L8G8Y4, A0A974CX51, Q32N74
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  4. XM_041562055.1 → XP_041417989.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A1L8G8Y4, A0A974CX51, Q32N74
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  5. XM_041562054.1 → XP_041417988.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A1L8G8Y4, A0A974CX51, Q32N74
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
Nucleotide Protein Strain
Heading Accession and Version

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